Regional and cellular gene expression changes in human Huntington's disease brain

Bioconductor: open software development for computational biology and bioinformatics.

2004 • 11,755 citations

Linear Models and Empirical Bayes Methods for Assessing Differential Expression in Microarray Experiments

2004 • 11,620 citations

PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes

2003 • 8,996 citations

A comparison of normalization methods for high density oligonucleotide array data based on variance and bias

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A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes

1993 • 7,941 citations

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2004 • 4,862 citations

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A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. The Huntington's Disease Collaborative Research Group.

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Neuropathological Classification of Huntingtonʼs Disease

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Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

2004 • 2,265 citations

Creating the gene ontology resource: design and implementation.

2001 • 831 citations

Suppression of polyglutamine-mediated neurodegeneration in Drosophila by the molecular chaperone HSP70

1999 • 830 citations

Decreased expression of striatal signaling genes in a mouse model of Huntington's disease

2000 • 722 citations

Huntingtin Expression Stimulates Endosomal–Lysosomal Activity, Endosome Tubulation, and Autophagy

2000 • 522 citations

The pattern of neurodegeneration in Huntington's disease: a comparative study of cannabinoid, dopamine, adenosine and GABAA receptor alterations in the human basal ganglia in Huntington's disease

2000 • 517 citations

Polyglutamine length-dependent interaction of Hsp40 and Hsp70 family chaperones with truncated N-terminal huntingtin: their role in suppression of aggregation and cellular toxicity

2000 • 433 citations

Nonapoptotic neurodegeneration in a transgenic mouse model of Huntington's disease

2000 • 433 citations

Dysregulation of gene expression in the R6/2 model of polyglutamine disease: parallel changes in muscle and brain

2002 • 365 citations

Effects of heat shock, heat shock protein 40 (HDJ-2), and proteasome inhibition on protein aggregation in cellular models of Huntington's disease

2000 • 360 citations

Effect of agonal and postmortem factors on gene expression profile: quality control in microarray analyses of postmortem human brain

2004 • 318 citations

A new polymerase chain reaction (PCR) assay for the trinucleotide repeat that is unstable and expanded on Huntington's disease chromosomes

1993 • 245 citations

Chronology of behavioral symptoms and neuropathological sequela in R6/2 Huntington's disease transgenic mice

2005 • 242 citations

Huntington's disease: the challenge for cell biologists

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Changes of NMDA Receptor Subunit (NR1, NR2B) and Glutamate Transporter (GLT1) mRNA Expression in Huntingtonʼs Disease—An In Situ Hybridization Study

1997 • 227 citations

Polyglutamine and transcription: gene expression changes shared by DRPLA and Huntington's disease mouse models reveal context-independent effects

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In Vitro Analysis of Huntingtin-Mediated Transcriptional Repression Reveals Multiple Transcription Factor Targets

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Dopamine D₁ and D₂ receptor gene expression in the striatum in Huntington's disease

1997 • 171 citations

Reduction in enkephalin and substance P messenger RNA in the striatum of early grade Huntington's disease: A detailed cellularin situ hybridization study

1996 • 149 citations

Altered transcriptional regulation in cells expressing the expanded polyglutamine androgen receptor

2002 • 145 citations

Increased huntingtin protein length reduces the number of polyglutamine-induced gene expression changes in mouse models of Huntington's disease

2002 • 142 citations

LOSS OF MATRIX CALCIUM-BINDING PROTEIN-CONTAINING NEURONS IN HUNTINGTON'S DISEASE

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The distribution of progenitor cells in the subependymal layer of the lateral ventricle in the normal and Huntington’s disease human brain

2005 • 128 citations

Transcriptional dysregulation in striatal projection- and interneurons in a mouse model of Huntington's disease: neuronal selectivity and potential neuroprotective role of HAP1

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Alterations in dopaminergic receptors in Huntington's disease

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Heterogeneous dopamine receptor changes in early and late Huntington's disease

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Huntington's Disease (3rd edn)

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Reduced expression of preproenkephalin in striatal neurons from huntington's disease patients

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A regression-based method to identify differentially expressed genes in microarray time course studies and its application in an inducible Huntington's disease transgenic model

2002 • 71 citations

Expression of Mutant Huntingtin Blocks Exocytosis in PC12 Cells by Depletion of Complexin II

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Genetically confirmed clinical Huntington's disease with no observable cell loss

2003 • 34 citations

An autopsy case with clinically and molecular genetically diagnosed Huntington's disease with only minimal non-specific neuropathological findings.

2000 • 26 citations

Microarrays and polyglutamine disorders: reports from the Hereditary Disease Array Group

2002 • 16 citations

The Hereditary Disease Array Group (HDAG) - Microarrays, Models and Mechanisms : A Collaboration Update

2001 • 3 citations