Identification of tyrosine kinase Trk as a nerve growth factor receptor.

The Nerve Growth Factor 35 Years Later

1987 • 3,107 citations

ERKs: A family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF

1991 • 1,901 citations

The trk proto-oncogene encodes a receptor for nerve growth factor

1991 • 1,396 citations

High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptor

1991 • 1,232 citations

Tyrosine phosphorylation and tyrosine kinase activity of the trk proto-oncogene product induced by NGF

1991 • 1,049 citations

Molecular cloning and expression of a receptor for human tumor necrosis factor

1990 • 973 citations

Expression and structure of the human NGF receptor

1986 • 956 citations

Gene transfer and molecular cloning of the rat nerve growth factor receptor

1987 • 946 citations

NPXY, a sequence often found in cytoplasmic tails, is required for coated pit-mediated internalization of the low density lipoprotein receptor.

1990 • 944 citations

Molecular cloning and expression of the human 55 kd tumor necrosis factor receptor

1990 • 918 citations

trkB encodes a functional receptor for brain-derived neurotrophic factor and neurotrophin-3 but not nerve growth factor

1991 • 830 citations

The neurotrophic factors brain-derived neurotrophic factor and neurotrophin-3 are ligands for the trkB tyrosine kinase receptor

1991 • 819 citations

trkB, a neural receptor protein-tyrosine kinase: evidence for a full-length and two truncated receptors.

1991 • 785 citations

Nerve growth factor receptors on human melanoma cells in culture.

1977 • 670 citations

trkB, a novel tyrosine protein kinase receptor expressed during mouse neural development.

1989 • 604 citations

Molecular and biochemical characterization of the human trk proto-oncogene.

1989 • 600 citations

A B-lymphocyte activation molecule related to the nerve growth factor receptor and induced by cytokines in carcinomas.

1989 • 527 citations

A monoclonal antibody modulates the interaction of nerve growth factor with PC12 cells.

1984 • 503 citations

Gene Transfer and Molecular Cloning of the Human NGF Receptor

1986 • 447 citations

Expression of the trk proto-oncogene is restricted to the sensory cranial and spinal ganglia of neural crest origin in mouse development.

1990 • 342 citations

K-252a: a specific inhibitor of the action of nerve growth factor on PC 12 cells

1988 • 320 citations

Characterization of nerve growth factor receptor in neural crest tumors using monoclonal antibodies.

1984 • 318 citations

Nerve growth factor receptors on PC12 cells: Evidence for two receptor classes with differing cytoskeletal association

1981 • 302 citations

Evidence that biological activity of NGF is mediated through a novel subclass of high affinity receptors

1991 • 296 citations

PC12 cell mutants that possess low- but not high-affinity nerve growth factor receptors neither respond to nor internalize nerve growth factor.

1986 • 282 citations

Expression of Functional Nerve Growth Factor Receptors After Gene Transfer

1989 • 235 citations

A dominant negative mutation suppresses the function of normal epidermal growth factor receptors by heterodimerization.

1991 • 227 citations

Nerve growth factor rapidly induces c-fos mRNA in PC12 rat pheochromocytoma cells.

1986 • 220 citations

Nerve growth factor induces protein-tyrosine phosphorylation.

1988 • 184 citations

Structure and developmental expression of the nerve growth factor receptor in the chicken central nervous system

1989 • 171 citations

Nerve growth factor stimulates phosphorylation of phospholipase C-gamma in PC12 cells

1991 • 168 citations

Characterization of the human melanoma nerve growth factor receptor.

1985 • 162 citations

A single Mr approximately 103,000 125I-beta-nerve growth factor-affinity-labeled species represents both the low and high affinity forms of the nerve growth factor receptor.

1986 • 159 citations

Molecular investigations on the high-affinity nerve growth factor receptor

1991 • 154 citations

A sequence motif in the transmembrane region of growth factor receptors with tyrosine kinase activity mediates dimerization

1990 • 146 citations

Induction by NGF of Meiotic Maturation of Xenopus Oocytes Expressing the trk Proto-Oncogene Product

1991 • 133 citations

Nerve growth factor receptors on cultured rat Schwann cells

1988 • 131 citations

trkB, a Neural Receptor Protein-Tyrosine Kinase: Evidence for a Full-Length and Two Truncated Receptors

1991 • 131 citations

Nerve growth factor stimulates the hydrolysis of glycosylphosphatidylinositol in PC-12 cells: a mechanism of protein kinase C regulation.

1989 • 126 citations

Molecular and Biochemical Characterization of the Human trk Proto-Oncogene

1989 • 124 citations

Structure and developmental expression of the chicken NGF receptor

1990 • 120 citations

Chimeric NGF-EGF Receptors Define Domains Responsible for Neuronal Differentiation

1991 • 116 citations

Purification of the receptor for nerve growth factor from A875 melanoma cells by affinity chromatography.

1983 • 104 citations

[3] Assaying binding of nerve growth factor to cell surface receptors

1985 • 102 citations

Affinity labeling and partial purification of nerve growth factor receptors from rat pheochromocytoma and human melanoma cells.

1983 • 99 citations

The internalization of nerve growth factor by high-affinity receptors on pheochromocytoma PC12 cells.

1987 • 98 citations

Deletion of cytoplasmic sequences of the nerve growth factor receptor leads to loss of high affinity ligand binding.

1990 • 94 citations

Nerve Growth Factor (NGF) Induces Neuronal Differentiation in Neuroblastoma Cells Transfected with the NGF Receptor cDNA

1990 • 72 citations

Introduction of nerve growth factor (NGF) receptors into a medulloblastoma cell line results in expression of high- and low-affinity NGF receptors but not NGF-mediated differentiation.

1990 • 71 citations

Nerve growth factor binding domain of the nerve growth factor receptor.

1991 • 59 citations

Purine analogs inhibit nerve growth factor-promoted neurite outgrowth by sympathetic and sensory neurons

1990 • 58 citations

Association of nerve growth factor receptors with the triton X-100 cytoskeleton of PC12 cells

1985 • 56 citations

Role of protein tyrosine phosphorylation in the NGF response

1989 • 52 citations

A comparison of binding properties and structure of NGF receptor on PC12 pheochromocytoma and A875 melanoma cells

1983 • 48 citations

Internalization of nerve growth factor by PC12 cells. A description of cellular pools.

1988 • 29 citations

Affinity labeling of a nerve growth factor receptor component on rat pheochromocytoma (PC12) cells

1982 • 27 citations

Relationship among types of nerve growth factor receptors on PC12 cells.

1990 • 26 citations

Induction of ornithine decarboxylase by nerve growth factor in PC12 cells: dissection by purine analogues.

1990 • 26 citations

Inhibition of PC-12 cell differentiation by the immediate early gene fra-1.

1990 • 24 citations

Nerve growth factor receptors are preaggregated and immobile on responsive cells

1991 • 19 citations

Gene transfer of truncated NGF receptor clones leads to cell surface expression in mouse fibroblasts

1989 • 12 citations