Possible involvement of pregnane X receptor–enhanced CYP24 expression in drug-induced osteomalacia

Vitamin D

1979 • 3,814 citations

The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions.

1998 • 1,535 citations

An Orphan Nuclear Receptor Activated by Pregnanes Defines a Novel Steroid Signaling Pathway

1998 • 1,497 citations

The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity

2001 • 1,271 citations

Vitamin D Receptor As an Intestinal Bile Acid Sensor

2002 • 1,100 citations

The Repressed Nuclear Receptor CAR Responds to Phenobarbital in Activating the Human CYP2B6 Gene

1999 • 658 citations

Accelerated bone mineral loss in HIV-infected patients receiving potent antiretroviral therapy

2000 • 542 citations

Identification of rifampin-inducible P450IIIA4 (CYP3A4) in human small bowel enterocytes.

1992 • 536 citations

CYP3A4 Induction by Drugs: Correlation between a Pregnane X Receptor Reporter Gene Assay and CYP3A4 Expression in Human Hepatocytes

2002 • 438 citations

De-orphanization of Cytochrome P450 2R1

2003 • 376 citations

Regulation of the human CYP2B6 gene by the nuclear pregnane X receptor.

2001 • 355 citations

Expression of CYP3A4, CYP2B6, andCYP2C9 Is Regulated by the Vitamin D Receptor Pathway in Primary Human Hepatocytes

2002 • 350 citations

The expression of CYP2B6, CYP2C9 and CYP3A4 genes: a tangle of networks of nuclear and steroid receptors

2003 • 331 citations

Transcriptional Control of Intestinal Cytochrome P-4503A by 1α,25-Dihydroxy Vitamin D₃

2001 • 321 citations

Deficient Mineralization of Intramembranous Bone in Vitamin D-24-Hydroxylase-Ablated Mice Is Due to Elevated 1,25-Dihydroxyvitamin D and Not to the Absence of 24,25-Dihydroxyvitamin D*

2000 • 321 citations

A competitive protein-binding assay for 25-hydroxy-cholecalciferol and 25-hydroxyergocalciferol in serum

1974 • 302 citations

Cloning of the human 1α,25-dihydroxyvitamin D-3 24-hydroxylase gene promoter and identification of two vitamin D-responsive elements

1995 • 281 citations

Regulation of CYP3A4 Expression in Human Hepatocytes by Pharmaceuticals and Natural Products

2003 • 248 citations

Identification of a vitamin D-responsive element in the 5'-flanking region of the rat 25-hydroxyvitamin D3 24-hydroxylase gene.

1994 • 231 citations

Vitamin D. Gene Regulation, Structure-Function Analysis and Clinical Application

1991 • 230 citations

Antiepileptic Drug–Induced Bone Loss in Young Male Patients Who Have Seizures

2002 • 205 citations

The Function of Vitamin D Receptor in Vitamin D Action

2000 • 199 citations

Effect of corticosteroids on the expression of cytochromes P450 and on cyclosporin A oxidase activity in primary cultures of human hepatocytes.

1992 • 197 citations

Peptide Mimetic HIV Protease Inhibitors Are Ligands for the Orphan Receptor SXR

2001 • 188 citations

Gene Regulation by Vitamin D3

1998 • 185 citations

Use of the nuclear receptor PXR to predict drug interactions

2000 • 183 citations

The Nuclear Pregnane X Receptor Regulates Xenobiotic Detoxification

2003 • 160 citations

Identification of the rabbit and human cytochromes P-450IIIA as the major enzymes involved in the N-demethylation of diltiazem.

1990 • 158 citations

Plasma 1,25-Dihydroxyvitamin D Levels in Patients Receiving Anticonvulsant Drugs

1977 • 134 citations

Vitamin D

1999 • 130 citations

Rifampicin and vitamin D metabolism

1980 • 102 citations

Induction of CYP3A4 by 1 alpha,25-dihydroxyvitamin D3 is human cell line-specific and is unlikely to involve pregnane X receptor.

2001 • 100 citations

Effects of anti-epileptic drug therapy on bone mineral density in ambulatory epileptic children

1994 • 97 citations

Regulation of vitamin D-1alpha-hydroxylase and -24-hydroxylase expression by dexamethasone in mouse kidney

2000 • 96 citations

Effect of rifampicin and isoniazid on vitamin D metabolism

1982 • 95 citations

Mechanism of vitamin D action and its regulation

1998 • 91 citations

Retinoid X Receptor (RXR) Ligands Activate the Human 25-Hydroxyvitamin D3-24-hydroxylase Promoter via RXR Heterodimer Binding to Two Vitamin D-responsive Elements and Elicit Additive Effects with 1,25-Dihydroxyvitamin D3

1997 • 89 citations

Emerging Bone Problems in Patients Infected with Human Immunodeficiency Virus

2003 • 88 citations

Relationship Between Low Bone Mineral Density and Highly Active Antiretroviral Therapy Including Protease Inhibitors in HIV-Infected Patients

2003 • 84 citations

Overview of regulatory cytochrome P450 enzymes of the vitamin D pathway

2001 • 83 citations

Cytochrome P450 enzymes in the bioactivation of vitamin D to its hormonal form (Review)

2001 • 70 citations

Deficient Mineralization of Intramembranous Bone in Vitamin D-24-Hydroxylase-Ablated Mice Is Due to Elevated 1,25-Dihydroxyvitamin D and Not to the Absence of 24,25-Dihydroxyvitamin D

2000 • 66 citations

Biochemical evidence for osteomalacia with carbamazepine therapy

2009 • 65 citations

Carbamazepine treatment induces the CYP3A4 catalysed sulphoxidation of omeprazole, but has no or less effect on hydroxylation via CYP2C19

1997 • 61 citations

Calcitriol regulates the expression of the genes encoding the three key vitamin D₃ hydroxylases and the drug‐metabolizing enzyme CYP3A4 in the human fetal intestine

2003 • 58 citations

Orphan nuclear receptor binding site in the human inducible nitric oxide synthase promoter mediates responsiveness to steroid and xenobiotic ligands

2002 • 57 citations

Activation of Vitamin D Receptor by the Wilms' Tumor GeneProduct Mediates Apoptosis of Renal Cells

2001 • 56 citations

Bone Disorders in Human Immunodeficiency Virus Infection

2003 • 55 citations

Pharmaceutical use of mouse models humanized for the xenobiotic receptor

2002 • 50 citations

Rifampicin induced osteomalacia

1981 • 49 citations

The effects of anticonvulsant drugs on vitamin D3-activating cytochrome P-450-linked monooxygenase systems

1991 • 34 citations

Vitamin D receptor ontogenesis in rat liver

1999 • 31 citations

Structure, solvation, and bonding in pentacyano(L)ferrate(II) ions (L=aliphatic amine): a density functional study

2001 • 26 citations

[Drug-induced osteomalacia].

1998 • 25 citations

The mechanisms of regulation of vitamin D metabolism in kidney

1994 • 22 citations

The concept of multiple vitamin D signaling pathways.

1996 • 20 citations

The Influence of Phenobarbital on Biotransformation of 25‐Hydroxycholecalciferol

1976 • 13 citations

Osteomalacia during rifampicin and isoniazid therapy is rare in Hong Kong.

1996 • 10 citations

[Osteomalacia and antiepileptic drugs: study on the pathogenesis].

1975 • 1 citations