Proteomics — the protein expression technology to study connective tissue biology

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

High resolution two-dimensional electrophoresis of proteins.

1975 • 19,515 citations

Mass Spectrometric Sequencing of Proteins from Silver-Stained Polyacrylamide Gels

1996 • 8,994 citations

SUBEPITHELIAL FIBROSIS IN THE BRONCHI OF ASTHMATICS

1989 • 1,151 citations

Sample purification and preparation technique based on nano-scale reversed-phase columns for the sensitive analysis of complex peptide mixtures by matrix-assisted laser desorption/ionization mass spectrometry

1999 • 672 citations

Myofibroblasts and Subepithelial Fibrosis in Bronchial Asthma

1990 • 670 citations

Transforming growth factor β (TGFβ) causes a persistent increase in steady-state amounts of type I and type III collagen and fibronectin mRNAs in normal human dermal fibroblasts

1987 • 579 citations

Proteome Research: New Frontiers in Functional Genomics

1997 • 484 citations

Transforming Growth Factor-β1 Promotes the Morphological and Functional Differentiation of the Myofibroblast

2000 • 466 citations

Airways Remodeling Is a Distinctive Feature of Asthma and Is Related to Severity of Disease

1997 • 396 citations

Induction of alpha-smooth muscle actin expression and myofibroblast transformation in cultured corneal keratocytes.

1996 • 299 citations

On the mechanism of mucosal folding in normal and asthmatic airways

1997 • 269 citations

Bronchial Subepithelial Fibrosis Correlates With Airway Responsiveness to Methacholine

1997 • 254 citations

A post-genomic challenge: learning to read patterns of protein synthesis

1999 • 231 citations

Lung fibroblast alpha-smooth muscle actin expression and contractile phenotype in bleomycin-induced pulmonary fibrosis.

1996 • 230 citations

Altered expression of small proteoglycans, collagen, and transforming growth factor-beta 1 in developing bleomycin-induced pulmonary fibrosis in rats.

1993 • 227 citations

Induction of ??-Smooth Muscle Actin Expression and Myofibroblast Transformation in Cultured Corneal Keratocytes

1996 • 213 citations

Syndecans, Heparan Sulfate Proteoglycans, Maintain the Proteolytic Balance of Acute Wound Fluids

1998 • 196 citations

Airway responsiveness and bronchial-wall thickness in asthma with or without fixed airflow obstruction.

1995 • 188 citations

Transforming growth factor(beta)-mediated corneal myofibroblast differentiation requires actin and fibronectin assembly.

1999 • 181 citations

Independent modulation of collagen fibrillogenesis by decorin and lumican

2000 • 151 citations

Bronchial responsiveness to distilled water and methacholine and its relationship to inflammation and remodeling of the airways in asthma.

1996 • 150 citations

Physical determinants of bronchial mucosal folding

1994 • 140 citations

Structural Requirement of Heparan Sulfate for Interaction with Herpes Simplex Virus Type 1 Virions and Isolated Glycoprotein C

1997 • 140 citations

Characterization of Heparin and Heparan Sulfate Domains Binding to the Long Splice Variant of Platelet-derived Growth Factor A Chain

1997 • 136 citations

Proteome Analysis: A Pathway to the Functional Analysis of Proteins

1999 • 134 citations

Heparin induces alpha-smooth muscle actin expression in cultured fibroblasts and in granulation tissue myofibroblasts.

1992 • 133 citations

Transforming Growth Factor-β Gene Transfer to the Lung Induces Myofibroblast Presence and Pulmonary Fibrosis

1999 • 98 citations

Differential expressions of mRNA for proteoglycans, collagens and transforming growth factor-β in the human cervix during pregnancy and involution

1998 • 89 citations

The Synthesis of a Family of Structurally Related Proteoglycans in Fibroblasts is Differently Regulated by TGF-β

1991 • 86 citations

The Deletion of Transforming Growth Factor-β-Induced Myofibroblasts Depends on Growth Conditions and Actin Organization

1999 • 72 citations

Alteration of proteoglycan synthesis in human lung fibroblasts induced by interleukin-1? and tumor necrosis factor-?

2000 • 64 citations

Fibrosis and airway remodelling

2000 • 62 citations

TGFβ1 autocrine growth control in isolated pancreatic fibroblastoid cells/stellate cells in vitro

2000 • 62 citations

Cytokine regulation of proteoglycan production in fibroblasts: separate and synergistic effects

1997 • 57 citations

Identification of the core proteins in proteoglycans synthesized by vascular endothelial cells

1989 • 54 citations

Proteoglycans in granulomatous lung diseases

1997 • 45 citations

Altered dermatan sulfate proteoglycan synthesis in fibroblast cultures established from skin of patients with systemic sclerosis.

1996 • 22 citations

Heparan sulfate upregulates platelet-derived growth factor receptors on human lung fibroblasts

1998 • 18 citations

Transforming growth factor β1 increases the expressions of high molecular weight tropomyosin isoforms and vinculin and suppresses the transformed phenotypes in human lung carcinoma cells

1997 • 12 citations

Mucosal Folding and Airway Smooth Muscle Shortening

1995 • 7 citations

cAMP and bFGF negatively regulate tropomyosin expression in rat cultured astroblasts

1994 • 6 citations