Heparan sulfate upregulates platelet-derived growth factor receptors on human lung fibroblasts

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

PLATELET-DERIVED GROWTH FACTOR

1989 • 967 citations

cDNA sequence and chromosomal localization of human platelet-derived growth factor A-chain and its expression in tumour cell lines

1986 • 786 citations

Determination of cell number in monolayer cultures

1986 • 646 citations

Protein Kinase C δ Activates the MEK-ERK Pathway in a Manner Independent of Ras and Dependent on Raf

1996 • 570 citations

Activating and inhibitory heparin sequences for FGF-2 (basic FGF). Distinct requirements for FGF-1, FGF-2, and FGF-4.

1993 • 542 citations

cDNA cloning and expression of the human A-type platelet-derived growth factor (PDGF) receptor establishes structural similarity to the B-type PDGF receptor.

1989 • 413 citations

Binding and internalization of heparin by vascular smooth muscle cells

1985 • 298 citations

Cultured human endothelial cells express platelet-derived growth factor B chain: cDNA cloning and structural analysis

1985 • 286 citations

A unique heparan sulfate in the nuclei of hepatocytes: structural changes with the growth state of the cells.

1986 • 260 citations

Differential structural requirements of heparin and heparan sulfate proteoglycans that promote binding of basic fibroblast growth factor to its receptor.

1994 • 254 citations

Induced expression of syndecan in healing wounds.

1991 • 249 citations

Altered expression of small proteoglycans, collagen, and transforming growth factor-beta 1 in developing bleomycin-induced pulmonary fibrosis in rats.

1993 • 227 citations

Extracellular matrix alters PDGF regulation of fibroblast integrins.

1996 • 225 citations

Specific heparan sulfate saccharides mediate the activity of basic fibroblast growth factor.

1994 • 202 citations

Platelet‐derived Growth Factor

1995 • 200 citations

Compartmentalization of PDGF on extracellular binding sites dependent on exon-6-encoded sequences.

1992 • 179 citations

Heparin suppresses mesangial cell proliferation and matrix expansion in experimental mesangioproliferative glomerulonephritis

1993 • 170 citations

Platelet-derived growth factor. Specific binding to target cells.

1982 • 163 citations

Characterization of Heparin and Heparan Sulfate Domains Binding to the Long Splice Variant of Platelet-derived Growth Factor A Chain

1997 • 136 citations

Heparin inhibits c-fos and c-myc mRNA expression in vascular smooth muscle cells.

1990 • 124 citations

Trans-repressor activity of nuclear glycosaminoglycans on Fos and Jun/AP-1 oncoprotein-mediated transcription.

1992 • 121 citations

Heparin suppresses the induction of c-fos and c-myc mRNA in murine fibroblasts by selective inhibition of a protein kinase C-dependent pathway.

1989 • 116 citations

Structural Determinants of Heparin's Growth Inhibitory Activity

1989 • 107 citations

Proliferation of cultured fibroblasts is inhibited by<scp>L</scp>‐Iduronate—containing glycosaminoglycans

1991 • 105 citations

Heparin inhibits mitogen-activated protein kinase activation in intact rat vascular smooth muscle cells.

1993 • 97 citations

Accumulation of PDGF B and cell-binding forms of PDGF A in the extracellular matrix.

1993 • 93 citations

Simultaneous induction of stimulatory and inhibitory signals by PDGF

1997 • 82 citations

Structural studies on heparan sulphates. Characterization of oligosaccharides; obtained by periodate oxidation and alkaline elimination.

1980 • 66 citations

Mechanisms of inhibition by heparin of PDGF stimulated MAP kinase activation in vascular smooth muscle cells

1997 • 61 citations

Protein Kinase C α Expression Is Required for Heparin Inhibition of Rat Smooth Muscle Cell Proliferation in Vitro and in Vivo

1996 • 61 citations

Heparin Inhibits Mitogen-activated Protein Kinase-dependent and -independent c- Induction in Mesangial Cells

1996 • 58 citations

Interleukin 1 beta (IL-1 beta) and the IL-1 beta-alpha 2-macroglobulin complex upregulate the platelet-derived growth factor alpha-receptor on rat pulmonary fibroblasts.

1995 • 53 citations

Structural Studies on Heparan Sulphates

1980 • 52 citations

L-Iduronate-Rich Glycosaminoglycans Inhibit Growth of Normal Fibroblasts Independently of Serum or Added Growth Factors

1993 • 44 citations

Nuclear localization of glycosaminoglycans in rat ovarian granulosa cells.

1994 • 43 citations

Binding, internalization and degradation of heparin and heparin fragments by cultured endothelial cells

1988 • 26 citations

Binding and internalization of exogenous glycosaminoglycans in weakly and highly metastatic rhabdomyosarcoma cells

1989 • 14 citations

Binding, internalization, and degradation of antiproliferative heparan sulfate by human embryonic lung fibroblasts

1997 • 14 citations