T Cells with Multiple Specificities

MHC-Restricted Cytotoxic T Cells: Studies on the Biological Role of Polymorphic Major Transplantation Antigens Determining T-Cell Restriction-Specificity, Function, and Responsiveness

1979 • 1,969 citations

A human T cell-specific cDNA clone encodes a protein having extensive homology to immunoglobulin chains

1984 • 1,262 citations

Isolation of cDNA clones encoding T cell-specific membrane-associated proteins

1984 • 1,239 citations

Functional subclasses of T-lymphocytes bearing different Ly antigens. I. The generation of functionally distinct T-cell subclasses is a differentiative process independent of antigen.

1975 • 1,105 citations

Antigen-inducible, H-2-restricted, interleukin-2-producing T cell hybridomas. Lack of independent antigen and H-2 recognition

1981 • 1,048 citations

Characterization of the Murine Antigenic Determinant, Designated L3T4a, Recognized by Monoclonal Antibody GK 1.5: Expression of L3T4a by Functional T Cell Clones Appears to Correlate Primarily with Class II MHC Antigen‐Reactivity

1983 • 1,040 citations

The major histocompatibility complex-restricted antigen receptor on T cells. I. Isolation with a monoclonal antibody.

1983 • 861 citations

Clonotypic structures involved in antigen-specific human T cell function. Relationship to the T3 molecular complex.

1983 • 833 citations

Lymphoid dendritic cells are potent stimulators of the primary mixed leukocyte reaction in mice.

1978 • 791 citations

Sequence relationships between putative T-cell receptor polypeptides and immunoglobulins

1984 • 719 citations

Characterization of a murine monoclonal antibody specific for an allotypic determinant on T cell antigen receptor.

1985 • 676 citations

Complete primary structure of a heterodimeric T-cell receptor deduced from cDNA sequences

1984 • 652 citations

A third rearranged and expressed gene in a clone of cytotoxic T lymphocytes

1984 • 528 citations

Tumor-specific antigen of murine T-lymphoma defined with monoclonal antibody.

1982 • 526 citations

Lethal graft-versus-host disease after bone marrow transplantation across minor histocompatibility barriers in mice. Prevention by removing mature T cells from marrow.

1978 • 524 citations

A third type of murine T-cell receptor gene

1984 • 491 citations

Somatic recombination in a murine T-cell receptor gene

1984 • 468 citations

Evidence for the T3-associated 90K heterodimer as the T-cell antigen receptor

1983 • 464 citations

Why do so many lymphocytes respond to major histocompatibility antigens?

1977 • 462 citations

T cell antigen receptors and the immunoglobulin supergene family

1985 • 453 citations

Mouse T cell antigen receptor: Structure and organization of constant and joining gene segments encoding the β polypeptide

1984 • 407 citations

Structure, organization, and somatic rearrangement of T cell gamma genes

1985 • 395 citations

The antigen-specific, major histocompatibility complex-restricted receptor on T cells. VI. An antibody to a receptor allotype.

1984 • 389 citations

Genomic organization and sequence of T-cell receptor β-chain constant- and joining-region genes

1984 • 377 citations

Histocompatibility antigen-activated cytotoxic T lymphocytes. II. Estimates of the frequency and specificity of precursors.

1977 • 357 citations

The major histocompatibility complex-restricted antigen receptor on T cells. II. Role of the L3T4 product.

1983 • 325 citations

Fine specificity of a continuously growing killer cell clone specific for H-Y antigen

1979 • 317 citations

The human t cell antigen receptor is encoded by variable, diversity, and joining gene segments that rearrange to generate a complete V gene

1984 • 306 citations

Possible involvement of the OKT4 molecule in T cell recognition of class II HLA antigens. Evidence from studies of cytotoxic T lymphocytes specific for SB antigens.

1982 • 306 citations

The CBA/N Mouse Strain: An Experimental Model Illustration the Influence of the X-Chromosome on Immunity

1982 • 305 citations

Cross-linking of human T cell receptor proteins: association between the T cell idiotype β subunit and the T3 glycoprotein heavy subunit

1985 • 303 citations

Stimulation of the T3-T cell receptor complex induces a membrane-potential-sensitive calcium influx

1985 • 282 citations

QUANTITATIVE STUDIES ON THE MIXED LYMPHOCYTE INTERACTION IN RATS

1968 • 274 citations

Primary structure of human T-cell receptor α-chain

1984 • 245 citations

Structure, expression and divergence of T-cell receptor β-chain variable regions

1984 • 237 citations

Analysis of cDNA clones specific for human T cells and the alpha and beta chains of the T-cell receptor heterodimer from a human T-cell line.

1985 • 225 citations

The mouse T cell receptor: Structural heterogeneity of molecules of normal T cells defined by Xenoantiserum

1983 • 217 citations

The major histocompatibility complex-restricted antigen receptor on T cells in mouse and man: Identification of constant and variable peptides

1983 • 209 citations

Clonal Heterogeneity in the Functional Requirement for Lyt‐2/3 Molecules on Cytolytic T Lymphocytes (CTL): Possible Implications for the Affinity of CTL Antigen Receptors

1982 • 204 citations

High determinant density may explain the phenomenon of alloreactivity

1984 • 194 citations

QUANTITATIVE STUDIES ON THE MIXED LYMPHOCYTE INTERACTION IN RATS

1970 • 186 citations

Limited diversity of the rearranged T-cell γ gene

1985 • 185 citations

Rearrangement and transcription of the β-chain genes of the T-cell antigen receptor in different types of murine lymphocytes

1985 • 172 citations

Contribution of antigen-presenting cell major histocompatibility complex gene products to the specificity of antigen-induced T cell activation

1982 • 170 citations

Immune responses in vitro

1972 • 168 citations

The delineation of antigen receptors on human T lymphocytes

1983 • 162 citations

Immunogenetic and Biological Aspects of in Vitro Lymphocyte Allotransformation (MLR) in the Mouse

1973 • 159 citations

A synaptic basis for T-lymphocyte activation

1984 • 149 citations

Early cellular events in a systemic graft-vs.-host reaction. II. Autoradiographic estimates of the frequency of donor lymphocytes which respond to each Ag-B-determined antigenic complex.

1975 • 148 citations

The Fab fragment of a directly activating monoclonal antibody that precipitates a disulfide-linked heterodimer from a helper T cell clone blocks activation by either allogeneic Ia or antigen and self-Ia.

1984 • 136 citations

Simultaneous expression of H-2-restricted and alloreactive recognition by a cloned line of influenza virus-specific cytotoxic T lymphocytes.

1981 • 128 citations

Immunology: The science of self-nonself discrimination

1983 • 127 citations

Rearranged β t cell receptor genes in a helper t cell clone specific for lysozyme: No correlation between Vβ and MHC restriction

1985 • 120 citations

Models for recognition of virally modified cells by immune thymus-derived lymphocytes

1976 • 111 citations

Characterization of the two heavy chains of the T3 complex on the surface of human T lymphocytes.

1984 • 107 citations

PERTINENT FEATURES OF M LOCUS DETERMINANTS INCLUDING REVISED NOMENCLATURE AND STRAIN DISTRIBUTION

1974 • 104 citations

Peptide variability exists within alpha and beta subunits of the T cell receptor for antigen.

1983 • 101 citations

T lymphocytes responding to Mls-locus antigens are Lyt-1+, 2− andI-A restricted

1980 • 99 citations

Expression of M locus differences by B cells but not T cells

1974 • 97 citations

Histocompatibility antigen-activated cytotoxic T lymphocytes. I. Estimates of the absolute frequency of killer cells generated in vitro.

1977 • 95 citations

The immunobiology of the T cell response to Mls-locus-disparate stimulator cells. I. Unidirectionality, new strain combinations, and the role of Ia antigens.

1985 • 85 citations

Specificity of T-cell clones illustrates altered self hypothesis

1981 • 82 citations

Identification of antigen receptor-associated structures on murine T cells

1985 • 81 citations

Characterization of the stimulator cells in the murine primary mixed leukocyte response.

1980 • 78 citations

Xenogeneic human anti-mouse T cell responses are due to the activity of the same functional T cell subsets responsible for allospecific and major histocompatibility complex-restricted responses.

1983 • 77 citations

Vβ gene polymorphism and a major polyclonal T cell receptor idiotype

1985 • 75 citations

Interaction of thymus lymphocytes with histoincompatible cells

1972 • 74 citations

Specific lymphocyte-activating determinants expressed on mouse macrophages

1975 • 67 citations

T lymphocyte responses to Mls locus antigens involve recognition of H-2 I region gene products

1977 • 65 citations

The immunobiology of T cell responses to Mls-locus-disparate stimulator cells. II. Effects of Mls-locus-disparate stimulator cells on cloned, protein antigen-specific, Ia-restricted T cell lines.

1985 • 65 citations

The regulation of the immune system

1984 • 64 citations

T-cell receptors generated via mutations are specific for various major histocompatibility antigens

1984 • 61 citations

Serologically undetectable immune responses in transplantation.

1972 • 60 citations

T cell clones with dual specificity for M1s and various major histocompatibility complex determinants.

1981 • 60 citations

T cell responses to Mls determinants are restricted by cross-reactive MHC determinants.

1985 • 60 citations

Absence of H-2 restriction in primary and secondary mixed-lymphocyte reactions to strong M1s determinants.

1980 • 57 citations

Heterogeneity of stimulator cells in the murine mixed leukocyte response

1982 • 57 citations

The T-cell receptor mediating restrictive recognition of antigen

1983 • 57 citations

Capacity of small B cell‐enriched populations to stimulate mixed lymphocyte reactions: marked differences between irradiated vs. mitomycin C‐treated stimulators

1985 • 51 citations

Specificity of T cell clones for antigen and autologous major histocompatibility complex products determines specificity for foreign major histocompatibility complex products.

1983 • 51 citations

Studies on non-H-2-linked lymphocyte-activating determinants. II. Nonexpression of Mls determinants in a mouse strain with an X-linked B lymphocyte immune defect.

1976 • 51 citations

T cell proliferation in the mixed lymphocyte culture does not necessarily result in the generation of cytotoxic T effector cells

1975 • 50 citations

Autologous and Syngeneic Mixed Lymphocyte Reactions and Their Immunological Significance1

2015 • 48 citations

Enumeration of alloreactive helper T lymphocytes which cooperate with cytolytic T lymphocytes

1981 • 42 citations

MHC recognition by clones of Mls specific T-lymphocytes

1982 • 42 citations

A one and a half receptor model for MHC-restricted antigen recognition by T lymphocytes

1985 • 41 citations

T cell recognition in the mixed lymphocyte response. II. Ia-positive splenic adherent cells are required for non-I region-induced stimulation.

1981 • 36 citations

Genetic studies and effect on skin allograft survival of DBA-2 DAG, Ly, and M-locus antigens.

1973 • 31 citations

The specificity of the syngeneic mixed leukocyte response, a primary anti-I region T cell proliferative response, is determined intrathymically.

1982 • 30 citations

EVIDENCE THAT STRONG Mls DETERMINANTS ARE NONPOLYMORPHIC1

1981 • 27 citations

STUDIES ON NON‐H‐2 LINKED LYMPHOCYTE ACTIVATING DETERMINANTS I. DESCRIPTION OF THE CELL TYPE BEARING THE MLS PRODUCT

1977 • 27 citations

The Use of Antisera and Monoclonal Antibodies to Identify the Antigen‐specific T Cell Receptor from Pigeon Cytochrome c‐Specific T Cell Hybrids

1983 • 25 citations

T cell receptors for responses to Mls determinants and allo-H-2 determinants appear to be encoded on different chromosomes.

1985 • 24 citations

The role of H-2 in T cell recognition of Mls.

1981 • 24 citations

MIs locus recognition by a cloned line of H-2-restricted influenza virus-specific cytotoxic T lymphocytes.

1981 • 24 citations

Analysis of cross-reactive antigen-specific T cell clones. Specific recognition of two major histocompatibility complex (MHC) and two non-MHC antigens by a single clone.

1983 • 22 citations

T cell lines with dual specificity for strong Mls and H-2 determinants.

1980 • 21 citations

Studies on non-H-2-linked lymphocyte-activating determinants

1977 • 21 citations

Interaction of thymus lymphocytes with histoincompatible cells

1974 • 19 citations

Independent inhibition of IL 2 synthesis and cell proliferation by anti‐Ia antibodies in mixed lymphocyte responses to Mls

1984 • 19 citations

ANALYSIS OF UNEXPECTED INHIBITIONS OF T LYMPHOCYTE PROLIFERATION TO SOLUBLE ANTIGEN, ALLOANTIGEN AND MITOGEN BY UNFRAGMENTED ANTI‐I‐A^k OR ANTI‐I‐E/C^k MONOCLONAL ANTIBODIES

1982 • 18 citations

On the Possibility of Multiple T-cell Receptors

1977 • 17 citations

Further genetic and serological analysis of the LyM-1 alloantigenic system

1977 • 17 citations

Studies on the syngeneic mixed lymphocyte reaction. III. Development of a monoclonal antibody with specificity for autoreactive T cells.

1983 • 17 citations

Immunologic effects of whole-body ultraviolet (uv) irradiation

1981 • 15 citations

Evidence for a new lymphocyte‐stimulating determinant (Lsd) detected by alloreactive T cell lines

1983 • 15 citations

Alloreactivity of Antigen-Specific T Cell Clones

1982 • 15 citations

Cross-reactivity exists between Mlsa and Mlsd lymphocyte-activating determinants as demonstrated by the negative clonal selection of responder cells in a mixed lymphocyte reaction.

1979 • 15 citations

Role of Ia-positive cells in the production of T cell-replacing factors: blocking of factor production with anti-Ia serum.

1980 • 14 citations

Isolation and characterization of an I-A-restricted T cell clone with dual specificity for poly(Glu60Ala30Tyr10) (GAT) and Mlsa,dl.

1984 • 13 citations

The lymphocyte membrane

1984 • 12 citations

Antigen recognition by a T cell clone outside the context of the major histocompatibility complex. A role for Mls in antigen presentation.

1984 • 10 citations

A study of histocompatibility-2 antigens in wild mice from Santiago, Chile

1977 • 9 citations

Immune responses in vitro

1984 • 7 citations

Negative selection in vivo reveals expression of strong Mls determinants in mice with X-linked immunodeficiency.

1984 • 7 citations

HOW DO THYMIC H-2 DETERMINANTS CONTROL T CELL DEVELOPMENT AND WHAT IS THE SIGNIFICANCE OF ALLOREACTIVITY

1980 • 1 citations