Thalidomide exerts its inhibitory action on tumor necrosis factor alpha by enhancing mRNA degradation.

A conserved AU sequence from the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation

1986 • 4,200 citations

Inducibility of κ immunoglobulin enhancer-binding protein NF-κB by a posttranslational mechanism

1986 • 2,043 citations

Control of Cachectin (Tumor Necrosis Factor) Synthesis: Mechanisms of Endotoxin Resistance

1986 • 1,305 citations

Isolation and Characterization of Full-Length cDNA Clones for Human α-, β-, and γ-Actin mRNAs: Skeletal but Not Cytoplasmic Actins Have an Amino-Terminal Cysteine that Is Subsequently Removed

1983 • 1,220 citations

Thalidomide selectively inhibits tumor necrosis factor alpha production by stimulated human monocytes.

1991 • 1,209 citations

Regulation of Lymphokine Messenger RNA Stability by a Surface-Mediated T Cell Activation Pathway

1989 • 910 citations

Antibodies to cachectin/tumor necrosis factor reduce interleukin 1 beta and interleukin 6 appearance during lethal bacteremia.

1989 • 651 citations

Dexamethasone and pentoxifylline inhibit endotoxin-induced cachectin/tumor necrosis factor synthesis at separate points in the signaling pathway.

1990 • 509 citations

Endotoxin-responsive sequences control cachectin/tumor necrosis factor biosynthesis at the translational level.

1990 • 495 citations

Phagocytosis and inflammatory stimuli induce GM-CSF mRNA in macrophages through posttranscriptional regulation

1987 • 377 citations

Pentoxifylline suppression of tumor necrosis factor gene transcription.

1991 • 316 citations

Transcriptional and posttranscriptional regulation of tumor necrosis factor gene expression in human monocytes.

1988 • 227 citations

Serum levels of tumour necrosis factor-alpha and interleukin-1 beta during leprosy reactional states.

1991 • 195 citations

The Common Mediator of Shock, Cachexia, and Tumor Necrosis

1988 • 175 citations

Prolonged treatment with recombinant interferon gamma induces erythema nodosum leprosum in lepromatous leprosy patients.

1992 • 160 citations

Interactive effects of the tumor necrosis factor promoter and 3'-untranslated regions.

1991 • 153 citations

Transcriptional and post-transcriptional mechanisms involved in the differential expression of LPS-induced IL-1 and TNF mRNA.

1991 • 73 citations

Increased cyclic AMP levels enhance IL-1 alpha and IL-1 beta mRNA expression and protein production in human myelomonocytic cell lines and monocytes.

1991 • 42 citations