Relapse cell population differs from acute onset clone as shown by absence of the initially activated N-ras oncogene in a patient with acute myelomonocytic leukemia

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

Enzymatic Amplification of β-Globin Genomic Sequences and Restriction Site Analysis for Diagnosis of Sickle Cell Anemia

1985 • 9,128 citations

Prevalence of ras gene mutations in human colorectal cancers

1987 • 1,866 citations

Detection of high incidence of K-ras oncogenes during human colon tumorigenesis

1987 • 1,074 citations

Carcinogen-specific mutation and amplification of Ha-ras during mouse skin carcinogenesis

1986 • 865 citations

Direct mutagenesis of Ha-ras-1 oncogenes by N-nitroso-N-methylurea during initiation of mammary carcinogenesis in rats

1985 • 829 citations

Lineage promiscuity in hemopoietic differentiation and leukemia

1986 • 572 citations

Activation of the mouse cellular Harvey-ras gene in chemically induced benign skin papillomas

1984 • 550 citations

Structure and activation of the human N-ras gene

1983 • 538 citations

Analysis of RAS gene mutations in acute myeloid leukemia by polymerase chain reaction and oligonucleotide probes.

1988 • 367 citations

Transforming ras genes from human melanoma: a manifestation of tumour heterogeneity?

1984 • 322 citations

Clonal Development, Stem-Cell Differentiation, and Clinical Remissions in Acute Nonlymphocytic Leukemia

1987 • 319 citations

Differentiation of Leukemia Cells to Polymorphonuclear Leukocytes in Patients with Acute Nonlymphocytic Leukemia

1986 • 298 citations

NIH/3T3 cells transfected with human tumor DNA containing activated ras oncogenes express the metastatic phenotype in nude mice.

1985 • 240 citations

Mutations in N-ras predominate in acute myeloid leukemia

1987 • 239 citations

A point mutation at codon 13 of the N-ras oncogene in myelodysplastic syndrome

1987 • 231 citations

Activation of a c-K- ras Oncogene by Somatic Mutation in Mouse Lymphomas Induced by Gamma Radiation

1984 • 180 citations

Transforming genes of human hematopoietic tumors: frequent detection of ras-related oncogenes whose activation appears to be independent of tumor phenotype.

1983 • 172 citations

Mutations of the Kirsten-ras proto-oncogene in human preleukaemia

1987 • 146 citations

An Activated ras ^N Gene: Detected in Late But Not Early Passage Human PA1 Teratocarcinoma Cells

1984 • 131 citations

Three different activated ras genes in mouse tumours; evidence for oncogene activation during progression of a mouse lymphoma.

1984 • 97 citations

Identification of an activated c-Ki-ras oncogene in rat liver tumors induced by aflatoxin B1.

1986 • 97 citations

High frequency of N-ras activation in acute myelogenous leukemia

1986 • 82 citations

Enhanced spontaneous metastasis of mouse carcinoma cells transfected with an activated c‐Ha‐ras‐1 gene

1986 • 79 citations

Normal and activated ras oncogenes and their encoded products

1986 • 72 citations

Expression of normal and mutant ras proteins in human acute leukemia.

1987 • 64 citations

Activation of N-ras gene in bone marrow cells from a patient with acute myeloblastic leukaemia

1984 • 58 citations

Mutation analysis of the N‐ras proto‐oncogene in active and remission phase of human acute leukemias

1988 • 51 citations

Identification by transfection of transforming sequences in DNA of human T-cell leukemias.

1983 • 43 citations

Oncogene activation in human myeloid leukemia.

1985 • 42 citations

Restriction endonucleasesHindIIandTaqIcleave DNA with mismatched nucleotides within their recognition sequences

1986 • 20 citations