Heat shock proteins: friend and foe?

THE HEAT-SHOCK PROTEINS

1988 • 5,214 citations

Protein synthesis in salivary glands of Drosophila melanogaster: Relation to chromosome puffs

1974 • 1,189 citations

Heat shock proteins and the immune response

1990 • 944 citations

Mitochondrial heat-shock protein hsp60 is essential for assembly of proteins imported into yeast mitochondria

1989 • 933 citations

Cloning of the mycobacterial epitope recognized by T lymphocytes in adjuvant arthritis

1988 • 838 citations

Is hsp70 the cellular thermometer?

1991 • 586 citations

Isolation of CD4-CD8-mycobacteria-reactive T lymphocyte clones from rheumatoid arthritis synovial fluid

1989 • 543 citations

Autoimmunity, microbial immunity and the immunological homunculus

1991 • 525 citations

Primary structure of a human mitochondrial protein homologous to the bacterial and plant chaperonins and to the 65-kilodalton mycobacterial antigen.

1989 • 492 citations

Stimulation of a major subset of lymphocytes expressing T cell receptor γδ by an antigen derived from mycobacterium tuberculosis

1989 • 491 citations

Human γδ+ T cells respond to mycobacterial heat-shock protein

1989 • 417 citations

Vaccination against autoimmune mouse diabetes with a T-cell epitope of the human 65-kDa heat shock protein.

1991 • 384 citations

SYNOVIAL FLUID T CELL REACTIVITY AGAINST 65 kD HEAT SHOCK PROTEIN OF MYCOBACTERIA IN EARLY CHRONIC ARTHRITIS

1988 • 311 citations

Stress proteins may provide a link between the immune response to infection and autoimmunity

1989 • 264 citations

A role for heat shock proteins in inflammation?

1988 • 262 citations

T lymphocytes from healthy individuals with specificity to self-epitopes shared by the mycobacterial and human 65-kilodalton heat shock protein.

1989 • 237 citations

Enumeration of T cells reactive with Mycobacterium tuberculosis organisms and specific for the recombinant mycobacterial 64‐kDa protein

1987 • 216 citations

Recognition of human 60 kD heat shock protein by mononuclear cells from patients with juvenile chronic arthritis

1991 • 199 citations

Autoantibodies to the constitutive 73-kD member of the hsp70 family of heat shock proteins in systemic lupus erythematosus.

1988 • 186 citations

Recognition of a mycobacteria-specific epitope in the 65-kD heat-shock protein by synovial fluid-derived T cell clones.

1990 • 168 citations

Autoantibodies to the heat-shock protein hsp90 in systemic lupus erythematosus.

1988 • 158 citations

Mapping of T cell epitopes using recombinant antigens and synthetic peptides.

1987 • 152 citations

A recombinant 64 kilodalton protein of Mycobacterium bovis bacillus Calmette-Guerin specifically stimulates human T4 clones reactive to mycobacterial antigens.

1986 • 146 citations

Primary Structure of a Human Mitochondrial Protein Homologous to the Bacterial and Plant Chaperonins and to the 65-Kilodalton Mycobacterial Antigen

1989 • 144 citations

Steroid hormone antagonists at the receptor level: A role for the heat‐shock protein MW 90,000 (hsp 90)

1987 • 143 citations

Raised serum IgG and IgA antibodies to mycobacterial antigens in rheumatoid arthritis.

1989 • 142 citations

Presence of Human 65 kD Heat Shock Protein (hsp) in Inflamed Joints and Subcutaneous Nodules of RA Patients

1990 • 135 citations

Elevated IgG Antibody Levels to the Mycobacterial 65‐kDa Heat Shock Protein Are Characteristic of Patients with Rheumatoid Arthritis

1989 • 103 citations

Use of recombinant antigens expressed in Escherichia coli K-12 to map B-cell and T-cell epitopes on the immunodominant 65-kilodalton protein of Mycobacterium bovis BCG

1988 • 101 citations

T cell responses of normal individuals towards recombinant protein antigens of Mycobacterium tuberculosis

1988 • 74 citations

AMycobacterium leprae-Specific Human T Cell Epitope Cross-Reactive with an HLA-DR2 Peptide

1988 • 67 citations

In Vitro Mitogen Stimulation of Synovial Fluid Lymphocytes from Rheumatoid Arthritis and Juvenile Rheumatoid Arthritis Patients: Dissociation between the Response to Antigens and Polyclonal Mitogens

1978 • 65 citations

A Mycobacterial Heat-Shock Protein-Responsive T Cell Clone Also Responds to the Homologous Human Heat-Shock Protein: A Possible Link between Infection and Autoimmunity

1991 • 62 citations

Epitopes of the Mycobacterium tuberculosis 65-kilodalton protein antigen as recognized by human T cells.

1988 • 59 citations

High antigen reactivity in mononuclear cells from sites of chronic inflammation

1990 • 56 citations

A new serologic marker in ankylosing spondylitis

1984 • 28 citations

Murine and human B cell epitope mapping of the Mycobacterium tuberculosis 10-kD heat shock protein using overlapping peptides

1991 • 19 citations

Carrier Effect of Concanavalin A‐Reactive and ‐Non‐Reactive Material in Tuberculin PPD

1990 • 16 citations