RSUME, a Small RWD-Containing Protein, Enhances SUMO Conjugation and Stabilizes HIF-1α during Hypoxia

Targeting HIF-1 for cancer therapy

2003 • 6,321 citations

Nuclear factor-κB in cancer development and progression

2006 • 3,334 citations

Regulation of hypoxia-inducible factor 1α is mediated by an O ₂ -dependent degradation domain via the ubiquitin-proteasome pathway

1998 • 2,044 citations

Hypoxia Response Elements in the Aldolase A, Enolase 1, and Lactate Dehydrogenase A Gene Promoters Contain Essential Binding Sites for Hypoxia-inducible Factor 1

1996 • 1,660 citations

Hypoxia signalling in cancer and approaches to enforce tumour regression

2006 • 1,603 citations

SUMO

2005 • 1,562 citations

SUMO-1 Modification of IκBα Inhibits NF-κB Activation

1998 • 1,002 citations

Hypoxia-inducible factor (HIF-1)α: its protein stability and biological functions

2004 • 969 citations

Functional Heterogeneity of Small Ubiquitin-related Protein Modifiers SUMO-1 versus SUMO-2/3

2000 • 848 citations

The Nucleoporin RanBP2 Has SUMO1 E3 Ligase Activity

2002 • 787 citations

Polymeric Chains of SUMO-2 and SUMO-3 Are Conjugated to Protein Substrates by SAE1/SAE2 and Ubc9

2001 • 782 citations

SUMO—Nonclassical Ubiquitin

2000 • 764 citations

SUMO and ubiquitin in the nucleus: different functions, similar mechanisms?

2004 • 744 citations

SUMO-1 Conjugation in Vivo Requires Both a Consensus Modification Motif and Nuclear Targeting

2001 • 722 citations

An E3-like Factor that Promotes SUMO Conjugation to the Yeast Septins

2001 • 642 citations

Non-hypoxic pathway mediates the induction of hypoxia inducible factor 1 alpha (HIF-1 alpha ) in vascular smooth muscle cells

2000 • 592 citations

The SUMO Pathway Is Essential for Nuclear Integrity and Chromosome Segregation in Mice

2005 • 515 citations

Insights into E3 ligase activity revealed by a SUMO–RanGAP1–Ubc9–Nup358 complex

2005 • 473 citations

Induction of interleukin-8 preserves the angiogenic response in HIF-1α–deficient colon cancer cells

2005 • 400 citations

A functional variant of SUMO4, a new IκBα modifier, is associated with type 1 diabetes

2004 • 399 citations

SUMO: ligases, isopeptidases and nuclear pores

2003 • 387 citations

Ubch9 conjugates SUMO but not ubiquitin

1997 • 349 citations

The Mouse Gene for Vascular Endothelial Growth Factor

1996 • 335 citations

Mms2–Ubc13 covalently bound to ubiquitin reveals the structural basis of linkage-specific polyubiquitin chain formation

2006 • 333 citations

A UbcH5/Ubiquitin Noncovalent Complex Is Required for Processive BRCA1-Directed Ubiquitination

2006 • 295 citations

Molecular Insights into Polyubiquitin Chain Assembly

2001 • 289 citations

Angiogenesis: How a Tumor Adapts to Hypoxia

1999 • 282 citations

SP-RING for SUMO

2001 • 279 citations

Activation and Induction of NUR77/NURR1 in Corticotrophs by CRH/cAMP: Involvement of Calcium, Protein Kinase A, and MAPK Pathways

2002 • 264 citations

Sumoylation increases HIF-1α stability and its transcriptional activity

2004 • 212 citations

Basis for a ubiquitin-like protein thioester switch toggling E1–E2 affinity

2007 • 209 citations

Preferential Interaction of Sentrin with a Ubiquitin-conjugating Enzyme, Ubc9

1997 • 190 citations

Phosphorylation of c-Fos by Members of the p38 MAPK Family

2005 • 190 citations

Noncovalent interaction between Ubc9 and SUMO promotes SUMO chain formation

2007 • 187 citations

A Mechanism for Inhibiting the SUMO Pathway

2004 • 179 citations

Involvement of bone morphogenetic protein 4 (BMP-4) in pituitary prolactinoma pathogenesis through a Smad/estrogen receptor crosstalk

2003 • 176 citations

SENP1 Enhances Androgen Receptor-Dependent Transcription through Desumoylation of Histone Deacetylase 1

2004 • 170 citations

The sentrin-conjugating enzyme mUbc9 interacts with GLUT4 and GLUT1 glucose transporters and regulates transporter levels in skeletal muscle cells

2000 • 163 citations

SUMO and transcriptional regulation

2004 • 162 citations

Modification of Ran GTPase-activating Protein by the Small Ubiquitin-related Modifier SUMO-1 Requires Ubc9, an E2-type Ubiquitin-conjugating Enzyme Homologue

1998 • 155 citations

Roles of sumoylation of a reptin chromatin-remodelling complex in cancer metastasis

2006 • 148 citations

Increase of SUMO‐1 expression in response to hypoxia: direct interaction with HIF‐1α in adult mouse brain and heart in vivo

2004 • 146 citations

Protein modification by SUMO

2001 • 137 citations

Structure and Analysis of a Complex between SUMO and Ubc9 Illustrates Features of a Conserved E2-Ubl Interaction

2007 • 129 citations

Hypoxic induction of human visfatin gene is directly mediated by hypoxia‐inducible factor‐1

2006 • 124 citations

Generation of bidirectional hypoxia/HIF-responsive expression vectors to target gene expression to hypoxic cells

2001 • 113 citations

Interleukin-2 and interleukin-2 receptor expression in human corticotrophic adenoma and murine pituitary cell cultures.

1992 • 109 citations

Fas Ligand Induces Cell-autonomous NF-κB Activation and Interleukin-8 Production by a Mechanism Distinct from That of Tumor Necrosis Factor-α

2004 • 103 citations

Corticotropin-releasing hormone activates ERK1/2 MAPK in specific brain areas

2005 • 99 citations

PIAS1 confers DNA-binding specificity on the Msx1 homeoprotein

2006 • 94 citations

GI Domain-mediated Association of the Eukaryotic Initiation Factor 2α Kinase GCN2 with Its Activator GCN1 Is Required for General Amino Acid Control in Budding Yeast

2000 • 74 citations

Solution structure of the RWD domain of the mouse GCN2 protein

2004 • 73 citations

Mechanism Responsible for T-Cell Antigen Receptor- and CD28- or Interleukin 1 (IL-1) Receptor-Initiated Regulation of IL-2 Gene Expression by NF-κB

1998 • 67 citations

Structure of a SUMO-binding-motif Mimic Bound to Smt3p–Ubc9p: Conservation of a Non-covalent Ubiquitin-like Protein–E2 Complex as a Platform for Selective Interactions within a SUMO Pathway

2007 • 61 citations

Reduced Expression of the Cytokine Transducer gp130 Inhibits Hormone Secretion, Cell Growth, and Tumor Development of Pituitary Lactosomatotrophic GH3 Cells

2003 • 36 citations

Up‐regulation of vascular endothelial growth factor in synovial fibroblasts from human temporomandibular joint by hypoxia

2007 • 33 citations