Shift in the Balance between Circulating Thrombospondin-1 and Vascular Endothelial Growth Factor in Cancer Patients: Relationship to Platelet α-Granule Content and Primary Activation

Patterns and Emerging Mechanisms of the Angiogenic Switch during Tumorigenesis

1996 • 6,878 citations

A tumor suppressor-dependent inhibitor of angiogenesis is immunologically and functionally indistinguishable from a fragment of thrombospondin.

1990 • 1,062 citations

Release of the angiogenic cytokine vascular endothelial growth factor (VEGF) from platelets: significance for VEGF measurements and cancer biology

1998 • 608 citations

Clinical Implications of Circulating Angiogenic Factors in Cancer Patients

2001 • 599 citations

Thrombospondin‐1 as an endogenous inhibitor of angiogenesis and tumor growth

2002 • 534 citations

Platelet thrombospondin modulates endothelial cell adhesion, motility, and growth: a potential angiogenesis regulatory factor.

1990 • 407 citations

Platelets and cancer

2002 • 360 citations

The Hemostatic System as a Regulator of Angiogenesis

2000 • 322 citations

Angiogenesis: pathological, prognostic, and growth-factor pathways and their link to trial design and anticancer drugs

2001 • 234 citations

Thrombospondins and tumor angiogenesis

2001 • 173 citations

Platelet number and interleukin-6 correlate with VEGF but not with bFGF serum levels of advanced cancer patients

1999 • 168 citations

Thrombocytes Are the Major Source for Soluble Vascular Endothelial Growth Factor in Peripheral Blood

2000 • 160 citations

Determination of vascular endothelial growth factor (VEGF) in circulating blood: significance of VEGF in various leucocytes and platelets

2002 • 142 citations

Vascular endothelial growth factor measured in platelet poor plasma allows optimal separation between cancer patients and volunteers: A key to study an angiogenic marker in vivo?

1999 • 113 citations

The role of the coagulation system in tumour angiogenesis

2001 • 106 citations

Disturbance of plasma and platelet thrombospondin levels in sickle cell disease

1996 • 105 citations

A critical review of vascular endothelial growth factor (VEGF) analysis in peripheral blood: is the current literature meaningful?

2002 • 96 citations

The interaction of human platelet thrombospondin with fibrinogen. Thrombospondin purification and specificity of interaction.

1985 • 95 citations

A radioimmunoassay for thrombospondin, used in a comparative study of thrombospondin, β-thromboglobulin and platelet factor 4 in healthy volunteers

1983 • 88 citations

Circulating Angiogenesis Regulators in Cancer Patients

2001 • 80 citations

Validation of Blood Collection Procedures for the Determination of Circulating Vascular Endothelial Growth Factor (VEGF) in Different Blood Compartments

2001 • 79 citations

Thrombospondin Levels in Patients with Malignancy

1992 • 78 citations

Plasma thrombospondin levels in patients with gynecologic malignancies

1994 • 56 citations

Plasma thrombospondin levels in patients with colorectal carcinoma

1998 • 50 citations

Monitoring of circulating angiogenic factors in dendritic cell–based cancer immunotherapy

2003 • 19 citations

Do Extra-Platelet Sources Contribute to the Plasma Level of Thrombospondin?

1988 • 17 citations