Antimicrobial Resistance with Focus on β-Lactam Resistance in Gram-Negative Bacilli

A functional classification scheme for beta-lactamases and its correlation with molecular structure

1995 • 2,497 citations

Extended Broad-Spectrum -Lactamases Conferring Transferable Resistance to Newer -Lactam Agents in Enterobacteriaceae: Hospital Prevalence and Susceptibility Patterns

1988 • 1,540 citations

Prevention of Drug Access to Bacterial Targets: Permeability Barriers and Active Efflux

1994 • 1,518 citations

Resistance to Antibiotics Mediated by Target Alterations

1994 • 671 citations

Nosocomial Outbreak of Klebsiella Infection Resistant to Late-Generation Cephalosporins

1993 • 605 citations

Predominant pathogens in hospital infections

1992 • 593 citations

Outer membrane barrier as a mechanism of antimicrobial resistance

1989 • 458 citations

Health and Economic Impacts of Antimicrobial Resistance

1987 • 424 citations

Outbreak of ceftazidime resistance caused by extended-spectrum beta-lactamases at a Massachusetts chronic-care facility

1990 • 394 citations

-Lactam Resistance in Gram-Negative Bacteria: Global Trends and Clinical Impact

1992 • 340 citations

Novel plasmid-mediated beta-lactamase (MIR-1) conferring resistance to oxyimino- and alpha-methoxy beta-lactams in clinical isolates of Klebsiella pneumoniae

1990 • 310 citations

Outbreak of ceftazidime resistance due to a novel extended-spectrum beta-lactamase in isolates from cancer patients

1992 • 197 citations

Penicillin-binding proteins and bacterial resistance to beta-lactams

1993 • 187 citations

In vitro activities of 12 orally administered antimicrobial agents against four species of bacterial respiratory pathogens from U.S. Medical Centers in 1992 and 1993

1994 • 162 citations

Incidence and mechanisms of resistance to the combination of amoxicillin and clavulanic acid in Escherichia coli

1995 • 148 citations

The emergence of epidemic, multiple-antibiotic-resistant Stenotrophomonas (Xanthomonas) maltophilia and Burkholderia (Pseudomonas) cepacia

1995 • 145 citations

Efficacy of Cefepime in the Treatment of Infections Due to Multiply Resistant Enterobacter Species

1996 • 139 citations

Bug/drug resistance. Sometimes less is more.

1989 • 129 citations

Mechanisms of resistance to β-lactam antibiotics amongst Pseudomonas aeruginosa isolates collected in the UK in 1993

1995 • 124 citations

Molecular characterization of nine different types of mutants among 107 inhibitor-resistant TEM beta-lactamases from clinical isolates of Escherichia coli

1995 • 120 citations

-Lactamases of Gram-Negative Bacteria: New Challenges for New Drugs

1992 • 117 citations

Bug/Drug Resistance

1989 • 93 citations

Imipenem resistance in clinical isolates of Proteus mirabilis associated with alterations in penicillin-binding proteins

1995 • 77 citations

Frequency of inhibitor-resistant TEM β-lactamases in Escherichia coli isolates from urinary tract infections in Fran

1994 • 72 citations

Novel plasmid-mediated beta-lactamases in enterobacteriaceae: emerging problems for new beta-lactam antibiotics.

1996 • 48 citations

Imipenem and cephem resistant Pseudomonas aeruginosa carrying plasmids coding for class B β-lactamase

1996 • 48 citations

Mechanisms of resistance to the carbapenems

1995 • 46 citations

β-Lactam susceptibility of Haemophilus influenzae strains showing reduced susceptibility to cefuroxime

1993 • 23 citations