5-Azacytidine: Mechanism of action and biological effects in mammalian cells

Polyamines in Normal and Neoplastic Growth

1976 • 545 citations

Induction of the polyamine-biosynthetic enzymes in mouse epidermis by tumor-promoting agents.

1975 • 504 citations

THE INDUCTION OF ORNITHINE DECARBOXYLASE AS AN EARLY, POSSIBLY OBLIGATORY EVENT IN MOUSE SKIN CARCINOGENESIS

1976 • 353 citations

5-Azacytidine, a new, highly effective cancerostatic

1964 • 261 citations

Cytotoxicity and mode of action of 5-azacytidine on L1210 leukemia.

1970 • 260 citations

Test for carcinogenicity of food additives and chemotherapeutic agents by the pulmonary tumor response in strain A mice.

1973 • 229 citations

Biological Effects of 5-Azacytidine in Eukaryotes

1974 • 198 citations

5-Azacytidine

1976 • 177 citations

Nucleic acids components and their analogues. LI. Synthesis of 1-glycosyl derivatives of 5-azauracil and 5-azacytosine

1964 • 164 citations

Cell cycle phase specificity of antitumor agents.

1972 • 150 citations

5-Azacytidine: A New Active Agent for the Treatment of Acute Leukemia

1973 • 138 citations

Deoxycytidine kinase: properties of the enzyme from human leukemic granulocytes

1975 • 124 citations

Effect of 5-aza-2'-deoxycytidine against leukemic and hemopoietic tissues in AKR mice.

1968 • 114 citations

Kinetics and Mechanisms of Degradation of the Antileukemic Agent 5‐Azacytidine in Aqueous Solutions

1975 • 113 citations

Studies of the enzymatic deamination of ara-cytidine—V

1968 • 113 citations

Effects of cytosine arabinoside, daunomycin, mithramycin, azacytidine, adriamycin, and camptothecin on mammalian cell cycle traverse.

1972 • 106 citations

Synthesis of a 2-deoxy-D-ribofuranosyl-5-azacytosine

1964 • 94 citations

5-Azacytidine (NSC 102816): a new drug for the treatment of myeloblastic leukemia

1976 • 89 citations

Pharmacological Basis of Cancer Chemotherapy.

1975 • 85 citations

Repression and Derepression of Purine Biosynthesis in Mammalian Hepatoma Cells in Culture

1972 • 83 citations

Nucleoside Antibiotics

1970 • 76 citations

THE ACTIVITY OF A NEW ANTIMETABOLITE, 5-AZACYTIDINE, AGAINST LYMPHOID LEUKAEMIA IN AK MICE.

1964 • 76 citations

THE SPECIFICITY OF HYDROGEN BOND FORMATION BETWEEN DERIVATIVES OF NUCLEIC ACID BASES AND SOME ANALOGUES

1966 • 75 citations

Incorporation of a potent antileukemic agent, 5-aza-2'-deoxycytidine, into DNA of cells from leukemic mice.

1977 • 73 citations

Phase specificity of 5-azacytidine against mammalian cells in tissue culture.

1970 • 73 citations

5-azacytidine in acute leukemia

1978 • 72 citations

Chromatid Breakage: Differential Effect of Inhibitors of DNA Synthesis during G ₂ Phase

1972 • 71 citations

Antileukemic effects of pseudoisocytidine, a new synthetic pyrimidine C-nucleoside.

1976 • 69 citations

Deamination of 5-azacytidine by a human leukemia cell cytidine deaminase

1973 • 68 citations

In vitro cytotoxic and biochemical effects of 5-aza-2'-deoxycytidine.

1977 • 66 citations

Inhibition of Ribosomal Ribonucleic Acid Maturation in Rat Liver by 5-Fluoroorotic Acid Resulting in the Selective Labeling of Cytoplasmic Messenger Ribonucleic Acid

1971 • 60 citations

Beta-Lactamase Activity in Ampicillin-Resistant Haemophilus influenzae

1974 • 59 citations

Cerebral cortex of the mouse after prenatal chemical insult

1971 • 57 citations

Hydrocortisone-mediated changes in the concentration of tyrosine transaminase in rat liver: An immunochemical study

1970 • 57 citations

Kinetic studies on phosphorylation of 5-azacytidine with the purified uridine-cytidine kinase from calf thymus.

1974 • 56 citations

Multiple forms of uridine kinase in normal and neoplastic rat liver

1971 • 55 citations

The disposition and pharmacokinetics in humans of 5-azacytidine administered intravenously as a bolus or by continuous infusion.

1976 • 54 citations

Common Receptor-Complement Feature Among Some Antileukemic Compounds

1970 • 54 citations

The mechanism of inhibition of protein synthesis by 5-azacytidine in HeLa cells

1973 • 53 citations

Treatment of acute leukemia with 5-azacytidine (NSC-102816).

1973 • 52 citations

Effects of 5-azacytidine on polyribosomes and on the control of tyrosine transaminase activity in rat liver

1969 • 51 citations

Drug effects on nucleic acid modification. I. A specific effect of 5-azacytidine on mammalian transfer RNA methylation invivo

1976 • 50 citations

Nucleic acids components and their analogues. LXVI. Hydrolysis of 5-azacytidine and its connection with biological activity

1965 • 48 citations

Anabolic transformation of a novel antimetabolite, 5-azacytidine, and evidence for its incorporation into ribonucleic acid

1965 • 47 citations

Association of decreased uridine and deoxycytidine kinase with enhanced RNA and DNA polymerase in mouse leukemic cells resistant to 5-azacytidine and 5-aza-2'-deoxycytidine.

1970 • 47 citations

Comparative chemotherapy of AKR lymphoma and human hematological neoplasia.

1974 • 47 citations

Uridine kinase activities and pyrimidine nucleoside phosphorylation in fluoropyrimidine-sensitive and -resistant cell lines of the Novikoff hepatoma

1977 • 45 citations

Characteristics of mouse leukemic cells resistant to 5-azacytidine and 5-aza-2'-deoxycytidine.

1968 • 45 citations

Biochemical effects and metabolic transformations of 5-azacytidine in Escherichia coli

1965 • 45 citations

Inhibition of protein synthesis in 5-azacytidine-treated HeLa cells

1976 • 43 citations

Phase II study of 5-azacytidine in solid tumors.

1977 • 42 citations

Phase I study of 5-azacytidine (NSC-102816) .

1972 • 41 citations

Microbiological production of 5-azacytidine. I. Production and biological activity.

1966 • 41 citations

Immunosuppression by pyrimidine nucleoside analogs

1966 • 39 citations

Biochemical mechanism of drug resistance—VII

1968 • 36 citations

5-azacytidine in childhood leukemia.

1971 • 33 citations

Nucleosides XCII. A facile synthesis of 5‐(β‐d‐ribofuranosyl)‐ isocytosine (ψ‐isocytidine)

1975 • 32 citations

Depression of polyamine synthesis in L1210 leukemic mice during treatment with a potent antileukemic agent, 5-azacytidine.

1973 • 31 citations

Destructive processing of the 45-S ribosomal precursor in the presence of 5-azacytidine

1973 • 31 citations

Phase II study of 5-azacytidine in solid tumors.

1977 • 30 citations

Modified induction of ornithine decarboxylase by factors which affect liver regeneration

1972 • 30 citations

Biochemical mechanisms of drug resistance IV. Development of resistance to 5‐azacytidine and simultaneous depression of pyrimidine metabolism in leukemic mice

1967 • 29 citations

Metabolic effects of 5-azacytidine in isolated nuclei of calf-thymus cells

1966 • 28 citations

Inhibition of ribosomal ribonucleic acid maturation by 5-azacytidine and 8-azaguanine in Novikoff hepatoma cells

1974 • 27 citations

Inhibition of isoproterenol-stimulated deoxyribonucleic acid synthesis by 5-azacytidine.

1971 • 27 citations

Biochemical changes associated with the development of resistance to 5‐azacytidine in AKR leukemic mice

1966 • 27 citations

Phase I study of 5-azacytidine (NSC-102816) using 24-hour continuous infusion for 5 days.

1975 • 26 citations

Enhanced Uridine Kinase in Rat Liver following 5-Azacytidine Administration

1973 • 25 citations

On the metabolism of 5-azacytidine and 5-aza-2'-deoxycytidine in mice

1965 • 25 citations

Absorption, distribution, and excretion of 5-azacytidine (NSC-102816) in man.

1972 • 25 citations

Incorporation of 5-azacytidine into liver ribonucleic acids of leukemic mice sensitive and resistant to 5-azacytidine

1965 • 25 citations

Effect of 5-azacytidine on developing mouse embryo

1968 • 25 citations

Effects of 5-azacytidine on nucleolar RNA and the preribosomal particles in Novikoff hepatoma cells

1975 • 24 citations

Dual effect of 5-azacytidine on the synthesis of liver ribonucleic acids

1972 • 24 citations

Effect of 5-azacytidine on the acceptor activity of sRNA

1966 • 24 citations

Clinical trial with subcutaneously administered 5-azacytidine (NSC-102816).

1974 • 24 citations

Effect of trna from 5-azacytidine-treated hamster fibrosarcoma cells on protein synthesis in vitro in a cell-free system

1976 • 23 citations

Enhancement by tetrahydrouridine (NSC-112907) of the oral activity of 5-azacytidine (NSC-102816) in L1210 leukemic mice.

1975 • 22 citations

Uridine kinase activities in normal and neoplastic lymphoid cells.

1977 • 22 citations

Differences in the inhibition of hormone and substrate induction of rat liver tryptophan pyrrolase by 5-azacytidine

1967 • 22 citations

Prolongation of the lag period preceding the enhancement of thymidine and thymidylate kinase activity in regenerating rat liver by 5-azacytidine

1972 • 22 citations

Incorporation of 5-azacytidine-4-[14C] and of cytidine-[3H] into ribonucleic acids of mouse Ehrlich ascites tumour cells

1966 • 21 citations

Alteration of ribosomal precursor RNA in Novikoff hepatoma cells by 5-azacytidine

1974 • 20 citations

Tyrosine transaminase induction

1971 • 20 citations

Effect of combination treatment with 5-azacytidine and cytidine on the life-span and spleen and bone marrow cells of leukemic (L1210) and nonleukemic mice.

1970 • 20 citations

Studies on the mechanism of the stimulation of tyrosine aminotransferase activity in vivo by pyrimidine analogs: The role of enzyme synthesis and degradation

1973 • 20 citations

Early temporal changes in the uridine kinase isozyme profile of the novikoff hepatoma in response to 5-azacytidine treatment

1975 • 20 citations

Enhanced uridine kinase and RNA synthesis in regenerating rat liver after 5-azacytidine administration

1972 • 20 citations

5-azacytidine-modified patterns of uridine kinase activities in normal and neoplastic tissues.

1974 • 19 citations

Characterization of polyribosomes and maturation of ribosomal RNA in hepatoma cells treated with 5-azacytidine.

1974 • 19 citations

Dihydro-5-azacytidine hydrochloride, a biologically active and chemically stable analog of 5-azacytidine.

1976 • 18 citations

Thymidine kinase and polyribosome distribution in regenerating rat liver following 5-azacytidine

1968 • 18 citations

Transformation of 5-aza-2′-deoxycytidine-3H and its incorporation in different systems of rapidly proliferating cells

1978 • 18 citations

Hepatotoxicity of 5-azacytidine (NSC-102816) (a clinical and pathologic study).

1973 • 17 citations

The effect of 5-azacytidine on development, nucleic acid and protein metabolism in sea urchin embryos

1970 • 17 citations

Effect of 5-azacytidine on phytohemagglutinin-stimulated horse lymphocytes and cultured mouse L929 cells.

1973 • 17 citations

Combination chemotherapy of L1210 leukemia with 1-beta-D-arabinofuranosylcytosine and 5-azacytidine.

1976 • 17 citations

Formation of 5-azauridine, ribosyl N-formylbiuret, ribosyl biuret, and their 5'-phosphates in Escherichia coli culture from 5-azauracil

1964 • 17 citations

Kinetics of the reduction in viability of cultured L1210 leukemia cells exposed to 5-azacytidine (NSC-102816).

1972 • 16 citations

Effect of 5-azacytidine on dietary and hormone induction of serine dehydratase and tyrosine aminotransferase in rat liver

1972 • 16 citations

Biochemical mechanisms of drug resistance. IX. Metabolic alterations in leukemic mouse cells following 5-aza-2'-deoxycytidine

1969 • 16 citations

The in vivo activity of combinations of 5-azacytidine and cytidine on leukemia L-1210

1968 • 15 citations

Enhanced Stability of Uridine Kinase from Mouse Leukemic Cells Resistant to 5‐Azacytidine

1971 • 15 citations

The Effect of Actinomycin D and 5-Azacytidine on Macromolecular Synthesis in Murine Myeloma Tumor Cells

1972 • 15 citations

Phase I study of twice weekly 5-azacytidine (NSC-102816).

1974 • 15 citations

Virus production induced by various chemical carcinogens in a virogenic hamster cell line transformed by Rous sarcoma virus.

1972 • 15 citations

Altered liver regeneration in partially hepatectomized rats following 5-azacytidine treatment

1969 • 14 citations

Metabolic alterations of liver regeneration. VIII. Enhanced synthesis of DNA in the liver of 5‐azacytidine‐treated rats subjected to partial hepatectomy

1972 • 14 citations

Interruption of pregnancy by 5-azacytidine

1966 • 14 citations

The Mode of Action of 5‐Aza‐2′‐Deoxycytidine in Escherichia coli

1970 • 13 citations

Characteristics of the enzyme uridine-cytidine kinase isolated from a cultured human cell line

1977 • 13 citations

Reduction of Antileukemic and Immunosuppressive Activities of 5-Azacytidine in Mice by Concurrent Treatment with Uridine

1970 • 12 citations

High-frequency induction in vivo of mouse leukemia in AKR strain by 5-azacytidine and 5-iodo-2′-deoxyuridine

1973 • 12 citations

Determination of uridine kinase activity in some human tumours and normal tissues, using 4,5-14-C-6-azauridine as substrate.

1963 • 12 citations

THE CYTOLOGIC AND THE METABOLIC EFFECTS OF A NEW ANTILEUKEMIC ANALOGUE 5-AZACYTIDINE IN NORMAL MICE FOLLOWED AUTORADIOGRAPHICALLY WITH TRITIUM.

1965 • 12 citations

Biochemical mechanisms of drug resistance — XII. Uridine kinases from mouse leukemic cells sensitive and resistant to 5‐azacytidine

1971 • 12 citations

Modulatory effect of cytostatics and chemical carcinogens on liver regeneration (a review).

1974 • 12 citations

Complete inhibition by 5-azacytidine of hormonal induction of tryptophan pyrrolase

1967 • 12 citations

Radioprotective Effect of 5-Azacytidine in AKR Mice

1969 • 11 citations

Inhibitory effect of various cytostatics and cycloheximide on acute experimental pancreatitis in rats.

1977 • 11 citations

5-Azacytidine: Microbiological Assay in Mouse Blood

1969 • 11 citations

A common component involved in the induction of hepatic tyrosine transaminase by hydrocortisone and glucagon

1973 • 11 citations

Pycnotic degeneration of ventricular cells in embryonic brain following transplacental exposure to 5-azacytidine

1972 • 11 citations

Effects of 5-aza-2'-deoxycytidine on DNA synthesis in mouse lymphatic tissues.

1978 • 10 citations

Synthesis of 5-azacytidine-6-13C and -6-14C

1977 • 10 citations

The effect of azapyrimidine nucleosides and deoxynucleosides on the metabolism of thymidine and thymine in cultures of Escherichia coli

1968 • 10 citations

Glucagon-mediated changes in the concentration of rat hepatic tyrosine transaminase: An immunochemical analysis

1974 • 10 citations

Enzymatic synthesis of 5-azacytidine 5′-triphosphate from 5-azacytidine

1976 • 10 citations

Combination therapy with 5-azacytidine (NSC-102816) and methyl-GAG (NSC-32946) in previously treated adults with acute nonlymphocytic leukemia.

1975 • 10 citations

Anabolic transformations of 5-azacytidine in mouse brain

1966 • 9 citations

Enhanced mortality in offsprings of male mice treated with 5-azacytidine prior to mating. Morphological changes in testes.

1976 • 9 citations

Uridine kinase in embryonic rat liver. Modulation of enzyme activity by 5-azacytidine

1973 • 9 citations

Cellular Phosphorylation of 1-β-d-Arabinofuranosylcytosine and 5-Azacytidine with Intact Fibrosarcoma and Leukemic Cells

1975 • 9 citations

In vitro biochemical and cytotoxicity studies with 1-beta-D-arabinofuranosylcytosine and 5-azacytidine in combination.

1975 • 9 citations

Character of the Stimulatory Response of Uridine Kinase in Rat Livers to Cycloheximide Treatment

1975 • 9 citations

The determination of 5‐azapyrimidines and their derivatives in bacterial RNA

1971 • 8 citations

Kinetics of both leukemic and normal cell population reduction following 5-azacytidine.

1975 • 8 citations

Substrate-induced tryptophan pyrrolase in rat liver after 5-azacytidine administration

1969 • 8 citations

Modulation of orotate phosphoribosyltransferase and orotidine 5'-phosphate decarboxylase activities in regenerating rat liver by 5-azacytidine

1974 • 8 citations

Biological characterization of a prolonged antileukemic effect of 5-azacytidine.

1977 • 7 citations

Enhancement of rat liver uridine kinase activity by various metabolic inhibitors

1974 • 7 citations

Azapyrimidine Nucleosides

1975 • 7 citations

Enhanced incorporation of thymidine into DNA in the liver of intact and partially hepatectomized rats pretreated with 5-azacytidine.

1976 • 7 citations

Localization of the labelled 5-azacytidine in cultured mouse embryonic cells

1974 • 7 citations

Characterization of chicken sarcoma viruses induced with chemical carcinogens and mutagens in transformed hamster cells.

1972 • 7 citations

Kinetic studies with 5-azacytidine-5'-triphosphate and DNA-dependent RNA polymerase

1977 • 7 citations

5-Azacytidine: Microbiological Assay in Mouse Blood

1969 • 7 citations

Degradation of rat liver polyribosomes following the administration of 5-azacytidine stability of attached non-ribosomal ribonucleic acids

1973 • 6 citations

Partial reversal of toxic effects of 5-azacytidine by 6-azauridine in normal mice

1965 • 6 citations

Effect of 5-azacytidine and 6-azauridine on the synthesis of DNA in embryonic mouse brain mitotic activity and migration of ventricular cells.

1973 • 6 citations

Inhibition of uridine‐cytidine kinase by 5‐azacytidine 5′‐triphosphate

1976 • 6 citations

Impaired gastric secretion in rats treated with 5-azacytidine.

1974 • 6 citations

Lower gastric secretion and higher incorporation of orotic acid into liver RNA in rats treated with 5-azacytidine and cycloheximide.

1978 • 5 citations

Metabolic alterations of liver regeneration. XI. Modulation of the uptake of orotic acid into ribonucleic acids in regenerating rat liver

1973 • 5 citations

Labeling of Cytoplasmic Liver RNA by [6‐¹⁴C]Orotic and 5‐Fluoro[2‐¹⁴C]orotic Acids

1973 • 5 citations

Combination therapy with 5-azacytidine (NSC-102816) and methyl-GAG (NSC-32946) in previously treated adults with acute nonlymphocytic leukemia.

1975 • 4 citations

Characterization of depressed uridine kinase in rat thymus following 5-azacytidine administration

1974 • 4 citations

Stimulatory Effect of 5-Azacytidine on 7S Antibody Production in Rats

1978 • 4 citations

Enhanced triphosphatase activity of mouse leukemic cells resistant to 5-azacytidine

1968 • 3 citations

Transformation of BHK 21/13 cells by chemical carcinogens and mutagens.

1975 • 3 citations

[On the cytochemistry of polyphosphates in Aspergillus oryzae].

1962 • 2 citations

Activity of uridine kinase in different lines of AKR leukemic mice and its relation to chemotherapy with 5‐azacytidine

1974 • 2 citations

Comparison of the cytostatic action, phosphorylation and deamination of 5-azacytidine and 5,6-dihydro-5-azacytidine in l1210 and hela cells. Abstr.

1977 • 1 citations