Carcinoembryonic Antigen-Specific but Not Antiviral CD4+ T Cell Immunity Is Impaired in Pancreatic Carcinoma Patients

Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity.

1993 • 2,828 citations

Fibrotic disease and the TH1/TH2 paradigm

2004 • 1,623 citations

Prevalence of Regulatory T Cells Is Increased in Peripheral Blood and Tumor Microenvironment of Patients with Pancreas or Breast Adenocarcinoma

2002 • 1,454 citations

The Central Role of CD4+ T Cells in the Antitumor Immune Response

1998 • 1,332 citations

Pancreatic Carcinoma

1992 • 1,175 citations

The Th1/Th2 paradigm

1997 • 1,102 citations

Activation-induced FOXP3 in human T effector cells does not suppress proliferation or cytokine production

2007 • 836 citations

Generation of tissue-specific and promiscuous HLA ligand databases using DNA microarrays and virtual HLA class II matrices

1999 • 747 citations

Th17 Cell Differentiation: The Long and Winding Road

2008 • 675 citations

CD8+ Tumor-Infiltrating Lymphocytes Together with CD4+ Tumor-Infiltrating Lymphocytes and Dendritic Cells Improve the Prognosis of Patients with Pancreatic Adenocarcinoma

2003 • 506 citations

Distinct Role of Antigen-Specific T Helper Type 1 (Th1) and Th2 Cells in Tumor Eradication in Vivo

1999 • 445 citations

Foxp3 Expression in Pancreatic Carcinoma Cells as a Novel Mechanism of Immune Evasion in Cancer

2007 • 338 citations

Disease-associated Bias in T Helper Type 1 (Th1)/Th2 CD4+ T Cell Responses Against MAGE-6 in HLA-DRB10401+ Patients With Renal Cell Carcinoma or Melanoma

2002 • 308 citations

Systemic and local immunosuppression in pancreatic cancer patients.

2001 • 277 citations

T Cells with Low Avidity for a Tissue-Restricted Antigen Routinely Evade Central and Peripheral Tolerance and Cause Autoimmunity

2006 • 266 citations

Inflammatory cells contribute to the generation of an angiogenic phenotype in pancreatic ductal adenocarcinoma

2004 • 251 citations

Peptide binding to HLA-DR1: a peptide with most residues substituted to alanine retains MHC binding.

1990 • 248 citations

Tumor-Associated Transforming Growth Factor-β and Interleukin-10 Contribute to a Systemic Th2 Immune Phenotype in Pancreatic Carcinoma Patients

1999 • 227 citations

Human pancreatic adenocarcinomas express Fas and Fas ligand yet are resistant to Fas-mediated apoptosis.

1998 • 224 citations

Pancreatic cancer microenvironment

2007 • 212 citations

Results and harmonization guidelines from two large-scale international Elispot proficiency panels conducted by the Cancer Vaccine Consortium (CVC/SVI)

2007 • 197 citations

Control of T-Cell–Mediated Immune Response by HLA Class I in Human Pancreatic Carcinoma

2005 • 188 citations

High Frequencies of Functional Tumor-Reactive T Cells in Bone Marrow and Blood of Pancreatic Cancer Patients

2005 • 158 citations

Carcinoembryonic Antigen as a Target for Therapeutic Anticancer Vaccines: A Review

2002 • 150 citations

Elevated Interleukin-6 and G-CSF in Human Pancreatic Cancer Cell Conditioned Medium Suppress Dendritic Cell Differentiation and Activation

2007 • 149 citations

Disease stage variation in CD4+ and CD8+ T-cell reactivity to the receptor tyrosine kinase EphA2 in patients with renal cell carcinoma.

2003 • 143 citations

Coupling Tumor Necrosis Factor-α with αV Integrin Ligands Improves Its Antineoplastic Activity

2004 • 136 citations

Cooperative Induction of a Tolerogenic Dendritic Cell Phenotype by Cytokines Secreted by Pancreatic Carcinoma Cells

2006 • 133 citations

Role of Tumor Endothelium in CD4+CD25+ Regulatory T Cell Infiltration of Human Pancreatic Carcinoma

2007 • 130 citations

Specialization in tolerance: innate CD4+CD25+ versus acquired TR1 and TH3 regulatory T cells.1

2004 • 105 citations

Inhibition of EBV-Induced Lymphoproliferation by CD4+ T Cells Specific for an MHC Class II Promiscuous Epitope

2002 • 88 citations

Expression of Tumor-Associated Differentiation Antigens, MUC1 Glycoforms and CEA, in Human Thymic Epithelial Cells: Implications for Self-Tolerance and Tumor Therapy

2007 • 85 citations

Initiation and maintenance of Th2 cell identity

2008 • 74 citations

Effector T lymphocyte subsets in human pancreatic cancer: detection of CD8+ CD18+ cells and CD8+ CD103+ cells by multi-epitope imaging

1998 • 69 citations

CD4+ T-cell immunity to mutated ras protein in pancreatic and colon cancer patients.

1995 • 63 citations

MUC1-specific CTLs are non-functional within a pancreatic tumor microenvironment.

2001 • 63 citations

Expression of a Natural Tumor Antigen by Thymic Epithelial Cells Impairs the Tumor-Protective CD4+ T-Cell Repertoire

2005 • 57 citations

Identification of an antigenic epitope for helper T lymphocytes from carcinoembryonic antigen.

2002 • 53 citations

CD4(+) T cells from healthy subjects and colon cancer patients recognize a carcinoembryonic antigen-specific immunodominant epitope.

2003 • 53 citations

CD4+ Th2 Cell Recognition of HLA-DR-Restricted Epitopes Derived from CAMEL: A Tumor Antigen Translated in an Alternative Open Reading Frame

2003 • 52 citations

Naturally occurring T-cell response against mutated p21 ras oncoprotein in pancreatic cancer.

2006 • 51 citations

IFN-γ Produced by Human Papilloma Virus-18 E6-Specific CD4+ T Cells Predicts the Clinical Outcome after Surgery in Patients with High-Grade Cervical Lesions

2007 • 48 citations

Demonstration of carcinoembryonic antigen (CEA) expression in normal, chronically inflamed, and malignant pancreatic tissue by immunohistochemistry.

1986 • 43 citations

Immunological Escape Mechanisms in Pancreatic Carcinoma

1999 • 43 citations

Aberrant Gata-3 Expression in Human Pancreatic Cancer

2005 • 40 citations

Detection of peptide‐specific cytotoxic T‐lymphocyte precursors used for specific immunotherapy of pancreatic cancer

2001 • 36 citations

Specific T-cell immunity against Ki-ras peptides in patients with pancreatic and colorectal cancers

2003 • 22 citations

Identification of Novel Subdominant Epitopes on the Carcinoembryonic Antigen Recognized by CD4+ T Cells of Lung Cancer Patients

2006 • 20 citations

Identification of a MHC class-II restricted epitope in carcinoembryonic antigen

2004 • 20 citations

Different Forms of Helper Tolerance to Carcinoembryonic Antigen: Ignorance and Regulation

2007 • 14 citations

Identification and Characterization of a T-Helper Peptide from Carcinoembryonic Antigen

2004 • 14 citations

Endosomal Proteases Influence the Repertoire of MAGE-A3 Epitopes RecognizedIn vivoby CD4+ T Cells

2008 • 14 citations

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