Effects of Chemotherapeutic Agents on the Immune Response. II

Virus interference. I. The interferon

1957 • 3,331 citations

Wegener's Granulomatosis: Prospective Clinical and Therapeutic Experience With 85 Patients for 21 Years

1983 • 2,021 citations

Biological effects of cyclosporin A: A new antilymphocytic agent

1976 • 1,501 citations

Monoclonal Antibodies Defining Distinctive Human T Cell Surface Antigens

1979 • 1,480 citations

Delayed hypersensitivity in vitro: its mediation by cell-free substances formed by lymphoid cell-antigen interaction.

1966 • 1,274 citations

Glucocorticosteroid Therapy: Mechanisms of Action and Clinical Considerations

1976 • 1,035 citations

Corticosteroids and Lymphoid Cells

1972 • 1,030 citations

Corticosteroid‐Mediated Immunoregulation in Man

1982 • 902 citations

Clinical Aspects of Immunology

1976 • 800 citations

Enhanced NK cell activity in mice injected with interferon and interferon inducers

1978 • 735 citations

Marrow Transplantation for Acute Nonlymphoblastic Leukemia in First Remission

1979 • 655 citations

Augmentation of Mouse Natural Killer Cell Activity by Interferon and Interferon Inducers

1979 • 608 citations

The Effect of In Vivo Hydrocortisone on Subpopulations of Human Lymphocytes

1974 • 607 citations

Cyclophosphamide Therapy of Severe Systemic Necrotizing Vasculitis

1979 • 520 citations

Evidence that the L-Asparaginase Activity of Guinea Pig Serum is responsible for its Antilymphoma Effects

1961 • 460 citations

Augmentation of delayed-type hypersensitivity by doses of cyclophosphamide which do not affect antibody responses.

1975 • 434 citations

Cyclosporin A, ein immunsuppressiv wirksamer Peptidmetabolit ausTrichoderma polysporum(L<scp>INK</scp>ex P<scp>ERS</scp>.)Rifai

1976 • 373 citations

Selective depletion of lymphoid tissue by cyclophosphamide.

1972 • 360 citations

Effect of Cortisone on Survival of Skin Homografts in Rabbits

1951 • 312 citations

THE REJECTION OF RENAL HOMOGRAFTS

1960 • 312 citations

Alternate-Day Prednisone

1974 • 298 citations

Differential Effects of Cyclophosphamide on the B and T Cell Compartments of Adult Mice

1973 • 290 citations

Preliminary Observations on the Effect of Human Leukocyte Interferon in Non-Hodgkin's Lymphoma

1978 • 267 citations

Comparative study of in vitro and in vivo drug effects on cell-mediated cytotoxicity.

1976 • 265 citations

Effect of 6-Mercaptopurine on Antibody Production.

1958 • 253 citations

Chemical Suppression of Adaptive Immunity

1967 • 238 citations

Mechanism of Immunosuppression of Progesterone on Maternal Lymphocyte Activation during Pregnancy

1979 • 221 citations

CYCLOSPORIN A FOR THE TREATMENT OF GRAFT-VERSUS-HOST DISEASE IN MAN

1978 • 215 citations

Cyclosporin A - Usefulness, Risks and Mechanism of Action

1982 • 209 citations

Cyclophosphamide in Lupus Nephritis: A Controlled Trial

1971 • 205 citations

Enhancement of Phagocytosis by Interferon-Containing Preparations

1971 • 201 citations

Clinical and Laboratory Investigations on Man: Systemic Administration of Potent Interferon to Man234

1973 • 192 citations

Alternate-Day Prednisone Therapy

1969 • 186 citations

The Effect of Cyclophosphamide on the Ontogeny of the Humoral Immune Response in Chickens

1970 • 183 citations

Effects of Interferon on Antibody Synthesis in Vitro

1974 • 183 citations

Effect of Cyclophosphamide upon the Immune Response in Wegener's Granulomatosis

1971 • 180 citations

Human Renal Transplantation. I, Clinical Experiences with Six Cases of Renal Homotransplantation

1963 • 179 citations

CELLULAR INTERACTIONS IN THE PROLIFERATIVE RESPONSE OF HUMAN T AND B LYMPHOCYTES TO PHYTOMITOGENS AND ALLOGENEIC LYMPHOCYTES

1974 • 177 citations

Activation of Human Natural Killer Cells Cytotoxic for Human Leukemia Cells by Purified Interferon

1979 • 168 citations

The Role of cis-Platinum in Solid-Tumor Therapy

1979 • 166 citations

Cellular immunity after intravenous administration of methylprednisolone.

1974 • 147 citations

Immunosuppressive Effects of Cytosine Arabinoside and Methotrexate in Man

1969 • 144 citations

Prolongation of Homograft Survival in Mice with Single Doses of Cyclophosphamide

1963 • 136 citations

Enhancement of Dinitrochlorobenzene (DNCB) Contact Sensitization by Cyclophosphamide in the Guinea Pig**From the Department of Dermatology, University of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania 19104.

1967 • 133 citations

The effect of immunosuppressive chemotherapy on immune function in patients with malignant disease

1976 • 128 citations

Phase I study of high doses of methotrexate with citrovorum factor in patients with lung cancer

1972 • 126 citations

INHIBITION OF THE REJECTION OF RENAL HOMOGRAFTS IN DOGS BY PURINE ANALOGUES

1961 • 125 citations

Inhibition of the rejection of renal homografts in dogs by purine analogues.

1961 • 125 citations

Interferon Preparations as Modifiers of Immune Responses

1972 • 125 citations

Administration of Human Leukocyte Interferon in Herpes Zoster. I. Safety, Circulating Antiviral Activity, and Host Responses to Infection

1974 • 124 citations

Interferons and their actions

1977 • 122 citations

STUDIES ON CYCLOPHOSPHAMIDE-INDUCED TOLERANCE TO SHEEP ERYTHROCYTES

1967 • 121 citations

Effect of 6-mercaptopurine on inflammation.

1962 • 114 citations

Enhancement by interferon of natural killer cell activity in mice

1979 • 113 citations

Analysis of Mechanism of Immunosuppressive Drugs in Renal Homotransplantation

1964 • 113 citations

Antitumor Effects Of Interferon

1973 • 111 citations

Suppression of Mouse Antibody Producing Spleen Cells by Various Interferon Preparations

1973 • 109 citations

CHANGES IN CONNECTIVE TISSUE REACTION INDUCED BY CORTISONE

1952 • 105 citations

Inhibition of in vitro lymphocyte transformation during chemotherapy in man.

1967 • 104 citations

Oral contraceptives, venous thromboembolic disease, and ABO blood type

1971 • 102 citations

Effect of 17-Hydroxy-11-Dehydrocorticosterone (Compound E) and of ACTH on Arthus Reaction and Antibody Formation in the Rabbit

1950 • 100 citations

Effect of Chemotherapeutic Agents on Natural Cell-Mediated Cytotoxicity in Mice2

1978 • 98 citations

The Effect of 6-Mercaptopurine on Immune Response in Man

1964 • 98 citations

Suppressive Effect of Interferon on the Humoral Immune Response to Sheep Red Blood Cells in Mice

1974 • 95 citations

EFFECTS OF SELECTED CYTOTOXIC AGENTS ON ANTIBODY PRODUCTION IN MAN; A PRELIMINARY REPORT*

1964 • 93 citations

Immunological responses to l-asparaginase

1971 • 90 citations

Mechanisms of Immunosuppression: Effects of Cyclophosphamide on Cellular Immunity

1973 • 88 citations

L-Asparaginase in Treatment of Acute Leukaemia and Lymphosarcoma

1970 • 88 citations

A rabbit with the allotypic phenotype: ala2a3 b4b5b6.

1974 • 87 citations

Adriamycin and daunorubicin: a comparison of antitumor activities and tissue uptake in mice following immunosuppression.

1973 • 84 citations

Treatment of aplastic anemia by bone marrow transplantation in identical twins

1980 • 84 citations

ENHANCEMENT OF ANTIBODY SYNTHESIS BY 6-MERCAPTOPURINE

1966 • 83 citations

Increased primary cell-mediated immunity in culture subsequent to adriamycin or daunorubicin treatment of spleen donor mice.

1977 • 83 citations

L-ASPARAGINASE AND BLASTOGENESIS

1969 • 83 citations

The anti‐inflammatory effect of some immunosuppressive agents

1969 • 82 citations

Enhancement of T Cell Cytotoxic Responses by Purified Human Fibroblast Interferon

1978 • 80 citations

Asparagine synthetase in asparaginase resistant and susceptible mouse lymphomas

1968 • 80 citations

Enhancement of naturally occurring human spontaneous monocyte-mediated cytotoxicity by cis-diamminedichloroplatinum(II).

1980 • 79 citations

Preliminary studies on the effect of 2,6-diaminopurine on transplanted mouse leukemia

1949 • 78 citations

Similarities among factors that render macrophages tumoricidal in lymphokine and interferon preparations.

1978 • 77 citations

Cure of Hematologic Neoplasia with Transplantation of Marrow from Identical Twins

1977 • 74 citations

The immunoglobulin sequence. I. Arrest by 6-mercaptopurine and restitution by antibody, antigen or splenectomy.

1965 • 71 citations

Effect of Synthetic Progestational Agents on Allograft Rejection and Circulating Antibody Production

1965 • 71 citations

IMMUNOSUPPRESSIVE AGENTS

1965 • 71 citations

STUDIES ON THE ANTI-INFLAMMATORY ACTION OF 6-MERCAPTOPURINE

1968 • 68 citations

Cyclophosphamide suppression of established cell-mediated immunity. Quantitative vs. qualitative changes in lymphocyte populations.

1975 • 68 citations

The relative reactivities of deoxyribonucleotides and of the bases of DNA towards alkylating agents

1957 • 68 citations

IMMUNOSUPPRESSIVE EFFECTS OF AN INTERFERON PREPARATION IN VIVO

1974 • 67 citations

THE ROLE OF ADRENOCORTICAL STEROIDS IN REVERSING ESTABLISHED HOMOGRAFT REJECTION.

1964 • 66 citations

The effect of cyclophosphamide and other drugs on the incidence of pulmonary metastases in mice.

1977 • 66 citations

In vitro and in vivo cytotoxicity of adriamycin and daunomycin for murine macrophages.

1977 • 65 citations

Inhibition of the primary immune response in man by anti-metabolites.

1965 • 65 citations

L-Asparaginase and Human Malignant Disease

1971 • 62 citations

IMMUNOSUPPRESSION WITH MEDROXYPROGESTERONE ACETATE

1968 • 61 citations

Role of Host Defense Mechanisms in the Antitumor Activity of Adriamycin and Daunomycin in Mice&lt;xref ref-type="fn" rid="fn2"&gt;2&lt;/xref&gt;

1979 • 61 citations

STUDIES ON THE ADJUVANT ACTION OF BACTERIAL ENDOTOXINS ON ANTIBODY FORMATION. V. THE INFLUENCE OF ENDOTOXIN AND 5-FLUORO-2-DEOXYURIDINE ON THE PRIMARY ANTIBODY RESPONSE OF THE BALB MOUSE TO A PURIFIED PROTEIN ANTIGEN.

1963 • 61 citations

Immunotoxicity Assessment: Screening and Function Studies

1980 • 60 citations

Double‐blind study of cyclophosphamide in rheumatoid arthritis

1973 • 58 citations

Immunosuppression by L-Asparaginase

1969 • 53 citations

Heterocyclic substituted ureas. I. Immunosuppression and virus inhibition by benzimidazolylureas

1969 • 53 citations

Immunosuppression by 5-fluorouracil

1970 • 52 citations

Renal Transplantation: Theory and Practice

1973 • 51 citations

Differential Effects of Immunosuppressants on Lymphocyte Function

1973 • 51 citations

Intermittent Steroid Therapy

1968 • 51 citations

A COMPARISON OF THE EFFECTS OF SELECTED CYTOTOXIC AGENTS ON ALLOGENEIC SKIN GRAFT SURVIVAL IN RATS.

1965 • 50 citations

A characterization of the immunosuppressive activity of adriamycin and daunomycin on humoral antibody production and tumor allograft rejection.

1976 • 46 citations

Comparative study of cyclophosphamide, 6-mercaptopurine, azathiopurine and methotrexate. Relative effects on the humoral and the cellular immune response in the mouse.

1976 • 46 citations

Cyclophosphamide and lymphocyte subpopulations in Wegener's granulomatosis

1974 • 44 citations

Destruction and Regeneration of Lymphocyte Populations in the Mouse Spleen after Cyclophosphamide Treatment

1974 • 44 citations

The effect of mustard gas (dichlorethyl-sulphid) on antibody formation

1921 • 44 citations

Cis-Dichlorodiammineplatinum [II]: Inhibition of Nucleic Acid Synthesis in Lymphocytes Stimulated with Phytohemagglutinin

1971 • 43 citations

Antigen-antibody complexes generate Lyt 1 inducers of suppressor cells.

1980 • 41 citations

Effect of azathioprine and cytosine arabinoside on humoral and cellular immunity in vitro.

1973 • 40 citations

Effects of Interferon on Leukaemia Virus Activation in Graft versus Host Disease

1973 • 40 citations

Induction in vitro of reversible immunosuppression and inhibition of B cell receptor regeneration by defined metabolites of cyclophosphamide

1979 • 39 citations

Comparison of the immunosuppressive effects of asparaginases from Escherichia coli and Vibrio succinogenes.

1980 • 39 citations

Effect of imidazole-4-carboxamide, 5-(3,3-dimethyl-1-triazeno) on immunity in patients with malignant melanoma.

1974 • 39 citations

Immunosuppression by pyrimidine nucleoside analogs

1966 • 39 citations

The effects of ACTH and cortisone on antibodies in human beings.

1951 • 39 citations

Immunologic, toxicologic and marrow transplantation studies in dogs given dimethyl myleran.

1974 • 36 citations

Modulation of the immune response by by chemotherapy

1981 • 36 citations

Rabbit Immunoglobulin Light Chains: Correlation of Variable Region Sequences with Allotypic Markers

1973 • 36 citations

Selective depletion of Ig‐bearing lymphocytes by cyclophosphamide in rheumatoid arthritis and systemic lupus erythematosu guidelines for dosage

1974 • 35 citations

Effect of cyclosporin A on human lymphocyte responses in vitro. V. Analysis of responding T lymphocyte subpopulations in primary MLR with monoclonal antibodies.

1983 • 35 citations

Time-dependence and selectivity of immunosuppressive agents.

1979 • 34 citations

PROGESTERONE, 20α-DIHYDROPROGESTERONE AND 20β-DIHYDROPROGESTERONE IN MOTHER AND CHILD AT BIRTH

1975 • 33 citations

Immunological mechanisms in the maintenance of pregnancy.

1980 • 32 citations

Studies on the Adjuvant Action of Bacterial Endotoxins on Antibody Formation

1963 • 32 citations

IMMUNOSUPPRESSION BY L-ASPARAGINASE AND RELATED ENZYMES

1971 • 31 citations

The Immunoglobulin Sequence

1965 • 31 citations

The immunodepressive activity of Escherichia coli L-asparaginase in some transplantation systems.

1970 • 30 citations

APPLICATION OF IMMUNOCOMPETENCE ASSAYS FOR DEFINING IMMUNOSUPPRESSION

1979 • 29 citations

IMMUNOSUPPRESSIVE ACTION OF L-ASPARAGINASE

1969 • 29 citations

Renal Transplantation: Theory and Practice

1982 • 28 citations

Antibody Production in Guinea Pigs Receiving 6-Mercaptopurine.

1961 • 27 citations

PROLONGED ACCEPTANCE OF A CANINE RENAL ALLOGRAFT ACHIEVED WITH PREDNISOLONE

1965 • 27 citations

Virologic and immunologic properties and response to daunomycin and adriamycin of a non-regressing mouse tumor derived from MSV-induced sarcoma.

1974 • 27 citations

L-ASPARAGINASE AND BLASTOGENESIS

1969 • 27 citations

The Production of Tolerance to Human Erythrocytes in the Rat with Cytosine Arabinoside or Cyclophosphamide

1969 • 26 citations

Immunosuppressive Agents and the Cellular Kinetics of the Immune Response

1967 • 26 citations

THE IMMUNOSUPPRESSIVE ACTIVITY OF ARA-CYTIDINE

1968 • 25 citations

Immunosuppressive Agents

1974 • 25 citations

The Inhibition of Hemagglutinin Formation in Mice by Purine and Pyrimidine Analogues

1962 • 25 citations

IMMUNODEPRESSANT ACTIVITY AND 6-MERCAPTOPURINE LEVELS AFTER ADMINISTRATION OF 6-MERCAPTOPURINE AND AZATHIOPRINE

1973 • 24 citations

Cell-mediated immunity and blocking factor in ovarian carcinoma.

1976 • 24 citations

The effects of bleomycin on immunocompetence in man.

1975 • 23 citations

Interference of daunomycin and adriamycin on the growth and aggression of murine sarcoma virus (Moloney) tumors in mice.

1971 • 23 citations

PROLONGATION OF CANINE RENAL HOMOGRAFT SURVIVAL BY ANTIMETABOLITES

1963 • 23 citations

Effect of adriamycin and high-dose methotrexate chemotherapy onin vivo andin vitro cell-mediated immunity in cancer patients

1978 • 23 citations

Comparison of the L-asparaginases from Escherichia coli and Erwinia carotovora as immunosuppressants.

1974 • 22 citations

Effect of chemotherapy and immunotherapy on tumor-specific immunity in melanoma.

1977 • 22 citations

Marked Immunosuppression With Minimal Myelosuppression by Bleomycin In Vitro

1973 • 22 citations

Specificity of immunosuppression by antimetabolites.

1966 • 21 citations

Effect of fluoropyrimidines on delayed cutaneous hypersensitivity.

1965 • 21 citations

EFFECTS OF SEVERAL TUMOR-INHIBITORY ANTIBIOTICS ON IMMUNOLOGICAL RESPONSES

1969 • 21 citations

Inhibitory effect of L-asparaginase in lymphocyte transformation induced by phytohemagglutinin.

1970 • 19 citations

TESTS FOR THE DETERMINATION OF THE EFFECT OF ANTIMITOTIC PRODUCTS ON IMMUNE REACTIONS.

1964 • 18 citations

Failure of bleomycin to affect humoral or cell-mediated immunity in the mouse.

1974 • 18 citations

The imidazoles as immunosuppressive agents

1981 • 18 citations

Studies on Immune Suppressive Drugs.

1967 • 17 citations

Suppression of spleen lymphocyte mitogenesis in mice injected with platinum compounds

1979 • 17 citations

Inhibition of Immune Processes by ‘Melphalan’

1964 • 17 citations

THE IMMUNOSUPPRESSIVE ACTIVITY OF ARA-CYTIDINE (CYTARABINE)

1969 • 16 citations

Alteration of antibody synthesis in the rat by cytosine arabinoside.

1969 • 16 citations

SUPPRESSION OF THE HOMOGRAFT RESPONSE BY PRETREATMENT WITH ANTITUMOR AGENTS

1963 • 16 citations

The Effect of Pteroylglutamic Acid on Some Immune Responses of Chicks

1950 • 15 citations

An in vivo evaluation of the immunosuppressive action of bleomycin.

1972 • 15 citations

Reversal by L-Glutamine of the Inhibition of Lymphocyte Mitosis Caused by E. coli Asparaginase

1970 • 15 citations

Studies on the Inhibition of Antibody Formation in the Guinea-Pig with Cyclophosphamide, Azathiopurine, 5-Fluorouracil and Urethane

1966 • 13 citations

Lack of immunosuppressive effect of bleomycin on the primary response of mice to sheep red blood cells.

1971 • 12 citations

Renal transplantation under cyclophosphamide.

1972 • 11 citations

Heterogeneity of the Interaction of Anticancer Agents with the Immune System and Its Possible Relevance in Chemoimmunotherapy

1980 • 10 citations

Inhibitory effect of interferon on DNA and RNA synthesis in murine spleen cells stimulated by lectins.

1976 • 10 citations

Enhanced Suppression of Experimental Allergic Encephalomyelitis by Combination Chemotherapy with Duazomycin-A and 6-Mercaptopurine

1969 • 9 citations

L-ASPARAGINASE AND LYMPHOCYTE BLASTOGENESIS

1971 • 9 citations

The effect of 6-mercaptopurine on immune responsiveness of the dog.

1962 • 7 citations

Effect of Dimethylmyleran on Cell-Mediated Immunity to a Tumor Allograft2

1975 • 7 citations

Immunosuppressive effects of sulfato-trans-(-)-1,2-diaminocyclohexaneplatinum(II).

1979 • 6 citations

P.H.A. RESPONSE AND CYTOTOXIC DRUGS

1972 • 6 citations

Increased development of PHA-stimulated murine colonies in vitro subsequent to Adriamycin or daunorubicin treatment of spleen donor mice

1979 • 6 citations

L-ASPARAGINASE AND METASTASIS

1970 • 6 citations

Antitumor Effects of Doxorubicin Against a Virally-Induced Rat Osteosarcoma with Minimal Immunosuppression

1980 • 6 citations

Effect of 1-(2-chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea adjuvant therapy on the immune response of patients with malignant melanoma.

1979 • 4 citations

Daunomycin and skin allografts survival in mice

1970 • 2 citations

Deleted Work

1955 • 0 citations