Glucocorticosteroid Therapy: Mechanisms of Action and Clinical Considerations

Corticosteroids and Lymphoid Cells

1972 • 1,030 citations

LEUKOKINETIC STUDIES. IV. THE TOTAL BLOOD, CIRCULATING AND MARGINAL GRANULOCYTE POOLS AND THE GRANULOCYTE TURNOVER RATE IN NORMAL SUBJECTS*

1961 • 626 citations

The Effect of In Vivo Hydrocortisone on Subpopulations of Human Lymphocytes

1974 • 607 citations

Tissue effects of glucocorticoids

1972 • 503 citations

The recirculation of lymphocytes from blood to lymph in the rat

1959 • 500 citations

Inhibition of Granulocyte Adherence by Ethanol, Prednisone, and Aspirin, Measured with an Assay System

1974 • 496 citations

Circulating T and B lymphocytes of the mouse

1973 • 417 citations

Mechanism of action of glucocorticoids

1974 • 391 citations

Mechanisms of corticosteroid action on lymphocyte subpopulations. I. Redistribution of circulating T and b lymphocytes to the bone marrow.

1975 • 345 citations

Studies on an Intermittent Corticosteroid Dosage Regimen

1963 • 342 citations

Tuberculosis complicating neoplastic disease.A review of 201 cases

1974 • 339 citations

Effects of Corticosteroids on Immunity in Man I. DECREASED SERUM IgG CONCENTRATION CAUSED BY 3 OR 5 DAYS OF HIGH DOSES OF METHYLPREDNISOLONE

1973 • 331 citations

STUDIES ON LYSOSOMES

1962 • 317 citations

Comparison of agents producing a neutrophilic leukocytosis in man. Hydrocortisone, prednisone, endotoxin, and etiocholanolone.

1975 • 310 citations

Human lymphocyte subpopulations. Effect of corticosteroids.

1974 • 307 citations

Alternate-Day Prednisone

1974 • 298 citations

Leukokinetic studies

1968 • 296 citations

Mechanisms of Action of Steroid Hormones

1971 • 293 citations

Incidence of infection in systemic lupus erythematosus

1974 • 275 citations

Effects of Corticosteroid Therapy on Human Monocyte Function

1975 • 268 citations

Cellular hypersensitivity and immunity. Inhibition of macrophage migration and the lymphocyte mediators.

1972 • 260 citations

In Vitro Approaches to the Mechanism of Cell-Mediated Immune Reactions

1971 • 258 citations

THE EFFECT OF GLUCOCORTICOSTEROIDS ON THE KINETICS OF MONONUCLEAR PHAGOCYTES

1970 • 252 citations

Effects of Corticosteroids on Human Monocyte Function

1974 • 245 citations

The Immunological Activities of Lymphocytes

2015 • 241 citations

THE CHEMOSUPPRESSION OF CHEMOTAXIS

1966 • 240 citations

GLUCOCORTICOID SUPPRESSION OF MACROPHAGE MIGRATION INHIBITORY FACTOR

1973 • 235 citations

The effect of Hydrocortisone on the kinetics of normal human lymphocytes

1975 • 234 citations

RECIRCULATION OF LYMPHOCYTES*

1964 • 233 citations

Quantitative Studies of Phagocytosis by Polymorphonuclear Leukocytes: Use of Emulsions to Measure the Initial Rate of Phagocytosis

1972 • 230 citations

EFFECT OF GLYCOSIDASES ON THE FATE OF TRANSFUSED LYMPHOCYTES

1964 • 212 citations

Adrenal glucocorticoids after twenty years

1970 • 209 citations

Alternate-Day Prednisone Therapy

1969 • 186 citations

Antigen-Induced Proliferation of Guinea Pig Lymphocytes in Vitro: Obligatory Role of Macrophages in the Recognition of Antigen by Immune T-Lymphocytes

1973 • 185 citations

Inhibition of human leukocyte mitosis by prednisolone in vitro.

1961 • 181 citations

Alternate-day prednisone therapy and human lymphocyte subpopulations.

1975 • 179 citations

The effect of an NADH oxidase inhibitor (hydrocortisone) on polymorphonuclear leukocyte bactericidal activity

1970 • 178 citations

Thymus-Derived Lymphocytes Sequestered in the Bone Marrow of Hydrocortisone-Treated Mice

1972 • 171 citations

Hydrocortisne resistance of graft vs host activity in mouse thymus, spleen and bone marrow.

1970 • 165 citations

The traffic of lymphocytes.

1969 • 153 citations

Cellular immunity after intravenous administration of methylprednisolone.

1974 • 147 citations

Corticosteroids and Infectious Diseases

1973 • 146 citations

THE EFFECT OF ADRENAL GLUCOCORTICOSTEROIDS UPON THE CELLULAR COMPOSITION OF INFLAMMATORY EXUDATES.

1964 • 137 citations

THE EFFECT OF GLUCOCORTICOSTEROIDS ON THE PROLIFERATION AND KINETICS OF PROMONOCYTES AND MONOCYTES OF THE BONE MARROW

1973 • 136 citations

Staphylococcal Bacteremia and Altered Host Resistance

1968 • 135 citations

Clinical and laboratory aspects of listeria monocytogenes infections with a report of ten cases

1968 • 132 citations

Lymphocytes: Circulation Altered by Trypsin

1968 • 131 citations

Lymphotoxin formation by lymphocytes and muscle in polymyositis

1972 • 127 citations

Bone Marrow and Spleen: Dissociation of Immunologic Properties by Cortisone

1970 • 120 citations

Benefit from Alternate-Day Prednisone in Myasthenia Gravis

1972 • 119 citations

Bacterial infection in renal homotransplant recipients

1972 • 113 citations

Effects of Corticosteroids and Splenectomy on the Immune Clearance and Destruction of Erythrocytes

1973 • 113 citations

Corticosteroids and lymphoid cells in vitro. I. Hydrocortisone lysis of human, guinea pig, and mouse thymus cells.

1971 • 113 citations

The role of adrenocortical steroids in infection, immunity and hypersensitivity.

1956 • 112 citations

Lymphocytes and the Immune Response

1971 • 107 citations

Plasma Kinins and Cortisol: A Possible Explanation of the Anti-Inflammatory Action of Cortisol

1966 • 106 citations

CHANGES IN CONNECTIVE TISSUE REACTION INDUCED BY CORTISONE

1952 • 105 citations

Corticosteroid Administration and Localized Leukocyte Mobilization in Man

1972 • 105 citations

Interaction between “sensitized lymphocytes” and antigen in vitro

1970 • 102 citations

Lymphocyte In Vitro Cytotoxicity: Correlation of Derepression with Release of Lymphotoxin from Human Lymphocytes

1969 • 100 citations

Human bone marrow lymphocytes. I. Distribution of lymphocyte subpopulations in the bone marrow of normal individuals.

1975 • 99 citations

Steroid Aerosols in Asthma: An Assessment of Betamethasone Valerate and a 12-month Study of Patients on Maintenance Treatment

1974 • 94 citations

Site of Action of Cortisol in Cellular Immunity

1973 • 94 citations

Immunosuppressive Effects of Glucocorticosteroids: Differential Effects of Acute vs Chronic Administration on Cell-Mediated Immunity

1975 • 86 citations

STUDIES ON THE PATHOGENESIS OF ACUTE INFLAMMATION

1955 • 83 citations

THE NATURE AND THE SPECIFICITY OF MONONUCLEAR CELLS IN EXPERIMENTAL AUTOIMMUNE INFLAMMATIONS AND THE MECHANISMS LEADING TO THEIR ACCUMULATION

1971 • 82 citations

Clinical Considerations in the Use of Corticosteroids

1966 • 82 citations

Clinical pharmacology of the anti‐inflammatory steroids

1961 • 81 citations

Corticosteroids and infections.

1958 • 79 citations

The Effect of Massive Doses of Cortisone on the Peripheral Blood and Bone Marrow of the Mouse

1951 • 74 citations

Depression of lymphocyte responses after surgical trauma.

1973 • 73 citations

The Inhibitory Effect of Hydrocortisone on Lysis of Homologous Cells by Lymphocytes in Vitro

1962 • 71 citations

Effect of Cortisone Therapy on Serum Complement Components

1973 • 71 citations

Anti-Immunologic and Anti-Inflammatory Effects of Steroid Therapy

1973 • 70 citations

Complement-independent Clearance of IgG-sensitized Erythrocytes: Inhibition by Cortisone

1974 • 69 citations

A unique influence of cortisone on the transit of specific macromolecules across vascular walls in immune complex disease.

1968 • 65 citations

The effect of hydrocortisone on the incorporation of tritiated thymidine by human blood lymphocytes cultured with phytohaemagglutinin and pokeweed mitogen.

1973 • 64 citations

ADRENAL STEROIDS AND INFECTION: THE EFFECT OF CORTISONE ADMINISTRATION ON POLYMORPHONUCLEAR LEUKOCYTIC FUNCTIONS AND ON SERUM OPSONINS AND BACTERICIDINS*

1961 • 62 citations

Studies on steroid fever II. Pyrogenic and anti-pyrogenic activity in vitro of some endogenous steroids of man

1970 • 60 citations

Effects of Steroid Hormones on Human Polymorphonuclear Leukocyte Lysosomes

1974 • 53 citations

Cellular Hypersensitivity and Immunity

2015 • 53 citations

Disappearance rates and immunosuppression of intermittent intravenously administered prednisolone in rabbits and human beings.

1970 • 53 citations

Corticosteroids and immunoglobulin synthesis.

1975 • 52 citations

COMPARATIVE EFFECTS OF CORTICOSTEROIDS ON HOST RESISTANCE TO INFECTION IN RELATION TO CHEMICAL STRUCTURE

1967 • 50 citations

Eosinopenic Response to Cortisone and A.C.T.H. in Normal Subjects

1951 • 47 citations

AUTORADIOGRAPHIC STUDIES OF EOSINOPHIL KINETICS: EFFECTS OF CORTISOL*

1969 • 46 citations

The in vitro effect of hydrocortisone on the uptake and intracellular digestion of particulate matter by macrophages in culture.

1972 • 45 citations

Effect of hydrocortisone on the reactivity of thymus and spleen cells of mice to in vitro stimulation.

1972 • 44 citations

Alternate-Day Steroid Therapy in Lupus Nephritis

1970 • 41 citations

THE IMMUNE RESPONSE TO FOREIGN RED BLOOD CELLS AND THE PARTICIPATION OF SHORT-LIVED LYMPHOCYTES

1967 • 41 citations

Leukocyte chemotaxis in vivo. II. Analysis of the selective inhibition of neutrophil or mononuclear cell accumulation.

1974 • 41 citations

Inhibitory effects of hydrocortisone upon the phytohemagglutinin-induced RNA-synthesis in human lymphocytes

1968 • 38 citations

Atrophy of the Thymus in Normal and Hypophysectomized Rats Following Administration of Cortin

1938 • 38 citations

MIGRATION OF SMALL LYMPHOCYTES IN ADULT MICE DEMONSTRATED BY PARABIOSIS

1974 • 37 citations

Studies of Lymphocyte Kinetics in Man

1967 • 35 citations

The Influence of Cortisone on the Passive Transfer of Tuberculin Hypersensitivity in the Guinea Pig

1952 • 32 citations

Alternate-day single-dose prednisone therapy: A method of reducing steroid toxicity

1972 • 31 citations

The effect of hydrocortisone on lymphocyte-mediated cytolysis

1973 • 29 citations

Thymic involution and recovery: immune responsiveness and immunoglobulins after neonatal prednisolone in rats.

1966 • 29 citations

Mechanism of cortisol inhibition of adoptive transfer of tuberculin sensitivity.

1973 • 29 citations

The effect of alternate-day prednisone on the white blood count in children with chronic asthma

1973 • 26 citations

Suppressed reduction of nitroblue tetrazolium by polymorphonuclear neutrophils from patients receiving steroids

1971 • 26 citations

The cellular basis of the mechanism of action of cortisone acetate on contact sensitivity to oxazolone in the mouse.

1972 • 24 citations

Cytotoxin(s) produced by human lymphocytes: Inhibition by anti-inflammatory steroids and anti-malarial drugs

1971 • 22 citations

The Effect of Cortisone and Adrenocorticotropic Hormone on Passively Transferred Delayed Hypersensitivity to 2,4-Dinitrochlorobenzene in Guinea Pigs

1954 • 20 citations

Bacteriuria in rheumatoid arthritis.

1973 • 19 citations

STIMULATION OF RAT LYMPHOCYTE PROLIFERATION BY HYDROCORTISONE DURING THE INDUCTION OF CELL-MEDIATED IMMUNITY IN VITRO

1974 • 18 citations

LYSOSOMAL MECHANISMS IN THE INFLAMMATORY PROCESS

1974 • 17 citations

Effect of L-asparaginase and hydrocortisone on human lymphocyte transformation and production of a mononuclear leucocyte chemotactic factor in vitro.

1974 • 17 citations

Alternate-Day Prednisone Therapy for Pemphigus Vulgaris

1971 • 16 citations

Steroid Therapy of Allergic Diseases

1973 • 14 citations

Glucocorticoid-kinin antagonism in the rat

1966 • 13 citations

Successful initiation of alternate-day prednisone in chronic steroid-dependent asthmatic patients

1972 • 12 citations

Cellular basis of cortisone-induced host susceptibility to tuberculosis.

1969 • 12 citations

THE EXPERIMENTAL APPROACH TO THE STUDY OF INFLAMMATION

1974 • 11 citations

Effects of Hydrocortisone on Lymphocytes Stimulated by Phytohaemagglutinin and Pokeweed Mitogen

1972 • 10 citations

Effect of hydrocortisone on in vitro cellular immunity to viruses in man

1975 • 6 citations

Lack of Interaction between Glucocorticoids and the Kallikrein-Kinin System

1974 • 4 citations