Inflammation and Pregnancy

Epidemiology and causes of preterm birth

2008 • 7,083 citations

Matrix Metalloproteinases: A Review

1993 • 2,998 citations

Circulating angiogenic factors and the risk of preeclampsia*

2004 • 2,591 citations

Intrauterine Infection and Preterm Delivery

2000 • 2,501 citations

Human Chemokines: An Update

1997 • 2,235 citations

Signaling to NF-κB by Toll-like receptors

2007 • 2,120 citations

The Complex Role of Estrogens in Inflammation

2007 • 1,668 citations

Urocortin, a mammalian neuropeptide related to fish urotensin I and to corticotropin-releasing factor

1995 • 1,469 citations

Inferences, questions and possibilities in Toll-like receptor signalling

2004 • 1,458 citations

NF-κB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1α

2008 • 1,436 citations

The Extra Domain A of Fibronectin Activates Toll-like Receptor 4

2001 • 1,200 citations

Protease‐activated receptors in hemostasis, thrombosis and vascular biology

2005 • 971 citations

Endocrine and Paracrine Regulation of Birth at Term and Preterm*

2000 • 842 citations

The matrix component biglycan is proinflammatory and signals through Toll-like receptors 4 and 2 in macrophages

2005 • 794 citations

Directing Transition from Innate to Acquired Immunity: Defining a Role for IL-6

2005 • 753 citations

Inflammation in preterm and term labour and delivery

2006 • 681 citations

Leukocyte density and pro-inflammatory cytokine expression in human fetal membranes, decidua, cervix and myometrium before and during labour at term

2003 • 670 citations

Role of Tissue Factor in Hemostasis, Thrombosis, and Vascular Development

2004 • 616 citations

HMGB1 release induced by liver ischemia involves Toll-like receptor 4–dependent reactive oxygen species production and calcium-mediated signaling

2007 • 589 citations

Leukocytes infiltrate the myometrium during human parturition: further evidence that labour is an inflammatory process

1999 • 498 citations

Deficiency in catechol-O-methyltransferase and 2-methoxyoestradiol is associated with pre-eclampsia

2008 • 365 citations

Recognition of Hyaluronan Released in Sterile Injury Involves a Unique Receptor Complex Dependent on Toll-like Receptor 4, CD44, and MD-2

2007 • 362 citations

Immunolocalization of Proinflammatory Cytokines in Myometrium, Cervix, and Fetal Membranes During Human Parturition at Term1

2002 • 358 citations

A New Model for Inflammation-Induced Preterm Birth

2003 • 342 citations

Risk factors for preterm premature rupture of fetal membranes: A multicenter case-control study

1990 • 341 citations

Clinical significance of intra-amniotic inflammation in patients with preterm premature rupture of membranes

2004 • 318 citations

The Physiology of Fetal Membrane Rupture: Insight Gained from the Determination of Physical Properties

2006 • 305 citations

Human labour is associated with nuclear factor-kappaB activity which mediates cyclo-oxygenase-2 expression and is involved with the 'functional progesterone withdrawal'

2001 • 304 citations

A polymorphism in the promoter region of TNF and bacterial vaginosis: preliminary evidence of gene-environment interaction in the etiology of spontaneous preterm birth

2004 • 300 citations

Human cervical ripening, an inflammatory process mediated by cytokines

2000 • 276 citations

Estrogen, A Double-Edged Sword: Modulation of TH1- and TH2-Mediated Inflammations by Differential Regulation of TH1 / TH2 Cytokine Production

2004 • 257 citations

Recombinant Vascular Endothelial Growth Factor 121 Attenuates Hypertension and Improves Kidney Damage in a Rat Model of Preeclampsia

2007 • 253 citations

Expression of Matrix Metalloproteinase (MMP)-2 and MMP-9 in Human Placenta and Fetal Membranes in Relation to Preterm and Term Labor

2002 • 229 citations

Human spontaneous labor without histologic chorioamnionitis is characterized by an acute inflammation gene expression signature

2006 • 220 citations

Association between the Asp299Gly Polymorphisms in the Toll-like Receptor 4 and Premature Births in the Finnish Population

2002 • 208 citations

Roles of activin in tissue repair, fibrosis, and inflammatory disease

2006 • 207 citations

Progesterone withdrawal: key to parturition

2007 • 192 citations

Cytokine Networks and the Regulation of Uterine Function in Pregnancy and Parturition

2008 • 168 citations

Expression of cyclo-oxygenase types-1 and -2 in human myometrium throughout pregnancy

1999 • 163 citations

Corticotropin-Releasing Hormone Augments Proinflammatory Cytokine Production from Macrophages In Vitro and in Lipopolysaccharide-Induced Endotoxin Shock in Mice

2002 • 162 citations

Functionally significant SNP MMP8 promoter haplotypes and preterm premature rupture of membranes (PPROM)

2004 • 142 citations

The role of thrombin in preterm parturition

2001 • 141 citations

Neutrophil elastase and secretory leukocyte protease inhibitor in prelabor rupture of membranes, parturition and intra-amniotic infection

2002 • 136 citations

Expression and secretion of activin A: possible physiological and clinical implications

2001 • 135 citations

Oxytocin decreases carrageenan induced inflammation in rats

2001 • 130 citations

Innate Immune Defences in the Human Uterus during Pregnancy

2007 • 128 citations

Interleukin‐6 Up‐Regulates the Oxytocin Receptor in Cultured Uterine Smooth Muscle Cells

2001 • 114 citations

Thrombin-enhanced matrix metalloproteinase-1 expression: a mechanism linking placental abruption with premature rupture of the membranes

2002 • 114 citations

Anti-inflammatory neuropeptides: A new class of endogenous immunoregulatory agents

2008 • 109 citations

Activation of coagulation system in preterm labor and preterm premature rupture of membranes

2002 • 102 citations

Leukocyte Density and Proinflammatory Mediator Expression in Regional Human Fetal Membranes and Decidua Before and During Labot at Term

2006 • 100 citations

Regulation of production of activin A in human marrow stromal cells and monocytes.

1992 • 98 citations

Mechanisms of Abruption-Induced Premature Rupture of the Fetal Membranes

2005 • 96 citations

Plasma levels of thrombin-antithrombin complexes predict preterm premature rupture of the fetal membranes

2001 • 95 citations

Plasma levels of thrombin-antithrombin complexes predict preterm premature rupture of the fetal membranes

2001 • 95 citations

Physiological roles of urocortins, human homologues of fish urotensin I, and their receptors

2004 • 95 citations

Inflammatory response in preeclampsia

2007 • 91 citations

Expression of Toll-like receptors in the human decidua.

2007 • 91 citations

Mechanisms of abruption-induced premature rupture of the fetal membranes: Thrombin enhanced decidual matrix metalloproteinase-3 (stromelysin-1) expression

2004 • 90 citations

Differential cyclooxygenase-1 and -2 gene expression in human myometria from preterm and term deliveries.

1994 • 90 citations

The Corticotropin-Releasing Factor (CRF) Family of Neuropeptides in Inflammation: Potential Therapeutic Applications

2005 • 87 citations

Urocortin 1 and Urocortin 2 induce macrophage apoptosis via CRFR₂

2005 • 83 citations

Activin A Stimulates Type IV Collagenase (Matrix Metalloproteinase-2) Production in Mouse Peritoneal Macrophages

2000 • 81 citations

Intrauterine infection and the effects of inflammatory mediators on prostaglandin production by myometrial cells from pregnant women

1996 • 80 citations

Glucocorticoids Induce Cytosolic Phospholipase A2 and Prostaglandin H Synthase Type 2 But Not Microsomal Prostaglandin E Synthase (PGES) and Cytosolic PGES Expression in Cultured Primary Human Amnion Cells

2003 • 77 citations

Can medroxyprogesterone acetate alter Toll-like receptor expression in a mouse model of intrauterine inflammation?

2005 • 77 citations

Secretion of tissue inhibitors of matrix metalloproteinases by human fetal membranes, decidua and placenta at parturition

1999 • 77 citations

Toll-like Receptor 2 Polymorphism Is Associated With Preterm Birth

2007 • 75 citations

Serum Growth Factors and Proinflammatory Cytokines Are Potent Inducers of Activin Expression in Cultured Fibroblasts and Keratinocytes

1996 • 75 citations

Inhibin and Activin Modulate Human Monocyte Chemotaxis and Human Lymphocyte Interferon-γ Production*

1991 • 74 citations

Therapeutic effect of urocortin on collagen‐induced arthritis by down‐regulation of inflammatory and Th1 responses and induction of regulatory T cells

2007 • 73 citations

Progestin-Inflammatory Cytokine Interactions Affect Matrix Metalloproteinase-1 and -3 Expression in Term Decidual Cells: Implications for Treatment of Chorioamnionitis-Induced Preterm Delivery

2007 • 72 citations

Expression, localization and function of prostaglandin receptors in myometrium

2003 • 72 citations

Corticosteroid-independent inhibition of tumor necrosis factor production by the neuropeptide urocortin

1998 • 64 citations

Role of progesterone and progestin therapy in threatened abortion and preterm labour

2007 • 62 citations

Regulation of the Human Oxytocin Receptor by Nuclear Factor-κB and CCAAT/Enhancer-Binding Protein-β

2006 • 57 citations

Activin A regulates growth and acute phase proteins in the human liver cell line, HepG2

1999 • 56 citations

Progesterone facilitates Implantation of Xenogenic Cultured Cells in Hamster Uterus

1972 • 55 citations

Role of activin A in murine mast cells: modulation of cell growth, differentiation, and migration

2003 • 55 citations

CONTRASTING EFFECTS OF INFLAMMATROY CYTOKINES AND GLUCOCORTICOIDS ON THE PRODUCTION OF ACTIVIN A IN HUMAN MARROW STROMAL CELLS AND THEIR IMPLICATIONS

1998 • 43 citations

The role of macrophage migration inhibitory factor in maintaining the immune privilege at the fetal–maternal interface

2007 • 40 citations

Relaxin and the Human Fetal Membranes

2007 • 33 citations

Thrombin regulates monocyte chemoattractant protein-1 expression in human first trimester and term decidual cells

2007 • 24 citations

Regulation of T‐Cell Activities at the Feto‐Placental Interface—by Placenta?

1999 • 19 citations

T Helper Cell Cytokine Profiles in Preterm Labor

2004 • 19 citations

Genetics of preterm labour

2007 • 15 citations

Dexamethasone Fails to Inhibit the Induction of Cytosolic Phospholipase A2 Expression by Interleukin-1β in Cultured Primary Human Amnion Fibroblasts

2005 • 8 citations