Effects on sister chromatid exchange frequency of polymorphisms in DNA repair gene XRCC1 in smokers

New Giemsa method for the differential staining of sister chromatids

1974 • 3,198 citations

Nonconservative amino acid substitution variants exist at polymorphic frequency in DNA repair genes in healthy humans.

1998 • 775 citations

Genetic polymorphism of CYP genes, alone or in combination, as a risk modifier of tobacco-related cancers.

2000 • 583 citations

XRCC1 polymorphisms: effects on aflatoxin B1-DNA adducts and glycophorin A variant frequency.

1999 • 575 citations

Human microsomal epoxide hydrolase: genetic poloymorphism and functional expression in vitro of amino acid variants

1994 • 491 citations

Polymorphisms in the DNA repair genes XRCC1 and ERCC2 and biomarkers of DNA damage in human blood mononuclear cells

2000 • 461 citations

Polymorphisms of the CYP1A1 and glutathione S-transferase genes associated with susceptibility to lung cancer in relation to cigarette dose in a Japanese population

1994 • 440 citations

Association between polymorphism in gene for microsomal epoxide hydrolase and susceptibility to emphysema

1997 • 439 citations

Genetic polymorphisms in DNA repair genes and risk of lung cancer

2001 • 323 citations

Polymorphisms of DNA repair gene XRCC1 in squamous cell carcinoma of the head and neck

1999 • 317 citations

Epoxide hydrolases: biochemistry and molecular biology

2000 • 300 citations

DNA repair gene polymorphisms, bulky DNA adducts in white blood cells and bladder cancer in a case-control study

2001 • 299 citations

Associations of CYP1A1, GSTM1, and CYP2E1 polymorphisms with lung cancer suggest cell type specificities to tobacco carcinogens.

1998 • 263 citations

DNA repair gene XRCC1 polymorphisms, smoking, and bladder cancer risk.

2001 • 236 citations

Variation in DNA repair is a factor in cancer susceptibility: a paradigm for the promises and perils of individual and population risk estimation?

1998 • 232 citations

The XRCC1 399 glutamine allele is a risk factor for adenocarcinoma of the lung

2001 • 225 citations

The 399Gln polymorphism in the DNA repair gene XRCC1 modulates the genotoxic response induced in human lymphocytes by the tobacco-specific nitrosamine NNK

2000 • 207 citations

Polymorphisms of the DNA repair geneXRCC1 and risk of gastric cancer in a Chinese population

2000 • 207 citations

Modulation of benzo[a]pyrene diolepoxide-DNA adduct levels in human white blood cells by CYP1A1, GSTM1 and GSTT1 polymorphism

2000 • 177 citations

Association between lung cancer and microsomal epoxide hydrolase genotypes.

1998 • 176 citations

Human glutathione S-transferase μ (GSTμ) deficiency as a marker for the susceptibility to bladder and larynx cancer among smokers

1993 • 162 citations

Nucleotide excision repair and the link with transcription

1995 • 153 citations

Polymorphism of Glutathione S-Transferase M1 and Lung Cancer Risk Among African-Americans and Caucasians in Los Angeles County, California

1995 • 152 citations

Mutations in hamster single-strand break repair gene XRCC1 causing defective DNA repair

1998 • 127 citations

Lung cancer risk of GSTM1 null genotype is dependent on the extent of tobacco smoke exposure

1994 • 115 citations

Domain specific interaction in the XRCC1-DNA polymerase beta complex

2000 • 114 citations

A Chinese hamster ovary cell mutant (EM-C11) with sensitivity to simple alkylating agents and a very high level of sister chromatid exchanges

1992 • 94 citations

Glutathione S-transferase M1 polymorphism and lung cancer risk in African-Americans

2000 • 91 citations

A case-control study of microsomal epoxide hydrolase, smoking, meat consumption, glutathione S-transferase M3, and risk of colorectal adenomas.

2001 • 88 citations

The interaction between microsomal epoxide hydrolase polymorphisms and cumulative cigarette smoking in different histological subtypes of lung cancer.

2001 • 87 citations

The Human Microsomal Epoxide Hydrolase Gene (EPHX1): Complete Nucleotide Sequence and Structural Characterization

1994 • 82 citations

The effect of tobacco on lung cancer risk depends on CYP2D6 activity

1996 • 69 citations

Oxygen radicals potentiate the genetic toxicity of tobacco‐specific nitrosamines

1993 • 60 citations

The GST T1 and CYP2E1 genotypes are possible factors causing vinyl chloride induced abnormal liver function

1997 • 58 citations

Modulation of DNA and protein adducts in smokers by genetic polymorphisms in GSTM1, GSTT1, NAT1 and NAT2

2001 • 57 citations

Glutathione S-transferase mu genotype, diet, and smoking as determinants of sister chromatid exchange frequency in lymphocytes.

1995 • 50 citations

Gene polymorphism for microsomal epoxide hydrolase and susceptibility to emphysema in a Japanese population

2000 • 49 citations

The association of microsomal epoxide hydrolase polymorphisms and lung cancer risk in African-Americans and Mexican-Americans

2001 • 48 citations

Role of polymorphic GSTM1 and GSTT1 genotypes on NNK-induced genotoxicity

1999 • 38 citations

Exposure to epichlorohydrin and dimethylformamide, glutathione S-transferases and sister chromatid exchange frequencies in peripheral lymphocytes

1999 • 32 citations

Repair of Oxidative DNA Damage In Vitro: A Tool for Screening Antioxidative Compounds

1999 • 23 citations