EARLY RENAL ISCHEMIA, WITH OR WITHOUT REPERFUSION, ACTIVATES NFκB AND INCREASES TNF-α BIOACTIVITY IN THE KIDNEY

NF-κB: Ten Years After

1996 • 3,008 citations

Multiple nuclear factors interact with the immunoglobulin enhancer sequences

1986 • 2,771 citations

Shock and Tissue Injury Induced by Recombinant Human Cachectin

1986 • 2,587 citations

Passive Immunization Against Cachectin/Tumor Necrosis Factor Protects Mice from Lethal Effect of Endotoxin

1985 • 2,380 citations

NF-κB: A pleiotropic mediator of inducible and tissue-specific gene control

1989 • 1,622 citations

The “initiator” as a transcription control element

1989 • 1,597 citations

Tumor necrosis factor (cachectin) is an endogenous pyrogen and induces production of interleukin 1.

1986 • 1,501 citations

Kidney Injury Molecule-1 (KIM-1), a Putative Epithelial Cell Adhesion Molecule Containing a Novel Immunoglobulin Domain, Is Up-regulated in Renal Cells after Injury

1998 • 1,189 citations

Renal Dysfunction after Myocardial Revascularization: Risk Factors, Adverse Outcomes, and Hospital Resource Utilization

1998 • 1,070 citations

Regulation of tumor necrosis factor alpha transcription in macrophages: involvement of four kappa B-like motifs and of constitutive and inducible forms of NF-kappa B.

1990 • 900 citations

Kappa B-type enhancers are involved in lipopolysaccharide-mediated transcriptional activation of the tumor necrosis factor alpha gene in primary macrophages.

1990 • 826 citations

Activation of the MAP kinase pathway by the protein kinase raf

1992 • 816 citations

Efficacy and Safety of Monoclonal Antibody to Human Tumor Necrosis Factor α in Patients With Sepsis Syndrome

1995 • 805 citations

Intercellular adhesion molecule-1-deficient mice are protected against ischemic renal injury.

1996 • 723 citations

The cytokine-adhesion molecule cascade in ischemia/reperfusion injury of the rat kidney. Inhibition by a soluble P-selectin ligand.

1997 • 503 citations

p55 Tumor Necrosis Factor Receptor Fusion Protein in the Treatment of Patients With Severe Sepsis and Septic Shock

1997 • 376 citations

Cytokine mRNA expression in postischemic/reperfused myocardium.

1995 • 375 citations

Leukocytes, cell adhesion molecules and ischemic acute renal failure

1997 • 281 citations

REVIEW ARTICLE: THE ROLE OF TUMOR NECROSIS FACTOR IN RENAL ISCHEMIA-REPERFUSION INJURY

1999 • 277 citations

Characterization of a transient outward K⁺ current with inward rectification in canine ventricular myocytes

1998 • 256 citations

Tumor necrosis factor induces glomerular damage in the rabbit.

1989 • 244 citations

The tissue distribution of tumor necrosis factor biosynthesis during endotoxemia.

1992 • 228 citations

The role of the B7 costimulatory pathway in experimental cold ischemia/reperfusion injury.

1997 • 228 citations

Necrosis and apoptosis in acute renal failure.

1998 • 214 citations

Early activation of transcription factor NF-κB during ischemia in perfused rat heart

1999 • 213 citations

Hemorrhage increases cytokine expression in lung mononuclear cells in mice: involvement of catecholamines in nuclear factor-kappaB regulation and cytokine expression.

1997 • 189 citations

Hemorrhage induces an increase in serum TNF which is not associated with elevated levels of endotoxin

1990 • 186 citations

Efficacy and safety of monoclonal antibody to human tumor necrosis factor alpha in patients with sepsis syndrome. A randomized, controlled, double-blind, multicenter clinical trial. TNF-alpha MAb Sepsis Study Group

1995 • 153 citations

Role of IL-1 in renal ischemic reperfusion injury.

1998 • 149 citations

Hemorrhage Activates Myocardial NFκB and Increases TNF-α in the Heart

1997 • 136 citations

Hydrogen peroxide induces tumor necrosis factor α–mediated cardiac injury by a P38 mitogen-activated protein kinase–dependent mechanism

1998 • 114 citations

PREVENTION OF LATE RENAL CHANGES AFTER INITIAL ISCHEMIA/REPERFUSION INJURY BY BLOCKING EARLY SELECTIN BINDING1

1997 • 110 citations

CD28-B7 blockade in organ dysfunction secondary to cold ischemia/reperfusion injury: Rapid Communication

1997 • 106 citations

Involvement of tumor necrosis factor and platelet-activating factor in the pathogenesis of experimental nephrosis in rats.

1994 • 105 citations

Ischemic preconditioning decreases postischemic myocardial tumor necrosis factor-alpha production. Potential ultimate effector mechanism of preconditioning.

1998 • 105 citations

PROTECTIVE EFFECT OF EXOGENOUS NITRIC OXIDE ON THE RENAL FUNCTION AND INFLAMMATORY RESPONSE IN A MODEL OF ISCHEMIA-REPERFUSION1

1998 • 93 citations

Prevention of crescentic glomerulonephritis induced by anti-glomerular membrane antibody in tumor necrosis factor-deficient mice.

1998 • 91 citations

Human Myocardial Tissue TNF Expression Following Acute Global Ischemia

1998 • 87 citations

Hemorrhage induces rapid in vivo activation of CREB and NF-kappaB in murine intraparenchymal lung mononuclear cells.

1997 • 73 citations

Adenosine decreases post‐ischaemic cardiac TNF‐α production: anti‐inflammatory implications for preconditioning and transplantation

1997 • 71 citations

The Impact of Complications after Vascular Surgery in Veterans Affairs Medical Centers

1997 • 68 citations

Adaptive and Maladaptive Mechanisms of Cellular Priming

1997 • 67 citations

p55 Tumor necrosis factor receptor fusion protein in the treatment of patients with severe sepsis and septic shock. A randomized controlled multicenter trial. Ro 45-2081 Study Group

1997 • 66 citations

The role of macrophages and reactive oxygen species in experimental hydronephrosis.

1998 • 64 citations

Hypoxia induces intercellular adhesion molecule-1 on cultured human tubular cells

1997 • 49 citations

The expression of mRNA for tumour necrosis factor‐α increases in the obstructed kidney of rats soon after unilateral ureteral ligation

1996 • 45 citations

Cause of acute tubular necrosis affects its prognosis. The Auriculin Anaritide Acute Renal Failure Study Group

1997 • 37 citations

Cause of Acute Tubular Necrosis Affects Its Prognosis

1997 • 36 citations

Association between decreased splenic ATP levels and immunodepression: amelioration with ATP-MgCl2

1991 • 32 citations

Mechanism of diltiazem's immunomodulatory effects after hemorrhage and resuscitation

1993 • 28 citations

α-Adrenergic Activation of Myocardial NFκB during Hemorrhage

1997 • 26 citations

Fibronectin augments monocyte adhesion to low-density lipoprotein–stimulated mesangial cells

1999 • 26 citations

Energetics of defective macrophage antigen presentation after hemorrhage as determined by ultraresolution 31P nuclear magnetic resonance spectrometry: restoration with adenosine triphosphate-MgCl2.

1992 • 22 citations

Sepsis therapy trials. Continued disappointment or reason for hope?

1994 • 8 citations