ANALYSIS OF THE B7 COSTIMULATORY PATHWAY IN ALLOGRAFT REJECTION1

Enhancement of Antitumor Immunity by CTLA-4 Blockade

1996 • 3,585 citations

CTLA-4 can function as a negative regulator of T cell activation

1994 • 2,107 citations

CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation.

1995 • 2,090 citations

B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: Application to autoimmune disease therapy

1995 • 1,695 citations

CTLA-4 is a second receptor for the B cell activation antigen B7.

1991 • 1,662 citations

Fas(CD95)/FasL interactions required for programmed cell death after T-cell activation

1995 • 1,549 citations

A new rapid and simple non-radioactive assay to monitor and determine the proliferation of lymphocytes: an alternative to [3H]thymidine incorporation assay

1994 • 1,332 citations

Costimulation of T lymphocytes: the role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy

1992 • 1,290 citations

Differential T Cell Costimulatory Requirements in CD28-Deficient Mice

1993 • 1,271 citations

A new member of the immunoglobulin superfamily—CTLA-4

1987 • 1,214 citations

Long-Term Survival of Xenogeneic Pancreatic Islet Grafts Induced by CTLA4lg

1992 • 1,156 citations

Tumor Rejection After Direct Costimulation of CD8 ⁺ T Cells by B7-Transfected Melanoma Cells

1993 • 1,154 citations

B70 antigen is a second ligand for CTLA-4 and CD28

1993 • 907 citations

PRIMARILY VASCULARIZED ALLOGRAFTS OF HEARTS IN MICE

1973 • 801 citations

Comparative analysis of B7-1 and B7-2 costimulatory ligands: expression and function.

1994 • 681 citations

Differential effects of anti-B7-1 and anti-B7-2 monoclonal antibody treatment on the development of diabetes in the nonobese diabetic mouse.

1995 • 595 citations

B7-1 and B7-2 do not deliver identical costimulatory signals, since B7-2 but not B7-1 preferentially costimulates the initial production of IL-4

1995 • 577 citations

T-cell activation by the CD28 ligand B7 is required for cardiac allograft rejection in vivo.

1992 • 558 citations

New perspectives of C1328-137-mediated T cell costimulation

1995 • 526 citations

Identification of an Alternative CTLA-4 Ligand Costimulatory for T Cell Activation

1993 • 517 citations

Tumor immunogenicity determines the effect of B7 costimulation on T cell-mediated tumor immunity.

1994 • 482 citations

Costimulatory function and expression of CD40 ligand, CD80, and CD86 in vascularized murine cardiac allograft rejection

1996 • 416 citations

Absence of B7-dependent responses in CD28-deficient mice

1994 • 386 citations

Regulation of immunostimulatory function and costimulatory molecule (B7-1 and B7-2) expression on murine dendritic cells.

1994 • 379 citations

Uncovering of Functional Alternative CTLA-4 Counter-Receptor in B7-Deficient Mice

1993 • 369 citations

Murine B7-2, an alternative CTLA4 counter-receptor that costimulates T cell proliferation and interleukin 2 production.

1993 • 357 citations

CD40-gp39 INTERACTIONS PLAY A CRITICAL ROLE DURING ALLOGRAFT REJECTION

1996 • 331 citations

Functional expression of the costimulatory molecule, B7/BB1, on murine dendritic cell populations.

1992 • 306 citations

TRANSPLANTATION TOLERANCE INDUCED BY CTLA4-Ig1

1994 • 303 citations

TRANSPLANTATION TOLERANCE INDUCED BY CTLA4-Ig1

1994 • 294 citations

Expression and functional significance of an additional ligand for CTLA-4.

1993 • 262 citations

Dendritic cells stimulate primary human cytolytic lymphocyte responses in the absence of CD4+ helper T cells.

1990 • 210 citations

CD28 costimulation inhibits TCR-induced apoptosis during a primary T cell response.

1996 • 198 citations

INHIBITION OF TRANSPLANT REJECTION FOLLOWING TREATMENT WITH ANTI-B7-2 AND ANTI-B7-1 ANTIBODIES

1995 • 165 citations

The murine homologue of the T lymphocyte antigen CD28. Molecular cloning and cell surface expression.

1990 • 141 citations

Unusual intron in the immunoglobulin domain of the newly isolated murine CD4 (L3T4) gene

1987 • 127 citations

Molecular cloning of Lyt-2, a membrane glycoprotein marking a subset of mouse T lymphocytes: molecular homology to its human counterpart, Leu-2/T8, and to immunoglobulin variable regions.

1985 • 101 citations

SKIN ALLOGRAFT REJECTION IN CD28-DEFICIENT MICE1

1996 • 93 citations

Mutational analysis and an alternatively spliced product of B7 defines its CD28/CTLA4-binding site on immunoglobulin C-like domain.

1995 • 52 citations

Identification of an Alternatively Spliced Form of the Murine Homolog of B7

1994 • 40 citations

Characterization of the murine B7-1 genomic locus reveals an additional exon encoding an alternative cytoplasmic domain and a chromosomal location of chromosome 16, band B5.

1994 • 39 citations

Subcellular localization of CD80 receptors is dependent on an intact cytoplasmic tail and is required for CD28-dependent T cell costimulation.

1996 • 32 citations

The role of the B7-1a molecule, an alternatively spliced form of murine B7-1 (CD80), on T cell activation.

1996 • 31 citations

Genomic organization of the mouse B-lymphocyte activation antigen B7

1993 • 20 citations