Nicotinic acetylcholine receptor contains multiple binding sites: evidence from binding of alpha-dendrotoxin.

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues

2013 • 47,043 citations

Fluorescamine: A Reagent for Assay of Amino Acids, Peptides, Proteins, and Primary Amines in the Picomole Range

1972 • 2,632 citations

A study of the ‘desensitization’ produced by acetylcholine at the motor end‐plate

1957 • 1,457 citations

Structural homology of Torpedo californica acetylcholine receptor subunits

1983 • 798 citations

Acetylcholine Receptor: Complex of Homologous Subunits

1980 • 594 citations

The Nicotinic Cholinergic Receptor: Correlation of Molecular Structure with Functional Properties

1982 • 456 citations

Cloning and sequence analysis of calf cDNA and human genomic DNA encoding α-subunit precursor of muscle acetylcholine receptor

1983 • 433 citations

A simple assay for the study of solubilized acetylcholine receptors

1973 • 416 citations

Identification of the alpha subunit half-cystine specifically labeled by an affinity reagent for the acetylcholine receptor binding site.

1984 • 408 citations

[43] Analysis of phenylthiohydantoins by ultrasensitive gradient high-performance liquid chromatography

1983 • 358 citations

Acetylcholine and local anesthetic binding to Torpedo nicotinic postsynaptic membranes after removal of nonreceptor peptides.

1979 • 350 citations

Advances in Cytopharmacology

1973 • 345 citations

Affinity-labeling of purified acetylcholine receptor from Torpedo californica

1974 • 243 citations

Equilibrium binding of [3H]tubocurarine and [3H]acetylcholine by torpedo postsynaptic membranes: stoichiometry and ligand interactions

1979 • 243 citations

Voltage dependence of agonist effectiveness at the frog neuromuscular junction: resolution of a paradox.

1975 • 190 citations

Purification of Torpedo californica post-synaptic membranes and fractionation of their constituent proteins

1980 • 176 citations

Isolation of a clone coding for the alpha-subunit of a mouse acetylcholine receptor

1985 • 169 citations

An analysis of the dose‐response relationship at voltage‐clamped frog neuromuscular junctions.

1978 • 162 citations

Bromoacetylcholine as an affinity label of the acetylcholine receptor from Torpedo californica

1978 • 160 citations

Isolation and characterization of a cDNA clone for the complete protein coding region of the delta subunit of the mouse acetylcholine receptor.

1984 • 155 citations

Brain and muscle nicotinic acetylcholine receptors are different but homologous proteins.

1985 • 154 citations

Determination of dose‐response curves by quantitative ionophoresis at the frog neuromuscular junction.

1978 • 147 citations

Facets of the Structures of Acetylcholine Receptors from Electrophorus and Torpedo

1976 • 142 citations

Primary structure of delta subunit precursor of calf muscle acetylcholine receptor deduced from cDNA sequence

1985 • 134 citations

Structure linkage, and sequence of the two genes encoding the delta and gamma subunits of the nicotinic acetylcholine receptor.

1984 • 132 citations

Restoration of 125I-alpha-bungarotoxin binding activity to the alpha subunit of Torpedo acetylcholine receptor isolated by gel electrophoresis in sodium dodecyl sulfate.

1981 • 128 citations

The arrangement of the subunits of the acetylcholine receptor of Torpedo californica.

1983 • 115 citations

Cloning and sequence analysis of human genomic DNA encoding γ subunit precursor of muscle acetylcholine receptor

1985 • 114 citations

Binding of alpha-bungarotoxin to isolated alpha subunit of the acetylcholine receptor of Torpedo californica: quantitative analysis with protein blots.

1983 • 113 citations

Stoichiometry of the Ligand-Binding Sites in the Acetylcholine-Receptor Oligomer from Muscle and from Electric Organ. Measurement by Affinity Alkylation with Bromoacetylcholine

1980 • 110 citations

Interaction of [125I]-.alpha.-bungarotoxin with acetylcholine receptor from Torpedo californica

1979 • 100 citations

Injection of α-bungarotoxin near the suprachiasmatic nucleus blocks the effects of light on nocturnal pineal enzyme activity

1981 • 91 citations

Mammalian Muscle Acetylcholine Receptor: A Supramolecular Structure Formed by Four Related Proteins

1982 • 88 citations

Studies of reversible and irreversible interactions of an alkylating agonist with Torpedo californica acetylcholine receptor in membrane-bound and purified states

1979 • 88 citations

Antibodies to synthetic peptides as probes for the binding site on the alpha subunit of the acetylcholine receptor.

1985 • 85 citations

A new kind of drug antagonism: evidence that agonists cause a molecular change in acetylcholine receptors.

1969 • 83 citations

Nicotinic acetylcholine receptor from chick optic lobe.

1982 • 83 citations

A Model Of The Three‐Dimensional Structure Of Snake Venom Neurotoxins Based On Chemical Evidence

1973 • 82 citations

Neuronal-like features of TE671 cells: Presence of a functional nicotinic cholinergic receptor

1982 • 69 citations

Affinity-directed crosslinking of membrane-bound acetylcholine receptor polypeptides with photolabile .alpha.-bungarotoxin derivatives

1979 • 66 citations

Photoaffinity labeling and quaternary structure of the acetylcholine receptor from Torpedo californica.

1976 • 66 citations

Subunit structure of the acetylcholine receptor from Electrophorus electricus.

1982 • 63 citations

Specific binding of perhydrohistrionicotoxin to Torpedo acetylcholine receptor.

1979 • 62 citations

Selective photoaffinity labeling of acetylcholine receptor using a cholinergic analog

1977 • 61 citations

Postsynaptic membranes in the electric tissue of Narcine: IV. Isolation and characterization of the nicotinic receptor protein

1977 • 60 citations

The relationship between desensitization and the metaphilic effect at cholinergic receptors.

1970 • 60 citations

Effect of Dendroaspis neurotoxins on synaptic transmission in the spinal cord of the frog

1975 • 58 citations

Activation and desensitization of Torpedo acetylcholine receptor: evidence for separate binding sites.

1982 • 58 citations

Relaxation experiments using bath‐applied suberyldicholine.

1977 • 56 citations

Isolation of cholinergic receptor protein(s) from Torpedo nobiliana by affinity chromatography

1974 • 56 citations

Structure and function of snake venom curarimimetic neurotoxins.

1978 • 56 citations

The Primary Sequences and Neuromuscular Effects of Three Neurotoxic Polypeptides from the Venom of Dendroaspis Viridis

1974 • 55 citations

Separate sites of low and high affinity for agonists on Torpedo californica acetylcholine receptor

1983 • 55 citations

Multiple binding sites for agonists on Torpedo californica acetylcholine receptor

1982 • 53 citations

Arrangement of the subunits of the nicotinic acetylcholine receptor of Torpedo californica as determined by .alpha.-neurotoxin crosslinking

1985 • 38 citations

The Nicotinic Acetylcholine Receptor: Subunit Structure, Functional Binding Sites, and Ion Transport Properties

1983 • 31 citations

Separation and Characterization of Polypeptides from the Venom of Dendroaspis viridis

1973 • 25 citations

Detection of low-affinity .alpha.-bungarotoxin binding sites in the rat central nervous system

1984 • 19 citations

The Amino‐Acid Sequence of a Polypeptide from the Venom of Dendroaspis viridis

1974 • 18 citations

Binding properties of a neurotoxin from the venom of the green mamba, Dendroaspis viridis.

1980 • 17 citations

Acetylcholine receptors in and out of membranes.

1979 • 10 citations

Proceedings: Effect of alpha-bungarotoxin and dendroaspis neurotoxins on acetylcholine responses of snail neurones.

1974 • 6 citations