Degeneration in vivo of rat hippocampal neurons by wild-type Alzheimer amyloid precursor protein overexpressed by adenovirus-mediated gene transfer.

The Rat Brain in Stereotaxic Coordinates

1982 • 53,055 citations

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.

1992 • 9,540 citations

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

1984 • 5,166 citations

Efficient selection for high-expression transfectants with a novel eukaryotic vector

1991 • 5,120 citations

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

1987 • 4,544 citations

Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice

1996 • 4,118 citations

Cellular Scaling Rules for the Brains of Marsupials: Not as “Primitive” as Expected

2017 • 2,600 citations

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

1995 • 2,456 citations

NeuN, a neuronal specific nuclear protein in vertebratesxs

1992 • 2,268 citations

Cleavage of Amyloid β Peptide During Constitutive Processing of Its Precursor

1990 • 1,388 citations

Delayed neuronal death in the CA1 pyramidal cell layer of the gerbil hippocampus following transient ischemia is apoptosis

1995 • 834 citations

Efficient generation of recombinant adenoviruses using adenovirus DNA-terminal protein complex and a cosmid bearing the full-length virus genome.

1996 • 804 citations

An Adenovirus Vector for Gene Transfer into Neurons and Glia in the Brain

1993 • 746 citations

Precursor of amyloid protein in Alzheimer disease undergoes fast anterograde axonal transport.

1990 • 735 citations

Microglia in degenerative neurological disease

1993 • 594 citations

A model system for in vivo gene transfer into the central nervous system using an adenoviral vector

1993 • 588 citations

Immunohistochemical evidence for apoptosis in Alzheimerʼs disease

1994 • 569 citations

Transfer of a foreign gene into the brain using adenovirus vectors

1993 • 538 citations

Aβ Deposition Is Associated with Neuropil Changes, but not with Overt Neuronal Loss in the Human Amyloid Precursor Protein V717F (PDAPP) Transgenic Mouse

1997 • 502 citations

Cell death in Alzheimer's disease evaluated by DNA fragmentation in situ

1995 • 450 citations

A SIMPLE AND EFFICIENT METHOD FOR PURIFICATION OF INFECTIOUS RECOMBINANT ADENOVIRUS

1994 • 445 citations

Protease nexin-II, a potent anti-chymotrypsin, shows identity to amyloid β-protein precursor

1989 • 437 citations

Direct in vivo gene transfer to ependymal cells in the central nervous system using recombinant adenovirus vectors

1993 • 387 citations

An improved staining method for rat microglial cells using the lectin from Griffonia simplicifolia (GSA I-B4).

1990 • 380 citations

Persistence of cholinergic neurons in the basal nucleus in a brain with senile dementia of the Alzheimer's type demonstrated by immunohistochemical staining for choline acetyltransferase

1983 • 332 citations

Cell loss and shrinkage in the nucleus basalis Meynert complex in Alzheimer's disease

1990 • 278 citations

Increased expression of beta-amyloid precursor protein during neuronal differentiation is not accompanied by secretory cleavage.

1992 • 180 citations

Degeneration in vitro of post-mitotic neurons overexpressing the Alzheimer amyloid protein precursor

1992 • 175 citations

The amyloid precursor protein is concentrated in neuronal lysosomes in normal and Alzheimer disease subjects

1989 • 142 citations

Aggregation of the amyloid precursor protein within degenerating neurons and dystrophic neurites in alzheimer's disease

1992 • 120 citations

THE IMMUNOHISTOCHEMICAL DEMONSTRATION OF SUBSEQUENCES OF THE PRECURSOR OF THE AMYLOID A4 PROTEIN IN SENILE PLAQUES IN ALZHEIMER'S DISEASE

1989 • 119 citations

Comparison of intracerebral inoculation and osmotic blood-brain barrier disruption for delivery of adenovirus, herpesvirus, and iron oxide particles to normal rat brain.

1995 • 119 citations

Cell loss in the nucleus raphes dorsalis in alzheimer's disease

1992 • 115 citations

Formation of amyloid-like fibrils in COS cells overexpressing part of the Alzheimer amyloid protein precursor

1990 • 113 citations

Adenoviral vectors as functional retrograde neuronal tracers

1994 • 74 citations

Accumulation of amyloid precursor fragment in Alzheimer plaques

1991 • 67 citations

Neural differentiation increases expression of Alzheimer amyloid protein precursor gene in murine embryonal carcinoma cells

1990 • 42 citations

Protease inhibitors generate cytotoxic fragments from alzheimer amyloid protein precursor in cDNA-transfected glioma cells

1992 • 33 citations

Glutamate responsiveness enhanced in neurones expressing amyloid precursor protein

1997 • 14 citations