Recognition of Tmiddle dotG mismatched base pairs in DNA by stacked imidazole-containing polyamides: surface plasmon resonance and circular dichroism studies

A map of human genome sequence variation containing 1.42 million single nucleotide polymorphisms

2001 • 2,948 citations

Pharmacogenomics: Translating Functional Genomics into Rational Therapeutics

1999 • 2,458 citations

Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes

1988 • 2,121 citations

Cellular Oncogenes and Multistep Carcinogenesis

1983 • 1,154 citations

Improving biosensor analysis

1999 • 753 citations

Thermodynamics and NMR of Internal G·T Mismatches in DNA

1997 • 588 citations

GC base sequence recognition by oligoimidazolecarboxamide and C-terminus-modified analogs of distamycin deduced from circular dichroism, proton nuclear magnetic resonance, and methidiumpropylethylenediaminetetraacetate-iron(II) footprinting studies

1993 • 394 citations

Structural characterization of a 2:1 distamycin A.d(CGCAAATTGGC) complex by two-dimensional NMR.

1989 • 389 citations

A 5-nanosecond molecular dynamics trajectory for B-DNA: analysis of structure, motions, and solvation

1997 • 292 citations

Sequence-specific DNA recognition by polyamides

1999 • 279 citations

Binding modes of distamycin A with d(CGCAAATTTGCG)2 determined by two-dimensional NMR

1990 • 218 citations

Scanning of guanine–guanine mismatches in DNA by synthetic ligands using surface plasmon resonance

2001 • 217 citations

The NMR Structure of a DNA Dodecamer in an Aqueous Dilute Liquid Crystalline Phase

2000 • 202 citations

Determination of the Refractive Index Increments of Small Molecules for Correction of Surface Plasmon Resonance Data

2000 • 181 citations

The structure of guanosine-thymidine mismatches in B-DNA at 2.5-A resolution.

1987 • 177 citations

A Versatile Mismatch Recognition Agent: Specific Cleavage of a Plasmid DNA at a Single Base Mispair

1999 • 146 citations

Interaction of minor groove ligands to an AAATT/AATTT site: correlation of thermodynamic characterization and solution structure

1995 • 119 citations

Wobble dG.cntdot.dT pairing in right-handed DNA: solution conformation of the d(C-G-T-G-A-A-T-T-C-G-C-G) duplex deduced from distance geometry analysis of nuclear Overhauser effect spectra

1986 • 103 citations

Molecular dynamics simulation study of DNA dodecamer d(CGCGAATTCGCG) in solution: conformation and hydration

1997 • 103 citations

Influence of the Dynamic Positions of Cations on the Structure of the DNA Minor Groove: Sequence-Dependent Effects

2001 • 97 citations

Pharmacogenetic applications of the Human Genome project

2001 • 94 citations

NMR solution structure of a DNA dodecamer containing single G*T mismatches

1998 • 93 citations

Influence of a Terminal Formamido Group on the Sequence Recognition of DNA by Polyamides

2002 • 79 citations

DNA mismatch repair and colorectal cancer

1998 • 62 citations

K-ras mutations in duodenal aspirate without secretin stimulation for screening of pancreatic and biliary tract carcinoma

1999 • 45 citations

Solution structure of DAPI selectively bound in the minor groove of a DNA T{middle dot}T mismatch-containing site: NMR and molecular dynamics studies

1998 • 44 citations

Imidazole-imidazole pair as a minor groove recognition motif for T:G mismatched base pairs

1999 • 43 citations

Binding of AR‐1‐144, a tri‐imidazole DNA minor groove binder, to CCGG sequence analyzed by NMR spectroscopy

1999 • 26 citations

Hydroxybenzamide/Pyrrole Pair Distinguishes T·A from A·T Base Pairs in the Minor Groove of DNA

2000 • 23 citations

Recognition of GT mismatches by Vsr mismatch endonuclease

2000 • 22 citations

Sequence-Directed Base Mispairing in Human Oncogenes

1998 • 3 citations