Metformin Suppresses Ovarian Cancer Growth and Metastasis with Enhancement of Cisplatin Cytotoxicity In Vivo

Cancer Statistics, 2010

2010 • 12,557 citations

Dose translation from animal to human studies revisited

2007 • 5,463 citations

Metformin Selectively Targets Cancer Stem Cells, and Acts Together with Chemotherapy to Block Tumor Growth and Prolong Remission

2009 • 1,063 citations

The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level

2008 • 835 citations

Metformin in Cancer Therapy: A New Perspective for an Old Antidiabetic Drug?

2010 • 473 citations

Effect of metformin on life span and on the development of spontaneous mammary tumors in HER-2/neu transgenic mice

2005 • 393 citations

AMP-activated Protein Kinase (AMPK) Signaling in Endothelial Cells Is Essential for Angiogenesis in Response to Hypoxic Stress

2003 • 332 citations

Prevention of pancreatic cancer induction in hamsters by metformin

2001 • 331 citations

Characterization of intraperitoneal, orthotopic, and metastatic xenograft models of human ovarian cancer

2004 • 271 citations

In vitro metformin anti-neoplastic activity in epithelial ovarian cancer

2008 • 266 citations

Metformin blocks the stimulative effect of a high-energy diet on colon carcinoma growth in vivo and is associated with reduced expression of fatty acid synthase

2010 • 231 citations

Metformin attenuates ovarian cancer cell growth in an AMP‐kinase dispensable manner

2009 • 222 citations

Metformin: A Therapeutic Opportunity in Breast Cancer

2010 • 202 citations

AMPK‐mediated autophagy inhibits apoptosis in cisplatin‐treated tumour cells

2009 • 184 citations

Metformin suppresses intestinal polyp growth in Apc^Min/+ mice

2008 • 179 citations

Current Management Strategies for Ovarian Cancer

2007 • 176 citations

Therapeutic metformin/AMPK activation promotes the angiogenic phenotype in the ERα negative MDA-MB-435 breast cancer model

2008 • 174 citations

Glucose Deprivation Increases mRNA Stability of Vascular Endothelial Growth Factor through Activation of AMP-activated Protein Kinase in DU145 Prostate Carcinoma

2005 • 146 citations

Current Management Strategies for Ovarian Cancer

2007 • 129 citations

Metformin decreases angiogenesis via NF-κB and Erk1/2/Erk5 pathways by increasing the antiangiogenic thrombospondin-1

2009 • 110 citations

Dietary energy availability affects primary and metastatic breast cancer and metformin efficacy

2009 • 94 citations

Metformin blocks migration and invasion of tumour cells by inhibition of matrix metalloproteinase‐9 activation through a calcium and protein kinase Cα‐dependent pathway: phorbol‐12‐myristate‐13‐acetate‐induced/extracellular signal‐regulated kinase/activator protein‐1

2010 • 92 citations

Metformin inhibits inflammatory angiogenesis in a murine sponge model

2009 • 66 citations