Newly Recognized Components of the Renin-Angiotensin System: Potential Roles in Cardiovascular and Renal Regulation
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References (151)
A Novel Angiotensin-Converting Enzyme–Related Carboxypeptidase (ACE2) Converts Angiotensin I to Angiotensin 1-9
2000 • 3,055 citations
International union of pharmacology. XXIII. The angiotensin II receptors.
2000 • 2,055 citations
A Human Homolog of Angiotensin-converting Enzyme
2000 • 1,970 citations
Angiotensin-converting enzyme 2 is an essential regulator of heart function
2002 • 1,745 citations
Molecular characterization of angiotensin II--induced hypertrophy of cardiac myocytes and hyperplasia of cardiac fibroblasts. Critical role of the AT1 receptor subtype.
1993 • 1,420 citations
Renin-angiotensin system: biochemistry and mechanisms of action.
1977 • 1,373 citations
Autocrine release of angiotensin II mediates stretch-induced hypertrophy of cardiac myocytes in vitro
1993 • 1,347 citations
Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin
2002 • 1,265 citations
Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin
2002 • 1,096 citations
Effects on blood pressure and exploratory behaviour of mice lacking angiotensin II type-2 receptor
1995 • 858 citations
Expression cloning of type 2 angiotensin II receptor reveals a unique class of seven-transmembrane receptors.
1993 • 767 citations
Behavioural and cardiovascular effects of disrupting the angiotensin II type-2 receptor gene in mice
1995 • 740 citations
Contribution of kinins to the cardiovascular actions of angiotensin-converting enzyme inhibitors.
1995 • 642 citations
Circulating and tissue angiotensin systems.
1987 • 616 citations
Effects of angiotensin-converting enzyme inhibitors and angiotensin II type 1 receptor antagonists in rats with heart failure. Role of kinins and angiotensin II type 2 receptors.
1997 • 603 citations
Angiotensin II type 2 receptor overexpression activates the vascular kinin system and causes vasodilation
1999 • 558 citations
AT1-receptor heterodimers show enhanced G-protein activation and altered receptor sequestration
2000 • 487 citations
Increased AT1 receptor heterodimers in preeclampsia mediate enhanced angiotensin II responsiveness
2001 • 485 citations
The subtype 2 (AT2) angiotensin receptor mediates renal production of nitric oxide in conscious rats.
1997 • 481 citations
Recent Progress in Angiotensin II Type 2 Receptor Research in the Cardiovascular System
1999 • 472 citations
Physiology and Pathophysiology of the Adipose Tissue Renin-Angiotensin System
2000 • 467 citations
The Angiotensin II AT2 Receptor Is an AT1Receptor Antagonist
2001 • 459 citations
Role of the Angiotensin Type 2 Receptor in the Regulation of Blood Pressure and Renal Function
2000 • 417 citations
Molecular biology of the renin-angiotensin system.
1993 • 403 citations
Angiotensin-(1-7) Dilates Canine Coronary Arteries Through Kinins and Nitric Oxide
1996 • 401 citations
Cellular localization and regional distribution of an angiotensin II-forming chymase in the heart.
1993 • 397 citations
The Cardiac Renin-Angiotensin System
1999 • 395 citations
Angiotensin-(1–7): an update
2000 • 383 citations
Regulation of Intrarenal Angiotensin II in Hypertension
2002 • 374 citations
In situ hybridization evidence for angiotensinogen messenger RNA in the rat proximal tubule. An hypothesis for the intrarenal renin angiotensin system.
1990 • 325 citations
Expression of the Subtype 2 Angiotensin (AT 2 ) Receptor Protein in Rat Kidney
1997 • 322 citations
Sustained hypersensitivity to angiotensin II and its mechanism in mice lacking the subtype-2 (AT 2 ) angiotensin receptor
1999 • 316 citations
Angiotensin-Forming Enzyme in Brain Tissue
1971 • 315 citations
The subtype-2 (AT2) angiotensin receptor regulates renal cyclic guanosine 3', 5'-monophosphate and AT1 receptor-mediated prostaglandin E2 production in conscious rats.
1996 • 311 citations
Cardiac renin and angiotensins. Uptake from plasma versus in situ synthesis.
1994 • 309 citations
Elements of a Paracrine Tubular Renin-Angiotensin System Along the Entire Nephron
1999 • 293 citations
Angiotensin II Type 2 Receptor Is Essential for Left Ventricular Hypertrophy and Cardiac Fibrosis in Chronic Angiotensin II–Induced Hypertension
2001 • 292 citations
Metabolism of Angiotensin-(1–7) by Angiotensin-Converting Enzyme
1998 • 290 citations
Release of vasopressin from the rat hypothalamo-neurohypophysial system by angiotensin-(1-7) heptapeptide.
1988 • 281 citations
Distribution of angiotensin AT1and AT2receptor subtypes in the rat kidney
1999 • 273 citations
Renin???angiotensin system
1992 • 264 citations
Angiotensin receptors: signaling, vascular pathophysiology, and interactions with ceramide
2001 • 256 citations
Angiotensin Type 2 Receptors Are Reexpressed by Cardiac Fibroblasts From Failing Myopathic Hamster Hearts and Inhibit Cell Growth and Fibrillar Collagen Metabolism
1997 • 250 citations
Specific receptor binding of renin on human mesangial cells in culture increases plasminogen activator inhibitor-1 antigen
1996 • 245 citations
Angiotensin-(1–7) Augments Bradykinin-Induced Vasodilation by Competing With ACE and Releasing Nitric Oxide
1997 • 245 citations
Protective Role of the Angiotensin AT 2 Receptor in a Renal Wrap Hypertension Model
1999 • 241 citations
Evidence for angiotensin II type 2 receptor–mediated cardiac myocyte enlargement during in vivo pressure overload
2000 • 232 citations
Renal Interstitial Fluid Concentrations of Angiotensins I and II in Anesthetized Rats
2002 • 230 citations
Angiotensin-(1–7) Contributes to the Antihypertensive Effects of Blockade of the Renin-Angiotensin System
1998 • 224 citations
Angiotensin II formation from ACE and chymase in human and animal hearts: methods and species considerations
1997 • 223 citations
Compartmentalization of angiotensin II generation in the dog heart. Evidence for independent mechanisms in intravascular and interstitial spaces.
1997 • 216 citations
Effects of angiotensin II on electrolyte transport in the early and late distal tubule in rat kidney
1996 • 206 citations
Converting Enzyme Determines Plasma Clearance of Angiotensin-(1–7)
1998 • 198 citations
Role of the intrarenal renin-angiotensin system in the control of renal function.
1981 • 195 citations
Endothelial renin-angiotensin pathway: evidence for intracellular synthesis and secretion of angiotensins.
1987 • 190 citations
PCR localization of angiotensin II receptor and angiotensinogen mRNAs in rat kidney
1993 • 187 citations
Enhancement of Angiotensinogen Expression in Angiotensin II–Dependent Hypertension
2001 • 183 citations
In vivo metabolism of angiotensin I by neutral endopeptidase (EC 3.4.24.11) in spontaneously hypertensive rats.
1992 • 182 citations
Renal proximal tubular AT2 receptor: signaling and transport.
1999 • 179 citations
Signal transduction mechanisms involved in angiotensin-(1-7)-stimulated arachidonic acid release and prostanoid synthesis in rabbit aortic smooth muscle cells.
1998 • 178 citations
Substrate-Based Design of the First Class of Angiotensin-Converting Enzyme-Related Carboxypeptidase (ACE2) Inhibitors
2002 • 178 citations
Renin synthesis by canine aortic smooth muscle cells in culture
1982 • 175 citations
Renin is not synthesized by cardiac and extrarenal vascular tissues. A review of experimental evidence.
1994 • 173 citations
Selective Downregulation of the Angiotensin II AT 1 -Receptor Subtype in Failing Human Ventricular Myocardium
1997 • 172 citations
Cardiac Angiotensin II Type 2 Receptor Activates the Kinin/NO System and Inhibits Fibrosis
2003 • 170 citations
Angiotensin receptor subtypes of the kidney cortex
1987 • 169 citations
Renal actions of angiotensin-(1-7): in vivo and in vitro studies
1996 • 169 citations
Prorenin, Renin, Angiotensinogen, and Angiotensin-Converting Enzyme in Normal and Failing Human Hearts
1997 • 168 citations
Angiotensin I converting enzyme in human intestine and kidney
1986 • 166 citations
The Site of Angiotensin Production
1985 • 165 citations
Gene expression and tissue localization of the two isoforms of angiotensin I converting enzyme.
1993 • 163 citations
Angiotensin Type 2 Receptor Mediates Valsartan-Induced Hypotension in Conscious Rats
2000 • 161 citations
Renin expression in renal proximal tubule.
1993 • 161 citations
Angiotensin-(1-7) Potentiates the Hypotensive Effect of Bradykinin in Conscious Rats
1995 • 161 citations
Differential distribution of angiotensin AT2 receptors in the normal and failing human heart.
1998 • 159 citations
Cellular Distribution of Angiotensin-Converting Enzyme After Myocardial Infarction
1995 • 157 citations
Cardiac angiotensinogen and its local activation in the isolated perfused beating heart.
1990 • 152 citations
Angiotensin II Type 2 Receptor Overexpression Preserves Left Ventricular Function After Myocardial Infarction
2002 • 152 citations
AT 2 Receptor-Mediated Relaxation Is Preserved After Long-Term AT 1 Receptor Blockade
2002 • 147 citations
Mannose 6-Phosphate Receptor–Mediated Internalization and Activation of Prorenin by Cardiac Cells
1997 • 146 citations
Effect of intrarenal angiotensin II blockade on renal function in conscious dogs.
1977 • 145 citations
Angiotensin Type 2 Receptor-Mediated Hypotension in Angiotensin Type-1 Receptor-Blocked Rats
2001 • 143 citations
Inhibition of pressure natriuresis in mice lacking the AT2 receptor
2000 • 142 citations
AT 2 Receptor Stimulation Enhances Antihypertensive Effect of AT 1 Receptor Antagonist in Hypertensive Rats
1999 • 142 citations
Subtype 2 of angiotensin II receptors controls pressure-natriuresis in rats.
1995 • 138 citations
Novel mechanism of hypertension revealed by cell-specific targeting of human angiotensinogen in transgenic mice
1999 • 134 citations
Stimulation of endothelial cell prostaglandin production by angiotensin peptides. Characterization of receptors.
1992 • 134 citations
Role of Angiotensin II–Regulated Apoptosis Through Distinct AT 1 and AT 2 Receptors in Neointimal Formation
2002 • 134 citations
Renin—angiotensin system
1992 • 125 citations
Evidence for the existence of renin in the heart.
1987 • 123 citations
Multiple Interactions Between the Renin-Angiotensin and the Kallikrein-Kinin Systems: Role of ACE Inhibition and AT1 Receptor Blockade
2002 • 121 citations
Activation of AT 2 Receptors by Endogenous Angiotensin II Is Involved in Flow-Induced Dilation in Rat Resistance Arteries
1999 • 118 citations
Rat proximal tubule cell line transformed with origin-defective SV40 DNA: autocrine ANG II feedback
1999 • 118 citations
Vascular Response to Angiotensin II Is Exaggerated through an Upregulation of AT1 Receptor in AT2 Knockout Mice
1999 • 118 citations
Molecular Cloning and Identification of -Acyl-D-glucosamine 2-Epimerase from Porcine Kidney as a Renin-binding Protein
1996 • 116 citations
Canine Ventricular Myocytes Possess a Renin-Angiotensin System That Is Upregulated With Heart Failure
2001 • 115 citations
Evidence for a Physiological Role of Angiotensin-(1-7) in the Control of Hydroelectrolyte Balance
1996 • 115 citations
Endogenous production of angiotensin II modulates rat proximal tubule transport.
1996 • 114 citations
Renin and angiotensinogen gene expression in maturing rat kidney
1988 • 112 citations
Human prorenin.
1991 • 108 citations
Immunolocalization of Subtype 2 Angiotensin II (AT 2 ) Receptor Protein in Rat Heart
1998 • 106 citations
In situ hybridization and immunohistochemistry of renal angiotensinogen in neonatal and adult rat kidneys
1995 • 106 citations
The cardiac renin–angiotensin system: novel signaling mechanisms related to cardiac growth and function
2000 • 104 citations
Specific prorenin/renin binding (ProBP) Identification and characterization of a novel membrane site
1996 • 102 citations
Vascular Angiotensin-Converting Enzyme Expression Regulates Local Angiotensin II
1997 • 99 citations
Vasopeptidase inhibition and Ang-(1-7) in the spontaneously hypertensive rat
2002 • 97 citations
Angiotensin-(1-7) Attenuates Vasoconstriction Evoked by Angiotensin II but Not by Noradrenaline in Man
2000 • 96 citations
Angiotensin II Relaxes Microvessels Via the AT 2 Receptor and Ca 2+ -Activated K + (BK Ca ) Channels
2001 • 91 citations
Role of AT 2 Receptors in the Cardioprotective Effect of AT 1 Antagonists in Mice
2002 • 90 citations
Production of angiotensins I and II at tissue sites in intact pigs
1992 • 85 citations
Evidence for the Existence of a Functional Cardiac Renin-Angiotensin System in Humans
1996 • 81 citations
Production of angiotensinogen and renin-like activity by rabbit proximal tubular cells in culture
1991 • 79 citations
Molecular biology of the angiotensin I converting enzyme: II. Structure-function. Gene polymorphism and clinical implications
1993 • 78 citations
Vascular Wall Renin-Angiotensin Pathway in Control of the Circulation
1984 • 77 citations
Identification of vascular renin-binding proteins by chemical cross-linking: inhibition of binding of renin by renin inhibitors.
1994 • 75 citations
Renin-Like Enzyme in the Adrenal Gland
1967 • 75 citations
Effect of changes in sodium or potassium balance, and nephrectomy, on adrenal renin and aldosterone concentrations.
1984 • 75 citations
Angiotensin stimulates bicarbonate transport and Na+/K+ ATPase in rat proximal straight tubules.
1991 • 74 citations
Increased renal vasodilator prostanoids prevent hypertension in mice lacking the angiotensin subtype-2 receptor
1999 • 73 citations
Expression of the angiotensinogen gene and localization of its protein in the human heart.
1992 • 72 citations
Multiple Growth Factors Modulate mRNA Expression of Angiotensin II Type-2 Receptor in R3T3 Cells
1995 • 72 citations
Increased Vasoconstrictor Response of the Mouse Lacking Angiotensin II Type 2 Receptor
1999 • 71 citations
Functional Reconstitution of the Angiotensin II Type 2 Receptor and G i Activation
2000 • 69 citations
Uptake and proteolytic activation of prorenin by cultured human endothelial cells
1999 • 68 citations
Alterations in prostaglandin production in spontaneously hypertensive rat smooth muscle cells.
1993 • 65 citations
Insulin and Insulin‐Like Growth Factors Induce Expression of Angiotensin Type‐2 Receptor in Vascular‐Smooth‐Muscle Cells
1996 • 64 citations
Renal Interstitial cGMP Mediates Natriuresis by Direct Tubule Mechanism
2001 • 60 citations
Locally Generated Angiotensin II in the Adrenal Gland Regulates Basal, Corticotropin-, and Potassium-Stimulated Aldosterone Secretion
1995 • 60 citations
Molecular characterization and chromosome localization of a human angiotensin II AT2 receptor gene highly expressed in fetal tissues.
1994 • 58 citations
Renin Regulation in Cultured Proximal Tubular Cells
1996 • 57 citations
Colocalization and release of angiotensin and renin in renal cortical cells
1992 • 56 citations
The adrenal renin-angiotensin system: a local hormonal regulator of aldosterone production
1996 • 55 citations
Kinins, Receptors, Kininases and Inhibitors Where Did They Lead Us?
2001 • 49 citations
Differential actions of angiotensin-(1-7) in the kidney
1998 • 49 citations
Renin Uptake by the Endothelium Mediates Vascular Angiotensin Formation
2001 • 49 citations
The myocardial intracellular renin-angiotensin system
1987 • 48 citations
Renal actions of angiotensin-(1-7)
1997 • 48 citations
Identification of vascular renin-binding proteins by chemical cross-linking
1994 • 44 citations
Control of Renal Function by Intrarenal Angiotensin II*
1983 • 43 citations
Mechanisms by which nephrectomy stimulates adrenal renin.
1986 • 43 citations
Angiotensin AT2Receptor Degradation Is Prevented by Ligand Occupation
1998 • 31 citations
Pressure Natriuresis in AT2 Receptor–Deficient Mice with L-NAME Hypertension
2003 • 30 citations
Effect of AT 2 Receptor on Expression of AT 1 and TGF-β Receptors in VSMCs from SHR
2002 • 29 citations
The effect of losartan on potassium-stimulated aldosterone secretion in vitro.
1994 • 26 citations
Exogenous and locally synthesized angiotensin II and glomerulosa cell functions.
1990 • 25 citations
Presence of cellular renin-angiotensin system in chromaffin cells of bovine adrenal medulla
2002 • 22 citations
[Evidence of a renin receptor on human mesangial cells: effects on PAI1 and cGMP].
1998 • 21 citations
Induction of angiotensin II subtype 2 receptor-mediated blood pressure regulation in synthetic diet-fed rats
2000 • 20 citations
Reninlike enzymes in human vasculature.
1990 • 19 citations
Enhanced adrenal renin and aldosterone biosynthesis during sodium restriction in TGR (mREN2)27
1994 • 12 citations
Renal Sensitivity to Angiotensin II in the Conscious Dog*
1987 • 5 citations
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