Expression and localization of CYP3A4 and CYP3A5 in human lung.

A comprehensive set of sequence analysis programs for the VAX

1984 • 14,824 citations

P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature

1996 • 2,895 citations

Cytochrome P-450 hPCN3, a Novel Cytochrome P-450 IIIA Gene Product That Is Differentially Expressed in Adult Human Liver

1989 • 480 citations

Studies on the expression and metabolic capabilities of human liver cytochrome P450IIIA5 (HLp3).

1990 • 402 citations

CYP3A gene expression in human gut epithelium

1994 • 367 citations

Human cytochromes P450: problems and prospects

1992 • 364 citations

Selective expression of cytochrome P450 CYP3A mRNAs in embryonic and adult human liver

1994 • 269 citations

Five of 12 forms of vaccinia virus-expressed human hepatic cytochrome P450 metabolically activate aflatoxin B1.

1990 • 236 citations

Identification of a polymorphically expressed member of the human cytochrome P-450III family.

1989 • 224 citations

Roles of individual human cytochrome P-450 enzymes in the bioactivation of benzo(a)pyrene, 7,8-dihydroxy-7,8-dihydrobenzo(a)pyrene, and other dihydrodiol derivatives of polycyclic aromatic hydrocarbons.

1989 • 221 citations

The CYP1A1 gene and cancer susceptibility

1993 • 210 citations

Catalytic activities of human liver cytochrome P-450 IIIA4 expressed in Saccharomyces cerevisiae

1990 • 207 citations

Regulation of human liver cytochromes P-450 in family 3A in primary and continuous culture of human hepatocytes

1993 • 182 citations

The role of 12 cDNA‐expressed human, rodent, and rabbit cytochromes P450 in the metabolism of benzo[a]pyrene and benzo[a]pyrene trans‐7, 8‐dihydrodiol

1994 • 167 citations

Human P450PCN1: Sequence, Chromosome Localization, and Direct Evidence through cDNA Expression That P450PCN1 Is Nifedipine Oxidase

1988 • 164 citations

Immunohistochemical localization of glutathione S-transferases in human lung.

1993 • 160 citations

Expression of cytochrome P450 3A in amphibian, rat, and human kidney

1992 • 149 citations

Smoking and peripheral type of cancer are related to high levels of pulmonary cytochrome P450IA in lung cancer patients

1991 • 139 citations

Molecular Cloning and Sequence Analysis of cDNA Containing the Entire Coding Region for Human Fetal Liver Cytochrome P-4501

1989 • 118 citations

Identification of a novel dexamethasone responsive enhancer in the human CYP3A5 gene and its activation in human and rat liver cells.

1996 • 103 citations

Expression of cytochrome P 450 3A enzymes in human lung: a combined RT-PCR and immunohistochemical analysis of normal tissue and lung tumours

1996 • 76 citations

Detection of human lung cytochromes P450 that are immunochemically related to cytochrome P450IIE1 and cytochrome P450IIIA

1992 • 68 citations

Cytochrome P450 in Human Fetal Liver: Significance and Fetal-Specific Expresson

1994 • 62 citations

The Catalytic Activity of Four Expressed Human Cytochrome P450s Towards Benzo[a]pyrene and the Isomers of Its Proximate Carcinogen

1993 • 57 citations

Procarcinogen activation by cytochrome P450 3A4 and 3A5 expressed in Escherichia coli and by human liver microsomes

1995 • 56 citations

Immunohistochemical localization of cytochrome P450 3A in human pulmonary carcinomas and normal bronchial tissue

1995 • 55 citations

Sequence of the 5′-Flanking Region of CYP3A5: Comparative Analysis with CYP3A4 and CYP3A7

1994 • 54 citations

Human cytochromes P450 expressed in Escherichia coli: production of specific antibodies

1996 • 51 citations

Short synthetic peptides exploited for reliable and specific targeting of antibodies to the C-termini of cytochrome P450 enzymes

1995 • 50 citations

Recombinant DNA approaches for the development of metabolic systems used in in vitro toxicology

1992 • 49 citations

The metabolism of 1-nitropyrene by human cytochromes P450

1990 • 36 citations

Metabolism of 5-methylchrysene and 6-methylchrysene by human hepatic and pulmonary cytochrome P450 enzymes.

1996 • 33 citations

Isolation of CYP3A5P cDNA from human liver: a reflection of a novel cytochrome P-450 pseudogene

1995 • 12 citations