Inducible Repair and the Two Forms of Tumour Hypoxia - Time for a Paradigm Shift

Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review.

1989 • 3,308 citations

The Histological Structure of Some Human Lung Cancers and the Possible Implications for Radiotherapy

1955 • 2,174 citations

The Concentration of Oxygen Dissolved in Tissues at the Time of Irradiation as a Factor in Radiotherapy

1953 • 2,102 citations

Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix.

1996 • 1,747 citations

Dose fractionation, dose rate and iso-effect relationships for normal tissue responses

1982 • 1,081 citations

Pretreatment oxygenation predicts radiation response in advanced squamous cell carcinoma of the head and neck

1996 • 930 citations

Quantifying regional hypoxia in human tumors with positron emission tomography of [18F]fluoromisonidazole: A pretherapy study of 37 patients

1996 • 563 citations

Inherent cellular radiosensitivity as a basic concept for human tumor radiotherapy

1981 • 530 citations

Evidence for acutely hypoxic cells in mouse tumours, and a possible mechanism of reoxygenation

1979 • 523 citations

A molecular theory of cell survival

1973 • 500 citations

Loss of local control with prolongation in radiotherapy

1992 • 490 citations

[Fractionation in radiotherapy].

1972 • 487 citations

Role of Oxygen in Modifying the Radiosensitivity of E. Coli B.

1956 • 389 citations

Fluctuations in red cell flux in tumor microvessels can lead to transient hypoxia and reoxygenation in tumor parenchyma.

1996 • 365 citations

Pimonidazole: A Novel Hypoxia Marker for Complementary Study of Tumor Hypoxia and Cell Proliferation in Cervical Carcinoma

1998 • 320 citations

Oxygen in Human Tumors: Correlations between Methods of Measurement and Response to Therapy: Summary of a Workshop Held November 19-20, 1992, at the National Cancer Institute, Bethesda, Maryland

1993 • 298 citations

The Response of Chinese Hamster V79 Cells to Low Radiation Doses: Evidence of Enhanced Sensitivity of the Whole Cell Population

1993 • 293 citations

Effects of intercellular contact on repair of radiation damage

1972 • 287 citations

Survey of radiosensitivity in a variety of human cell strains.

1980 • 271 citations

Acute hypoxia in tumors: Implications for modifiers of radiation effects

1986 • 267 citations

Tumor tissue oxygenation as evaluated by computerized-po2-histography

1990 • 255 citations

Hypersensitivity to very-low single radiation doses: Its relationship to the adaptive response and induced radioresistance

1996 • 244 citations

Influence of Oxygen Tension on X-Ray-Induced Chromosomal Damage in Ehrlich Ascites Tumor Cells Irradiated in Vitro and in Vivo

1959 • 232 citations

BIOCHEMICAL INVESTIGATION OF HUMAN TUMOURS IN VIVO WITH PHOSPHORUS-31 MAGNETIC RESONANCE SPECTROSCOPY

1986 • 187 citations

The predictive value of cell kinetic measurements in a European trial of accelerated fractionation in advanced head and neck tumors: An interim report

1990 • 187 citations

Reductive metabolism of the hypoxia marker pimonidazole is regulated by oxygen tension independent of the pyridine nucleotide redox state

1998 • 179 citations

Intercapillary Distance, Oxygen Tension and Local Recurrence in Cervix Cancer

1968 • 174 citations

Growth of human tumour cell colonies from biopsies using two soft-agar techniques

1978 • 172 citations

Renal Damage in the Mouse: The Response to Very Small Doses per Fraction

1988 • 164 citations

Fluorescence immunohistochemical detection of hypoxic cells in spheroids and tumours

1987 • 150 citations

TUMOUR CELL PROLIFERATION IN RELATION TO THE VASCULATURE

1979 • 143 citations

Threshold Hypoxia: Its Effect on the Survival of Mammalian Cells Irradiated at high and low dose-rates

1966 • 136 citations

Intrinsic radiosensitivity as a predictor of patient response to radiotherapy

1995 • 135 citations

Hypersensitivity of a Human Tumour Cell Line to Very Low Radiation Doses

1993 • 135 citations

The importance of the pre-irradiation breathing times of oxygen and carbogen (5% CO2: 95% O2) on the in vivo radiation response of a murine sarcoma

1977 • 128 citations

Low-Dose Hypersensitivity and Increased Radioresistance in a Panel of Human Tumor Cell Lines with Different Radiosensitivity

1996 • 120 citations

Initial Slope of Radiation Survival Curves Is Characteristic of the Origin of Primary and Established Cultures of Human Tumor Cells and Fibroblasts

1987 • 118 citations

Cell clones : manual of mammalian cell techniques

1985 • 113 citations

Accelerated radiotherapy with carbogen and nicotinamide (ARCON) for laryngeal cancer

1998 • 111 citations

A Posteffect of Oxygen in Irradiated Bacteria: A Submillisecond Fast Mixing Study

1973 • 106 citations

Hypoxic Cell Radiosensitizers: Comparative Tests of Some Electron Affinic Compounds Using Epidermal Cell Survival in Vivo

1974 • 104 citations

The Use of ‘Top-up’ Experiments to Investigate the Effect of Very Small Doses Per Fraction in Mouse Skin

1985 • 99 citations

2-Nitroimidazole (EF5) binding predicts radiation resistance in individual 9L s.c. tumors.

1996 • 99 citations

Microregional fluctuations in perfusion within human tumours detected using laser Doppler flowmetry

1996 • 89 citations

Current Status of Knowledge and Critical Issues in Tumor Oxygenation

1998 • 88 citations

Hypersensitive Response of Normal Human Lung Epithelial Cells at Low Radiation Doses

1994 • 87 citations

Magnetic resonance imaging techniques for monitoring changes in tumor oxygenation and blood flow

1998 • 85 citations

Might intrinsic radioresistance of human tumour cells be induced by radiation?

1996 • 85 citations

The Response of a Human Tumor Cell Line to Low Radiation Doses: Evidence of Enhanced Sensitivity

1994 • 83 citations

Radiosensitivity of Human Head and Neck Squamous Cell Carcinomas in Primary Culture and its Potential as a Predictive Assay of Tumor Radiocurability

1989 • 75 citations

Variation in Radiation Response of Mammalian Cells as a Function of Oxygen Tension

1973 • 72 citations

Proliferation kinetics of endothelial and tumour cells in three mouse mammary carcinomas

1982 • 69 citations

Underprediction of human skin erythema at low doses per fraction by the linear quadratic model

1996 • 65 citations

Tumour stem cells: the biological concept and its application in cancer treatment

1994 • 64 citations

Low-Dose Radiation Sensitivity and Induced Radioresistance to Cell Killing in HT-29 Cells Is Distinct from the "Adaptive Response" and Cannot Be Explained by a Subpopulation of Sensitive Cells

1997 • 63 citations

Studies with bromodeoxyuridine in head and neck cancer and accelerated radiotherapy

1995 • 63 citations

Fractionation schedules and a quadratic dose-effect relationship

1975 • 63 citations

New insights into factors influencing the clinically relevant oxygen enhancement ratio

1998 • 63 citations

Vasculature and microenvironmental gradients: the missing links in novel approaches to cancer therapy?

1998 • 55 citations

The Effect of Oxygen on Low-Dose Hypersensitivity and Increased Radioresistance in Chinese Hamster V79-379A Cells

1994 • 54 citations

Radiation survival of cells from spheroids grown in different oxygen concentrations.

1979 • 50 citations

Multiphasic Survival Response of a Radioresistant Lepidopteran Insect Cell Line

1984 • 48 citations

Effects of Oxygen on the Metabolism of Murine Tumors Using in Vivo Phosphorus-31 NMR

1987 • 48 citations

The Effect of Extreme Hypoxia and Glucose on the Repair of Potentially Lethal and Sublethal Radiation Damage by Mammalian Cells

1977 • 45 citations

Oxygenation and reoxygenation in 'sandwich' tumours.

1977 • 45 citations

The Effect of Hypoxia on the Repair of Sublethal Radiation Damage in Cultured Mammalian Cells

1972 • 44 citations

Effect of glucose and galactose on microcirculatory flow in normal and neoplastic tissues in rabbits.

1987 • 42 citations

Assessment of tumor energy and oxygenation status by bioluminescence, nuclear magnetic resonance spectroscopy, and cryospectrophotometry.

1990 • 42 citations

Rate of Death of Hypoxic Cells in Multicell Spheroids

1978 • 41 citations

Radiotherapy of the rhabdomyosarcoma R1H of the rat: Hyperfractionation—126 fractions applied within 6 weeks

1989 • 40 citations

Radiation Survival of Cells from Spheroids Grown in Different Oxygen Concentrations

1979 • 37 citations

31P NMR spectroscopy and HbO2 cryospectrophotometry in prediction of tumor radioresistance caused by hypoxia

1989 • 35 citations

Fluorescent markers for hypoxic cells

1991 • 34 citations

The acute in vitro and in vivo radiosensitivity of human lung tumour lines

1986 • 33 citations

The potential benefit from a perfect radiosensitizer and its dependence on reoxygenation

1982 • 32 citations

The Oxygen Requirement for Recovery in Split-dose Experiments withOedogonium

1968 • 31 citations

A Pial Window Model for the Intracranial Study of Human Glioma Microvascular Function

1995 • 30 citations

Tumour Oxygenation Assessed by Polarographic Needle Electrodes and Bioenergetic Status Measured by³¹P Magnetic Resonance Spectroscopy in Human Soft Tissue Tumours

1997 • 29 citations

Cellular and Molecular Repair of X-Ray-Induced Damage: Dependence on Oxygen Tension and Nutritional Status

1985 • 28 citations

Effects of 5-thio-D-glucose on cellular adenosine triphosphate levels and deoxyribonucleic acid rejoining hy hypoxic and aerobic Chinese hamster cells.

1980 • 27 citations

Inducible Repair and Intrinsic Radiosensitivity: A Complex but Predictable Relationship?

2000 • 26 citations

Superfractionation as a potential hypoxic cell radiosensitizer: prediction of an optimum dose per fraction

1999 • 26 citations

The in vitro radiosensitivity of human head and neck cancers

1998 • 25 citations

The influence of radiation on blood vessels and circulation. Chapter IV. Structural changes in blood vessels.

1974 • 23 citations

Repair of radiation induced damage—dependence on oxygen and energy status

1988 • 22 citations

Cell contact as a possible contribution to radiation resistance of some tumours

1972 • 22 citations

Bioluminescence and fluoroscopic imaging of tissue pH and metabolites in experimental brain tumors of cat

1992 • 21 citations

The effect of hypoxia on recovery of sublethal radiation damage in Vicia seedlings

1969 • 20 citations

Energy Status and Radiobiological Hypoxia at Specified Oxygen Concentrations

1993 • 20 citations

Energy status in the murine FSaII and MCaIV tumors under aerobic and hypoxic conditions: An in-vivo and in-vitro analysis

1992 • 18 citations

Hyperfractionation as an effective way of overcoming radioresistance

1998 • 15 citations

Radiation-resistant tumor cells may be more sensitive in vitro.

1972 • 13 citations

Reoxygenation associated radiosensitization after chronic hypoxia: Effect of temperature and oxygen tension

1992 • 9 citations

Energy Status Parameters, Hypoxia Fraction and Radiocurability Across Tumor Types

1995 • 8 citations

Development of Bioreductive Markers for Tumour Hypoxia

1995 • 8 citations

Can 31P magnetic resonance spectroscopy measurements of changes in experimental tumour metabolism be related to modification of oxygenation status?

1992 • 7 citations

Current Topics: Radiosensitive human cells at the crossroads, high split-dose recovery and diminished inducible response

1997 • 4 citations

[The frequency of recurrences and metastases of bladder cancer following a radical course of radiotherapy].

1992 • 1 citations

[Intratumoral and parametric administration of metronidazole in the radiotherapy of cancer of the cervix].

1989 • 1 citations

Survival of mammalian cells in confluent culture ("stationary phase") irradiated under aerobic and hypoxic conditions: its implications for radiotherapy.

1969 • 1 citations

Deleted Work

1955 • 0 citations