Identification of a novel class of central reward sites showing a delayed and cumulative response to opiate blockade

Enkephalin may mediate euphoria and drive-reduction reward

1977 • 450 citations

Physical Dependence of Opiate-Like Peptides

1976 • 219 citations

Opioids and rewarding brain stimulation

1978 • 139 citations

Enhanced analgesic effects of morphine after chronic administration of naloxone in the rat

1978 • 128 citations

Supersensitivity to opioids following the chronic blockade of endorphin action by naloxone

1979 • 109 citations

A rapid and inexpensive technique for assessing the reinforcing effects of opiate drugs

1979 • 108 citations

Morphine Enhances Lateral Hypothalamic Self-Stimulation in the Rat

1972 • 95 citations

Apparent independence of opiate reinforcement and electrical self-stimulation systems in rat brain

1977 • 91 citations

Naloxone reduces pressing for intracranial stimulation of sites in the periaqueductal gray area, accumbens nucleus, substantia nigra, and lateral hypothalamus

1979 • 79 citations

Dose- and time-dependent effects of narcotic analgesics on intracranial self-stimulation in the rat

1977 • 23 citations

Appetitive determinants of self-stimulation

1978 • 19 citations

Brain endorphins: possible mediators of pleasure and reward.

1978 • 16 citations