Inhibition of Human Immunodeficiency Virus Type 1 Replication In Vitro by the Bisheteroarylpiperzine Atevirdine (U-87201E) in Combination with Zidovudine or Didanosine

Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors

1984 • 6,841 citations

Crystal Structure at 3.5 Å Resolution of HIV-1 Reverse Transcriptase Complexed with an Inhibitor

1992 • 1,887 citations

HIV with Reduced Sensitivity to Zidovudine (AZT) Isolated During Prolonged Therapy

1989 • 1,574 citations

Potent and selective inhibition of HIV-1 replication in vitro by a novel series of TIBO derivatives

1990 • 749 citations

Inhibition of HIV-1 Replication by a Nonnucleoside Reverse Transcriptase Inhibitor

1990 • 740 citations

Human immunodeficiency virus type 1 mutants resistant to nonnucleoside inhibitors of reverse transcriptase arise in tissue culture.

1991 • 398 citations

Viral resistance to human immunodeficiency virus type 1-specific pyridinone reverse transcriptase inhibitors

1991 • 366 citations

Standardized peripheral blood mononuclear cell culture assay for determination of drug susceptibilities of clinical human immunodeficiency virus type 1 isolates. The RV-43 Study Group, the AIDS Clinical Trials Group Virology Committee Resistance Working Group

1993 • 296 citations

Pyridinone derivatives: specific human immunodeficiency virus type 1 reverse transcriptase inhibitors with antiviral activity.

1991 • 289 citations

Ribavirin Antagonizes the Effect of Azidothymidine on HIV Replication

1987 • 282 citations

Synergistic inhibition of human immunodeficiency virus in vitro by azidothymidine and recombinant alpha A interferon

1987 • 237 citations

Standardization of sensitive human immunodeficiency virus coculture procedures and establishment of a multicenter quality assurance program for the AIDS Clinical Trials Group. The NIH/NIAID/DAIDS/ACTG Virology Laboratories

1992 • 229 citations

Effect of stage of disease and drug dose on zidovudine susceptibilities of isolates of human immunodeficiency virus.

1990 • 204 citations

Isolation of drug-resistant variants of HIV-1 from patients on long-term zidovudine therapy

1989 • 181 citations

Zidovudine sensitivity of human immunodeficiency viruses from high-risk, symptom-free individuals during therapy

1990 • 180 citations

Ribavirin antagonizes inhibitory effects of pyrimidine 2',3'-dideoxynucleosides but enhances inhibitory effects of purine 2',3'-dideoxynucleosides on replication of human immunodeficiency virus in vitro

1987 • 167 citations

A mutation in reverse transcriptase of bis(heteroaryl)piperazine-resistant human immunodeficiency virus type 1 that confers increased sensitivity to other nonnucleoside inhibitors.

1993 • 163 citations

BI-RG-587 is active against zidovudine-resistant human immunodeficiency virus type 1 and synergistic with zidovudine

1991 • 161 citations

Use of evolutionary limitations of HIV-1 multidrug resistance to optimize therapy

1993 • 156 citations

Two-Drug Combinations of Zidovudine, Didanosine, and Recombinant Interferon- A Inhibit Replication of Zidovudine-Resistant Human Immunodeficiency Virus Type 1 Synergistically In Vitro

1991 • 131 citations

Inhibition of Human Immunodeficiency Virus Type I (HIV-I) Replication by the Dipyridodiazepinone BI-RG-587

1991 • 112 citations

Decreased In Vitro Susceptibility to Zidovudine of HIV Isolates Obtained from Patients with AIDS

1990 • 100 citations

Synergistic activity of granulocyte-macrophage colony-stimulating factor and 3'-azido-3'-deoxythymidine against human immunodeficiency virus in vitro

1987 • 87 citations

Anti-human immunodeficiency virus synergism by zidovudine (3'-azidothymidine) and didanosine (dideoxyinosine) contrasts with their additive inhibition of normal human marrow progenitor cells

1991 • 82 citations

Synergistic inhibition of human immunodeficiency virus type 1 and type 2 replication in vitro by castanospermine and 3'-azido-3'-deoxythymidine

1989 • 69 citations

Inhibition of human immunodeficiency virus in vitro by combinations of 3'-azido-3'-deoxythymidine and foscarnet

1989 • 66 citations

Synergistic inhibition of replication of human immunodeficiency virus type 1, including that of a zidovudine-resistant isolate, by zidovudine and 2',3'-dideoxycytidine in vitro

1992 • 63 citations

The binding of a novel bisheteroarylpiperazine mediates inhibition of human immunodeficiency virus type 1 reverse transcriptase.

1992 • 62 citations

Prevention of the spread of HIV-1 infection with nonnucleoside reverse transcriptase inhibitors

1992 • 61 citations

Synergistic Inhibition of Human Immunodeficiency Virus Type 1 (HIV-1) Replication In Vitro by Recombinant Soluble CD4 and 3'-Azido-3'-Deoxythymidine

1989 • 60 citations

pol mutations conferring zidovudine and didanosine resistance with different effects in vitro yield multiply resistant human immunodeficiency virus type 1 isolates in vivo

1993 • 59 citations

Synergistic inhibition of human immunodeficiency virus type 1 replication in vitro by two-drug and three-drug combinations of 3'-azido-3'-deoxythymidine, phosphonoformate, and 2',3'-dideoxythymidine

1991 • 44 citations

Combined Treatment of Symptomatic Human Immunodeficiency Virus Type 1 Infection with Native Interferon- and Zidovudine

1991 • 39 citations

COMBO: A New Approach to the Analysis of Drug Combinations in Vitro^a

1990 • 16 citations

Differential Alteration of the Anti-HIV-1 Effect of Phosphorothioate Oligonucleotide S-dC28 by AZT, Interferon-Alpha, and Dextran Sulfate

1991 • 8 citations