HuEP5C7 as a Humanized Monoclonal Anti-E/P-Selectin Neurovascular Protective Strategy in a Blinded Placebo-Controlled Trial of Nonhuman Primate Stroke

Leukocyte rolling and extravasation are severely compromised in P selectin-deficient mice

1993 • 1,058 citations

Cerebral protection in homozygous null ICAM-1 mice after middle cerebral artery occlusion. Role of neutrophil adhesion in the pathogenesis of stroke.

1996 • 521 citations

Use of anti-ICAM-1 therapy in ischemic stroke

2001 • 500 citations

Selfotel in Acute Ischemic Stroke

2000 • 329 citations

Neuronal Protection in Stroke by an sLe ^x -Glycosylated Complement Inhibitory Protein

1999 • 313 citations

Glycine Antagonist in Neuroprotection for Patients With Acute Stroke

2001 • 275 citations

Reduced microvascular thrombosis and improved outcome in acute murine stroke by inhibiting GP IIb/IIIa receptor-mediated platelet aggregation.

1998 • 237 citations

Procedural and Strain-related Variables Significantly Affect Outcome in a Murine Model of Focal Cerebral Ischemia

1996 • 220 citations

Mice Deficient in Mac-1 (CD11b/CD18) Are Less Susceptible to Cerebral Ischemia/Reperfusion Injury

1999 • 216 citations

Enhancement by the complement membrane attack complex of tumor necrosis factor-alpha-induced endothelial cell expression of E-selectin and ICAM-1.

1995 • 214 citations

Inhibition of in vivo lymphocyte migration to inflammation and homing to lymphoid tissues by the TA-2 monoclonal antibody. A likely role for VLA-4 in vivo.

1991 • 211 citations

The role of inflammation after acute stroke

1998 • 204 citations

Exacerbation of Cerebral Injury in Mice That Express the P-Selectin Gene

1997 • 198 citations

CD18-Mediated Neutrophil Recruitment Contributes to the Pathogenesis of Reperfused but Not Nonreperfused Stroke

1999 • 178 citations

Very Early Nimodipine Use in Stroke (VENUS)

2001 • 172 citations

The expression of P- and E-selectins in three models of middle cerebral artery occlusion

1998 • 162 citations

Antibody to the α4 Integrin Decreases Infarct Size in Transient Focal Cerebral Ischemia in Rats

2001 • 161 citations

The Role of the Complement Cascade in Ischemia/Reperfusion Injury: Implications for Neuroprotection

2001 • 151 citations

Postischemic Cerebrovascular E-Selectin Expression Mediates Tissue Injury in Murine Stroke

2000 • 151 citations

E-Selectin Appears in Nonischemic Tissue During Experimental Focal Cerebral Ischemia

1996 • 139 citations

Anti-ICAM-1 Monoclonal Antibody R6.5 (Enlimomab) Promotes Activation of Neutrophils in Whole Blood

1999 • 125 citations

Increase in Surface Expression of ICAM-1, VCAM-1 and E-Selectin in Human Cerebromicrovascular Endothelial Cells Subjected to Ischemia-Like Insults

1997 • 110 citations

Chronic Reversible Cerebral Ischemia

1980 • 109 citations

P-selectin antibody reduces hemorrhage and infarct volume resulting from MCA occlusion in the rat

1998 • 83 citations

Why do all drugs work in animals but none in stroke patients ? 1 Drugs promoting cerebral blood flow

1995 • 75 citations

A Modified Transorbital Baboon Model of Reperfused Stroke

2000 • 70 citations

Trends and Future Developments in the Pharmacological Treatment of Acute Ischaemic Stroke

1997 • 69 citations

Anti-adhesion Therapy

1997 • 68 citations

MRI and Brainstem Auditory Evoked Potential Evidence of Eighth Cranial Nerve Involvement in Multiple Sclerosis

1997 • 66 citations

Targeted Inhibition of Intrinsic Coagulation Limits Cerebral Injury in Stroke without Increasing Intracerebral Hemorrhage

1999 • 64 citations

Humanization and Pharmacokinetics of a Monoclonal Antibody with Specificity for Both E- and P-Selectin

1998 • 43 citations

Antibodies cross-reactive with E- and P-selectin block both E- and P- selectin functions

1995 • 36 citations

Calculation of total molecular electronic energies from Correlation Weighting of Local Graph Invariants

1999 • 14 citations

Lack of an Increased Expression of the CD11b/CD18 Antigen on the Surface of Peripheral Blood Circulating Pool of Leukocytes in Patients with an Acute Neurological Ischemic Event

2001 • 1 citations