Bacteria as the cause of ulcerative colitis

DiarrheagenicEscherichia coli

1998 • 4,911 citations

Interleukin-10-deficient mice develop chronic enterocolitis

1993 • 4,225 citations

Oral bacteriotherapy as maintenance treatment in patients with chronic pouchitis: A double-blind, placebo-controlled trial

2000 • 1,505 citations

Prophylaxis of pouchitis onset with probiotic therapy: a double-blind, placebo-controlled trial

2003 • 1,139 citations

Non-pathogenic Escherichia coli versus mesalazine for the treatment of ulcerative colitis: a randomised trial

1999 • 1,106 citations

Diarrheagenic Escherichia coli

2016 • 1,058 citations

Short chain fatty acids in the human colon.

1981 • 1,037 citations

Tolerance exists towards resident intestinal flora but is broken in active inflammatory bowel disease (IBD)

1995 • 965 citations

Presence of adherent Escherichia coli strains in ileal mucosa of patients with Crohn's disease

1998 • 832 citations

Intestinal flora in health and disease

1984 • 826 citations

Probiotics inhibit enteropathogenicE. coliadherence in vitro by inducing intestinal mucin gene expression

1999 • 820 citations

AN EXPERIMENT TO DETERMINE THE ACTIVE THERAPEUTIC MOIETY OF SULPHASALAZINE

1977 • 815 citations

Double‐blind comparison of an oral Escherichia coli preparation and mesalazine in maintaining remission of ulcerative colitis

1997 • 780 citations

Lactobacillus species prevents colitis in interleukin 10 gene–deficient mice

1999 • 771 citations

Spontaneous development of inflammatory bowel disease in T cell receptor mutant mice

1993 • 732 citations

THE COLONIC EPITHELIUM IN ULCERATIVE COLITIS: AN ENERGY-DEFICIENCY DISEASE?

1980 • 678 citations

Impact on the composition of the faecal flora by a new probiotic preparation: preliminary data on maintenance treatment of patients with ulcerative colitis

1999 • 572 citations

INTENSIVE INTRAVENOUS REGIMEN FOR SEVERE ATTACKS OF ULCERATIVE COLITIS

1974 • 550 citations

The coming of age of probiotics

1995 • 548 citations

Mucosal antibodies in inflammatory bowel disease are directed against intestinal bacteria.

1996 • 437 citations

Mycobacterium paratuberculosis DNA in Crohn's disease tissue.

1992 • 379 citations

Tolerance towards resident intestinal flora in mice is abrogated in experimental colitis and restored by treatment with interleukin‐10 or antibodies to interleukin‐12

1996 • 358 citations

Promotion of IgA Immune Response in Patients with Crohn’s Disease by Oral Bacteriotherapy with <i>Lactobacillus GG</i>

1996 • 329 citations

The intestinal mucus layer from patients with inflammatory bowel disease harbors high numbers of bacteria compared with controls

1999 • 313 citations

The effects of Lactobacillus strains and oat fiber on methotrexate- induced enterocolitis in rats

1996 • 305 citations

Controlled trial of intravenous metronidazole as an adjunct to corticosteroids in severe ulcerative colitis.

1986 • 281 citations

T cell specificity and cross reactivity towards enterobacteria,Bacteroides,Bifidobacterium, and antigens from resident intestinal flora in humans

1999 • 261 citations

Hydrogen sulphide: a bacterial toxin in ulcerative colitis?

1996 • 258 citations

Sulfasalazine Revisited

1993 • 233 citations

Long-term treatment of ulcerative colitis with ciprofloxacin: A prospective, double-blind, placebo-controlled study

1998 • 232 citations

IL-4 is a differentiation factor for transforming growth factor-β secreting Th3 cells and oral administration of IL-4 enhances oral tolerance in experimental allergic encephalomyelitis

1998 • 218 citations

Induction and prevention of colonic inflammation in IL-2-deficient mice.

1997 • 204 citations

The Effect of Exogenous Administration ofLactobacillus reuteriR2LC and Oat Fiber on Acetic Acid-Induced Colitis in the Rat

1993 • 196 citations

Double blind controlled trial of oral vancomycin as adjunctive treatment in acute exacerbations of idiopathic colitis.

1985 • 177 citations

The efficacy of tobramycin in the treatment of ulcerative colitis

1990 • 168 citations

Intravenous tobramycin and metronidazole as an adjunct to corticosteroids in acute, severe ulcerative colitis.

1994 • 165 citations

Impairment of Bacterial Flora in Human Ulcerative Colitis and Experimental Colitis in the Rat

1993 • 153 citations

Genetics of inflammatory bowel disease.

1994 • 148 citations

The role of TGF-β in growth, differentiation, and maturation of B lymphocytes

1999 • 148 citations

Varying cecal bacterial loads influences colitis and gastritis in HLA-B27 transgenic rats

1999 • 134 citations

Adhesive Escherichia coli in inflammatory bowel disease and infective diarrhoea.

1988 • 131 citations

Unifying hypothesis for inflammatory bowel disease and associated colon cancer: sticking the pieces together with sugar

1996 • 110 citations

A prospective randomized controlled trial of oral ciprofloxacin in acute ulcerative colitis.

1997 • 107 citations

Responses to self and non-self intestinal microflora in health and inflammatory bowel disease

1997 • 91 citations

Oral tolerance in disease

1999 • 88 citations

Frequency of pathogenic and enteroadherent Escherichia coli in patients with inflammatory bowel disease and controls.

1997 • 80 citations

Microbial factors in chronic intestinal inflammation

1996 • 77 citations

The pathogenic role of Bacteroides vulgatus in patients with ulcerative colitis.

1995 • 74 citations

Ueber die Grundlagen einer neuen ursächlichen Bekämpfung der pathologischen Darmflora¹)

1916 • 70 citations

Prevalence of enteropathogenic bacteria in surgically treated chronic inflammatory bowel disease.

1998 • 69 citations

Absence of Escherichia coli, Listeria monocytogenes, and Klebsiella pneumoniae antigens within inflammatory bowel disease tissues

1998 • 66 citations

Ulcerative colitis and Escherichia coli with adhesive properties.

1987 • 63 citations

Prophylaxis of pouchitis onset with probiotic therapy: A double-blind, placebo controlled trial

2000 • 62 citations

Comparison of Bacteroides vulgatus strains in the enhancement of experimental ulcerative colitis

1987 • 45 citations

Continuous feeding of Lactobacillus plantarum attenuates established colitis in interleukin-10 deficient mice

1998 • 39 citations

Ulcerative Disease of the Colon in Laboratory Animals Induced by Pepsin Inhibitors

1974 • 37 citations

Mucosally associated bacterial flora of the human colon: quantitative and species specific differences between normal and inflamed colonic biopsies

1999 • 36 citations

Incidence and activities of sulphate reducing bacteria in patients with ulcerative colitis

1995 • 24 citations

Helicobacter pylori: From art to a science

1998 • 20 citations

Mucosal tolerance

1999 • 8 citations