Neurobiology of Nicotine Addiction: Implications for Smoking Cessation Treatment

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Presynaptic nicotinic ACh receptors

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Acetylcholine receptors containing the β2 subunit are involved in the reinforcing properties of nicotine

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Varenicline: An α4β2 Nicotinic Receptor Partial Agonist for Smoking Cessation

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The mesolimbic dopaminergic system is implicated in the reinforcing effects of nicotine

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Nicotine Activation of α4* Receptors: Sufficient for Reward, Tolerance, and Sensitization

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Dramatic decreases in brain reward function during nicotine withdrawal

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Molecular and Cellular Aspects of Nicotine Abuse

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Pharmacology of Nicotine: Addiction and Therapeutics

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Nicotine reinforcement and cognition restored by targeted expression of nicotinic receptors

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Bupropion is a nicotinic antagonist.

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Cellular mechanisms of nicotine addiction

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Nicotine Medications for Smoking Cessation

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Cigarette Smoking Saturates Brain α4β2 Nicotinic Acetylcholine Receptors

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Operant responding for a visual reinforcer in rats is enhanced by noncontingent nicotine: implications for nicotine self-administration and reinforcement

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Epidemiology of Tobacco Use and Dependence

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1992 • 239 citations

The Selective α7 Nicotinic Acetylcholine Receptor Agonist PNU-282987 [N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]-4-chlorobenzamide Hydrochloride] Enhances GABAergic Synaptic Activity in Brain Slices and Restores Auditory Gating Deficits in Anesthetized Rats

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Smoking cessation among self-quitters.

1992 • 201 citations

Functional brain imaging of tobacco use and dependence

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AR-R 17779, an α7 nicotinic agonist, improves learning and memory in rats

1999 • 195 citations

NICOTINE ADDICTION

1999 • 193 citations

Nicotine serves as an effective reinforcer of intravenous drug-taking behavior in human cigarette smokers

2004 • 183 citations

Desensitized nicotinic receptors in brain

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Smoking Relapse during the First Year after Treatment for Early-Stage Non–Small-Cell Lung Cancer

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Update on Pharmacologic Options for Smoking Cessation Treatment

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Role of nicotine dose and sensory cues in the regulation of smoke intake

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Nicotine renal excretion rate influences nicotine intake during cigarette smoking.

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Conditioned Nicotine Withdrawal Profoundly Decreases the Activity of Brain Reward Systems

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Repeated nicotine exposure enhances responding with conditioned reinforcement

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Clinical significance of tobacco withdrawal

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Is Clonidine an Effective Smoking Cessation Therapy?

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Smoking cessation following admission to a coronary care unit

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Nonpharmacologic Therapy for Smoking Cessation: Characteristics and Efficacy of Current Approaches

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Desensitized nicotinic receptors in brain.

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Smoking habits after laryngectomy.

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