Basophil Responses to Chemokines Are Regulated by Both Sequential and Cooperative Receptor Signaling

G-protein-coupled receptor heterodimerization modulates receptor function

1999 • 1,146 citations

The chemokine receptor CCR4 in vascular recognition by cutaneous but not intestinal memory T cells

1999 • 839 citations

Eotaxin: a potent eosinophil chemoattractant cytokine detected in a guinea pig model of allergic airways inflammation.

1994 • 822 citations

Modulation of multiple neutrophil functions by preparative methods or trace concentrations of bacterial lipopolysaccharide.

1985 • 796 citations

Molecular cloning and characterization of a human eotaxin receptor expressed selectively on eosinophils.

1996 • 626 citations

Cloning, expression, and characterization of the human eosinophil eotaxin receptor.

1996 • 561 citations

Targeted Disruption of the Chemokine Eotaxin Partially Reduces Antigen-induced Tissue Eosinophilia

1997 • 537 citations

High expression of the chemokine receptor CCR3 in human blood basophils. Role in activation by eotaxin, MCP-4, and other chemokines.

1997 • 489 citations

Dendritic cell ontogeny: A human dendritic cell lineage of myeloid origin

1997 • 482 citations

Chemokine receptor usage by human eosinophils. The importance of CCR3 demonstrated using an antagonistic monoclonal antibody.

1997 • 474 citations

IL-18, although antiallergic when administered with IL-12, stimulates IL-4 and histamine release by basophils

1999 • 435 citations

Eosinophil Chemotactic Chemokines (Eotaxin, Eotaxin-2, RANTES, Monocyte Chemoattractant Protein-3 (MCP-3), and MCP-4), and C-C Chemokine Receptor 3 Expression in Bronchial Biopsies from Atopic and Nonatopic (Intrinsic) Asthmatics

1999 • 415 citations

Eotaxin-2, a Novel CC Chemokine that Is Selective for the Chemokine Receptor CCR3, and Acts Like Eotaxin on Human Eosinophil and Basophil Leukocytes

1997 • 413 citations

Monocyte chemotactic protein 3 is a most effective basophil- and eosinophil-activating chemokine.

1994 • 342 citations

The kinetics of chemotactic peptide-induced change in F-actin content, F-actin distribution, and the shape of neutrophils.

1985 • 319 citations

Human monocyte chemoattractant protein (MCP)-4 is a novel CC chemokine with activities on monocytes, eosinophils, and basophils induced in allergic and nonallergic inflammation that signals through the CC chemokine receptors (CCR)-2 and -3.

1996 • 314 citations

Cell-Mediated Damage to Helminths

1985 • 289 citations

A Key Role for Cc Chemokine Receptor 4 in Lipopolysaccharide-Induced Endotoxic Shock

2000 • 275 citations

Molecular Cloning and Functional Expression of a Novel CC Chemokine Receptor cDNA from a Human Basophilic Cell Line

1995 • 267 citations

Chemokines regulate cellular polarization and adhesion receptor redistribution during lymphocyte interaction with endothelium and extracellular matrix. Involvement of cAMP signaling pathway.

1995 • 265 citations

Kinetics of Eotaxin Generation and Its Relationship to Eosinophil Accumulation in Allergic Airways Disease: Analysis in a Guinea Pig Model In Vivo

1997 • 255 citations

CUTANEOUS BASOPHIL HYPERSENSITIVITY

1970 • 245 citations

Costimulation of T Cell Activation by Integrin-associated Protein (CD47) Is an Adhesion-dependent, CD28-independent Signaling Pathway

1997 • 236 citations

The chemokine monocyte chemoattractant protein-1 induces functional responses through dimerization of its receptor CCR2

1999 • 229 citations

C-C Chemokines in Allergen-Induced Late-Phase Cutaneous Responses in Atopic Subjects: Association of Eotaxin with Early 6-Hour Eosinophils, and of Eotaxin-2 and Monocyte Chemoattractant Protein-4 with the Later 24-Hour Tissue Eosinophilia, and Relationship to Basophils and Other C-C Chemokines (Monocyte Chemoattractant Protein-3 and RANTES)

1999 • 226 citations

Monocyte chemotactic protein 1 is a potent activator of human basophils.

1992 • 218 citations

RANTES and related chemokines activate human basophil granulocytes through different G protein‐coupled receptors

1993 • 216 citations

Molecular Cloning of a Novel Human CC Chemokine (Eotaxin-3) That Is a Functional Ligand of CC Chemokine Receptor 3

1999 • 208 citations

Interleukin 3 activates human blood basophils via high-affinity binding sites.

1989 • 202 citations

Basophils, eosinophils, and mast cells in atopic and nonatopic asthma and in late-phase allergic reactions in the lung and skin

2000 • 198 citations

RANTES, a monocyte and T lymphocyte chemotactic cytokine releases histamine from human basophils.

1992 • 187 citations

Production of the novel C-C chemokine MCP-4 by airway cells and comparison of its biological activity to other C-C chemokines.

1997 • 183 citations

Differential Regulation of Eosinophil Chemokine Signaling Via CCR3 and Non-CCR3 Pathways

1999 • 173 citations

Ablation of immunity to Amblyomma americanum by anti-basophil serum: cooperation between basophils and eosinophils in expression of immunity to ectoparasites (ticks) in guinea pigs.

1982 • 170 citations

Interleukin-18 (IL-18), although anti-allergic when administered with IL-12, stimulates IL-4 and histamine release by basophils

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The CXC-Chemokine Neutrophil-Activating Peptide-2 Induces Two Distinct Optima of Neutrophil Chemotaxis by Differential Interaction With Interleukin-8 Receptors CXCR-1 and CXCR-2

1997 • 127 citations

Shape changes, exocytosis, and cytosolic free calcium changes in stimulated human eosinophils.

1991 • 121 citations

Relationship of F-actin distribution to development of polar shape in human polymorphonuclear neutrophils

1992 • 118 citations

Recombinant human eotaxin induces oxygen radical production, Ca(2+)- mobilization, actin reorganization, and CD11b upregulation in human eosinophils via a pertussis toxin-sensitive heterotrimeric guanine nucleotide-binding protein

1996 • 111 citations

Monocyte chemotactic protein MCP-2 activates human basophil and eosinophil leukocytes similar to MCP-3.

1995 • 107 citations

Chemoattractant cross-desensitization of the human neutrophil IL-8 receptor involves receptor internalization and differential receptor subtype regulation.

1997 • 106 citations

Eotaxin Is a Potent Chemotaxin for Human Basophils

1997 • 105 citations

Cellular polarization induced by chemokines: a mechanism for leukocyte recruitment?

1996 • 104 citations

Regulation of cytokine expression and leukotriene formation in human basophils by growth factors, chemokines and chemotactic agonists

1999 • 99 citations

Degranulation of Basophilic Leukocytes in Allergic Contact Dermatitis Reactions in Man

1976 • 94 citations

Cutaneous basophil hypersensitivity. 3. Participation of the basophil in hypersensitivity to antigen-antibody complexes, delayed hypersensitivity and contact allergy. Passive transfer.

1971 • 93 citations

Activation of human basophils through the IL-8 receptor.

1992 • 82 citations

Cloning and Characterization of the Guinea Pig Eosinophil Eotaxin Receptor, C-C Chemokine Receptor-3: Blockade Using a Monoclonal Antibody In Vivo

1998 • 74 citations

Regulation of the Function of Eosinophils and Basophils

1997 • 67 citations

Novel technique for the direct flow cytofluorometric analysis of human basophils in unseparated blood and bone marrow, and the characterization of phenotype and peroxidase of human basophils

1999 • 65 citations

Antibody-Mediated Basophil Accumulations in Cutaneous Hypersensitivity Reactions of Guinea Pigs

1976 • 62 citations

Accumulation of basophils and their chemotactic activity in the airways during natural airway narrowing in asthmatic individuals.

1994 • 61 citations

Cutaneous Basophil Hypersensitivity

1971 • 52 citations

A Newly Described Activity of Guinea Pig IgG1 Antibodies: Transfer of Cutaneous Basophil Reactions

1978 • 45 citations

Cutaneous Basophil Hypersensitivity Uncovered in the Cell Transfer of Classical Tuberculin Hypersensitivity

1976 • 44 citations

Differential response of human basophils and mast cells to recombinant chemokines

1995 • 40 citations

A Flow Cytometric Method to Measure Shape Change of Human Neutrophils

1995 • 29 citations

Antibody-Mediated Basophil Accumulations in Cutaneous Hypersensitivity Reactions of Guinea Pigs

1976 • 27 citations

RANTES is a pro-inflammatory chemokine and chemoattracts basophil cells to extravascular sites

1997 • 23 citations

The role of basophils and mast cells in acute and late reactions in the skin

1997 • 23 citations

IgE antibody-mediated cutaneous basophil hypersensitivity reactions in guinea pigs.

1983 • 22 citations

Mast Cell and Basophil Number in the Airway Correlate with the Bronchial Responsiveness of Asthmatics

1995 • 22 citations

Local Transfer of Delayed Hypersensitivity and Cutaneous Basophil Hypersensitivity

1977 • 21 citations

Relationship between light scattering in flow cytometry and changes in shape, volume, and actin polymerization in human polymorphonuclear leukocytes

1995 • 19 citations

Simplified purification of human basophils

2000 • 19 citations

The CXC-Chemokine Neutrophil-Activating Peptide-2 Induces Two Distinct Optima of Neutrophil Chemotaxis by Differential Interaction With Interleukin-8 Receptors CXCR-1 and CXCR-2

1997 • 12 citations