Critical function of T cell death-associated gene 8 in glucocorticoid-induced thymocyte apoptosis

The Bcl-2 Protein Family: Arbiters of Cell Survival

1998 • 5,359 citations

Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation

1980 • 4,591 citations

BCL-2 family members and the mitochondria in apoptosis

1999 • 3,657 citations

Caspases: killer proteases

1997 • 2,440 citations

An APAF-1·Cytochrome c Multimeric Complex Is a Functional Apoptosome That Activates Procaspase-9

1999 • 2,088 citations

Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice

1996 • 1,902 citations

Reduced Apoptosis and Cytochrome c–Mediated Caspase Activation in Mice Lacking Caspase 9

1998 • 1,642 citations

Antitumor promotion and antiinflammation: Down-modulation of AP-1 (Fos/Jun) activity by glucocorticoid hormone

1990 • 1,605 citations

Transcriptional interference between c-Jun and the glucocorticoid receptor: Mutual inhibition of DNA binding due to direct protein-protein interaction

1990 • 1,583 citations

Glucocorticoid activation of a calcium-dependent endonuclease in thymocyte nuclei leads to cell death.

1984 • 1,441 citations

Differential Requirement for Caspase 9 in Apoptotic Pathways In Vivo

1998 • 1,292 citations

bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes

1991 • 1,223 citations

Apoptotic Pathways

1998 • 1,193 citations

Apaf1 Is Required for Mitochondrial Pathways of Apoptosis and Brain Development

1998 • 1,143 citations

DNA Binding of the Glucocorticoid Receptor Is Not Essential for Survival

1998 • 1,081 citations

Physical association and functional antagonism between the p65 subunit of transcription factor NF-kappa B and the glucocorticoid receptor.

1994 • 1,057 citations

Characterization of Mechanisms Involved in Transrepression of NF-κB by Activated Glucocorticoid Receptors

1995 • 815 citations

Glucocorticoids in T Cell Development and Function

2000 • 783 citations

Functional interactions between Stat5 and the glucocorticoid receptor

1996 • 681 citations

Interaction of CED-4 with CED-3 and CED-9: A Molecular Framework for Cell Death

1997 • 635 citations

Bcl-X _L interacts with Apaf-1 and inhibits Apaf-1-dependent caspase-9 activation

1998 • 534 citations

Caspase-9, Bcl-XL, and Apaf-1 Form a Ternary Complex

1998 • 523 citations

Negative cross-talk between RelA and the glucocorticoid receptor: a possible mechanism for the antiinflammatory action of glucocorticoids.

1995 • 487 citations

A New Dexamethasone-Induced Gene of the Leucine Zipper Family Protects T Lymphocytes from TCR/CD3-Activated Cell Death

1997 • 447 citations

Bcl-XL and Bcl-2 repress a common pathway of cell death.

1995 • 406 citations

New Twists in Gene Regulation by Glucocorticoid Receptor: Is DNA Binding Dispensable?

1998 • 330 citations

VDAC regulation by the Bcl-2 family of proteins

2000 • 323 citations

Glucocorticoid receptor-cAMP response element-binding protein interaction and the response of the phosphoenolpyruvate carboxykinase gene to glucocorticoids.

1993 • 306 citations

Identification of mRNAs Associated with Programmed Cell Death in Immature Thymocytes

1991 • 286 citations

Negative selection of CD4+CD8+ thymocytes by T cell receptor-induced apoptosis requires a costimulatory signal that can be provided by CD28.

1994 • 257 citations

Bclx regulates the survival of double-positive thymocytes.

1995 • 249 citations

STAT3 Acts as a Co-activator of Glucocorticoid Receptor Signaling

1997 • 236 citations

Dissection of thymocyte signaling pathways by in vivo expression of pertussis toxin ADP-ribosyltransferase.

1990 • 235 citations

Permeabilization of the mitochondrial inner membrane during apoptosis: impact of the adenine nucleotide translocator

2000 • 228 citations

Rescue of thymocytes and T cell hybridomas from glucocorticoid‐induced apoptosis by stimulation via the T cell receptor/CD3 complex: a possible in vitro model for positive selection of the T cell repertoire

1991 • 199 citations

A targeted glucocorticoid receptor antisense transgene increases thymocyte apoptosis and alters thymocyte development

1995 • 190 citations

Inhibition of thymocyte apoptosis and negative antigenic selection in bcl-2 transgenic mice.

1992 • 181 citations

Bcl-XL displays restricted distribution during T cell development and inhibits multiple forms of apoptosis but not clonal deletion in transgenic mice.

1995 • 178 citations

Glucocorticoid-induced apoptosis in the thymus.

1992 • 167 citations

Thymocyte Apoptosis Induced by T Cell Activation Is Mediated by Glucocorticoids In Vivo

2002 • 129 citations

T cells from baxalpha transgenic mice show accelerated apoptosis in response to stimuli but do not show restored DNA damage-induced cell death in the absence of p53.

1996 • 128 citations

Thymocyte apoptosis induced by elevated endogenous corticosterone levels

1994 • 126 citations

Developmental regulation of lck gene expression in T lymphocytes.

1991 • 124 citations

Identification of a Putative G Protein-Coupled Receptor Induced during Activation-Induced Apoptosis of T Cells

1996 • 109 citations

Isolation and Characterization of Glucocorticoid- and Cyclic AMP-Induced Genes in T Lymphocytes

1989 • 95 citations

Disruption of thymocyte development and lymphomagenesis induced by SV4O T-antigen

1990 • 91 citations

Genes Newly Identified as Regulated by Glucocorticoids in Murine Thymocytes

1991 • 91 citations

The T cell receptor repertoire of CD4-8+ thymocytes is altered by overexpression of the BCL-2 protooncogene in the thymus.

1994 • 76 citations

ATP depletion inhibits glucocorticoid-induced thymocyte apoptosis

1997 • 61 citations

Isolation of a cDNA clone, encoding a human β-galactoside binding protein, overexpressed during glucocorticoid-induced cell death

1991 • 60 citations

Tcl-30, a new T cell-specific gene expressed in immature glucocorticoid-sensitive thymocytes.

1992 • 27 citations

Studies of the mechanism of glucocorticoid-induced pyknosis in isolated rat thymocytes

1983 • 25 citations

[Molecular cloning and expression of a dexamethasone (DEX)-induced gene in mouse thymus].

1997 • 1 citations