Role of methylenetetrahydrofolate depletion in methotrexate-mediated intracellular thymidylate synthesis inhibition in cultured L1210 cells.

The Pharmacology and Clinical Use of Methotrexate

1983 • 769 citations

Enhanced inhibition of thymidylate synthase by methotrexate polyglutamates.

1985 • 330 citations

Inhibition of phosphoribosylaminoimidazolecarboxamide transformylase by methotrexate and dihydrofolic acid polyglutamates.

1985 • 312 citations

Thymidylate synthetase from amethopterin- resistant Lactobacillus casei

1971 • 228 citations

Folinic acid augmentation of the effects of fluoropyrimidines on murine and human leukemic cells.

1986 • 162 citations

THE BIOCHEMICAL, CELLULAR, AND PHARMACOLOGICAL ACTION AND EFFECTS OF THE FOLIC ACID ANTAGONISTS.

1963 • 156 citations

Polyglutamyl Derivatives of Folate as Substrates and Inhibitors of Thymidylate Synthetase

1974 • 145 citations

The effect of methotrexate on intracellular folate pools in human MCF-7 breast cancer cells. Evidence for direct inhibition of purine synthesis.

1986 • 140 citations

The effect of methotrexate on levels of dUTP in animal cells.

1980 • 128 citations

Biochemical determinants of 5-fluorouracil response in vivo. The role of deoxyuridylate pool expansion.

1975 • 121 citations

Folate metabolism in mammalian cells in culture. I Partial characterization of the folate derivatives present in L1210 mouse leukemia cells.

1976 • 116 citations

Interactions of pig liver methylenetetrahydrofolate reductase with methylenetetrahydropteroylpolyglutamate substrates and with dihydropteroylpolyglutamate inhibitors

1980 • 115 citations

The effects on 4-aminoantifolates on 5-formyltetrahydrofolate metabolism in L1210 cells. A biochemical basis of the selectivity of leucovorin rescue.

1987 • 83 citations

Role of thymidylate synthetase activity in development of methotrexate cytotoxicity.

1979 • 81 citations

Filter assay for thymidylate synthetase using 5-fluoro-2'-deoxyuridylate as an active site titrant

1974 • 80 citations

Rapid determination of thymidylate synthase activity and its inhibition in intact L1210 leukemia cells in vitro

1985 • 78 citations

Biological effects of folic acid antagonists with antineoplastic activity

1984 • 77 citations

Spectrophotometric studies on the combination of formaldehyde with tetrahydropteroylglutamic acid and other hydropteridines

1960 • 76 citations

Evaluation of ascorbic acid in protecting labile folic acid derivatives.

1983 • 75 citations

Inhibition of pig liver methylenetetrahydrofolate reductase by dihydrofolate: some mechanistic and regulatory implications

1979 • 60 citations

Analysis of folate cofactor levels in tissues using high-performance liquid chromatography

1983 • 58 citations

Effect of substrate analogs on the circular dichroic spectra of thymidylate synthetase from Lactobacillus casei

1975 • 54 citations

Comparison of folylpolyglutamate hydrolases of mouse liver, kidney, muscle and brain

1982 • 50 citations

Antifolate polyglutamylation and competitive drug displacement at dihydrofolate reductase as important elements in leucovorin rescue in L1210 cells.

1986 • 45 citations

[48] Tissue folate polyglutamate chain length determination by electrophoresis as thymidylate synthase-fluorodeoxyuridylate ternary complexes

1986 • 40 citations

Endogenous folate of normal fibroblasts using high-performance liquid chromatography and modified extraction procedure

1985 • 22 citations

Determination of mouse liver 5-methyltetrahydrofolate concentration and polyglutamate forms

1985 • 16 citations

Effects of methotrexate on folates in Krebs ascites and L1210 murine leukemia cells

1986 • 15 citations

Enzymatic Determination of Tissue Dihydrofolate

1984 • 12 citations

A radioenzymatic method for the determination of tissue 10-formyltetrahydrofolate

1986 • 11 citations