Interactions between the Werner Syndrome Helicase and DNA Polymerase δ Specifically Facilitate Copying of Tetraplex and Hairpin Structures of the d(CGG) Trinucleotide Repeat Sequence

Identification of a gene (FMR-1) containing a CGG repeat coincident with a breakpoint cluster region exhibiting length variation in fragile X syndrome

1991 • 3,422 citations

Variation of the CGG repeat at the fragile X site results in genetic instability: Resolution of the Sherman paradox

1991 • 2,062 citations

Formation of parallel four-stranded complexes by guanine-rich motifs in DNA and its implications for meiosis

1988 • 1,734 citations

Positional Cloning of the Werner's Syndrome Gene

1996 • 1,696 citations

Instability of a 550-Base Pair DNA Segment and Abnormal Methylation in Fragile X Syndrome

1991 • 1,482 citations

The Bloom's syndrome gene product is homologous to RecQ helicases

1995 • 1,371 citations

Monovalent cation-induced structure of telomeric DNA: The G-quartet model

1989 • 1,202 citations

A Review of its Symptomatology, Natural History, Pathologic Features, Genetics And Relationship to the Natural Aging Process

1966 • 831 citations

A sodium-potassium switch in the formation of four-stranded G4-DNA

1990 • 789 citations

The Werner syndrome protein is a DNA helicase

1997 • 597 citations

Trinucleotide repeats that expand in human disease form hairpin structures in vitro

1995 • 559 citations

Mutator phenotype of Werner syndrome is characterized by extensive deletions.

1989 • 417 citations

Werner's syndrome protein (WRN) migrates Holliday junctions and co‐localizes with RPA upon replication arrest

2000 • 385 citations

SGS1, a Homologue of the Bloom's and Werner's Syndrome Genes, Is Required for Maintenance of Genome Stability in Saccharomyces cerevisiae

1996 • 380 citations

Human Werner Syndrome DNA Helicase Unwinds Tetrahelical Structures of the Fragile X Syndrome Repeat Sequence d(CGG)

1999 • 362 citations

rqh1+, a fission yeast gene related to the Bloom's and Werner's syndrome genes, is required for reversible S phase arrest

1997 • 354 citations

Trinucleotide repeats affect DNA replication in vivo

1997 • 321 citations

The fragile X syndrome d(CGG)n nucleotide repeats form a stable tetrahelical structure.

1994 • 318 citations

Molecular Basis of Genetic Instability of Triplet Repeats

1996 • 310 citations

Functional and Physical Interaction between WRN Helicase and Human Replication Protein A

1999 • 302 citations

Werner Syndrome Protein

1998 • 268 citations

Cloning of Two New Human Helicase Genes of the RecQ Family: Biological Significance of Multiple Species in Higher Eukaryotes

1998 • 252 citations

CGG repeats associated with DNA instability and chromosome fragility form structures that block DNA synthesisin vitro

1995 • 240 citations

Positionally cloned human disease genes: Patterns of evolutionary conservation and functional motifs

1997 • 237 citations

Isolation and genetic characterization of a thymineless death-resistant mutant of Escherichia coli K12: Identification of a new mutation (recQ1) that blocks the RecF recombination pathway

1984 • 235 citations

Characterization of the Two Small Subunits of Saccharomyces cerevisiae DNA Polymerase δ

1998 • 221 citations

Hairpins are formed by the single DNA strands of the fragile X triplet repeats: structure and biological implications.

1995 • 220 citations

Characterization of Werner syndrome protein DNA helicase activity: Directionality, substrate dependence and stimulation by replication protein A

1998 • 208 citations

DNA helicase activity in Werner's syndrome gene product synthesized in a baculovirus system

1997 • 207 citations

Cloning and characterization of RECQL, a potential human homologue of the Escherichia coli DNA helicase RecQ.

1994 • 202 citations

Solution Structure of a DNA Quadruplex Containing the Fragile X Syndrome Triplet Repeat

1995 • 194 citations

Pausing of DNA Synthesis in Vitro at Specific Loci in CTG and CGG Triplet Repeats from Human Hereditary Disease Genes

1995 • 188 citations

Functional interaction between the Werner Syndrome protein and DNA polymerase δ

2000 • 187 citations

Comparative sequence analysis of ribonucleases HII, III, II PH and D

1997 • 183 citations

Structure and Processivity of Two Forms of Saccharomyces cerevisiae DNA Polymerase δ

1998 • 181 citations

Werner syndrome lymphoblastoid cells are sensitive to camptothecin-induced apoptosis in S-phase

1999 • 171 citations

A retarded rate of DNA replication and normal level of DNA repair in Werner's syndrome fibroblasts in culture

1977 • 161 citations

A putative nucleic acid-binding domain in Bloom's and Werner's syndrome helicases

1997 • 149 citations

Replication focus-forming activity 1 and the Werner syndrome gene product

1998 • 139 citations

Werner protein recruits DNA polymerase δ to the nucleolus

2000 • 129 citations

Unwinding of a DNA Triple Helix by the Werner and Bloom Syndrome Helicases

2001 • 117 citations

The Trinucleotide Repeat Sequence d(CGG)15 Forms a Heat-Stable Hairpin Containing Gsyn.cntdot.Ganti Base Pairs

1995 • 109 citations

The Fragile X Syndrome Single Strand d(CGG)n Nucleotide Repeats Readily Fold Back to Form Unimolecular Hairpin Structures

1995 • 106 citations

Evolution of the RECQ Family of Helicases: A Drosophila Homolog, Dmblm, Is Similar to the Human Bloom Syndrome Gene

1999 • 100 citations

WRN helicase expression in Werner syndrome cell lines

2000 • 91 citations

Molecular characterisation of RecQ homologues in Arabidopsis thaliana

2000 • 88 citations

Isolation and identification of the third subunit of mammalian DNA polymerase by PCNA-affinity chromatography of mouse FM3A cell extracts

1999 • 79 citations

Altered frequency of initiation sites of DNA replication in Werner's syndrome cells

1982 • 76 citations

Palindromes as Substrates for Multiple Pathways of Recombination in Escherichia coli

2000 • 76 citations

Prolongation of S phase and whole cell cycle in Werner's syndrome fibroblasts

1982 • 64 citations

Acid-facilitated Supramolecular Assembly of G-quadruplexes in d(CGG)β4

1995 • 44 citations

Tetrahelical Forms of the Fragile X Syndrome Expanded Sequence d(CGG) Are Destabilized by Two Heterogeneous Nuclear Ribonucleoprotein-related Telomeric DNA-binding Proteins

2000 • 40 citations

Over-representation of the disease associated (CAG) and (CGG) repeats in the human genome

1994 • 35 citations

A role for two DNA helicases in the replication of T4 bacteriophage DNA

1994 • 31 citations

New 5′-(CGG) -3′ Repeats in the Human Genome

1998 • 9 citations

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