Cachectic effects of recombinant human tumor necrosis factor in rats.

A SIMPLE METHOD FOR THE ISOLATION AND PURIFICATION OF TOTAL LIPIDES FROM ANIMAL TISSUES

1957 • 63,238 citations

Prognostic effect of weight loss prior tochemotherapy in cancer patients

1980 • 2,298 citations

Cachectin: More Than a Tumor Necrosis Factor

1987 • 1,457 citations

A generalized Kruskal-Wallis test for comparing K samples subject to unequal patterns of censorship

1970 • 1,384 citations

Starvation in Man

1970 • 1,242 citations

Tumors secreting human TNF/cachectin induce cachexia in mice

1987 • 634 citations

RAISED SERUM LEVELS OF TUMOUR NECROSIS FACTOR IN PARASITIC INFECTIONS

1986 • 469 citations

Cachectin/tumor necrosis factor exerts endocrine, paracrine, and autocrine control of inflammatory responses.

1988 • 441 citations

EVIDENCE FOR TUMOUR NECROSIS FACTOR/CACHECTIN PRODUCTION IN CANCER

1987 • 425 citations

THE IMMEDIATE CAUSES OF DEATH IN CANCER

1932 • 418 citations

Tumor necrosis factor and interleukin-1β: suppression of food intake by direct action in the central nervous system

1988 • 414 citations

Tumor necrosis factor and the acute metabolic response to tissue injury in man.

1988 • 300 citations

Bowel necrosis induced by tumor necrosis factor in rats is mediated by platelet-activating factor.

1988 • 300 citations

Uncomplicated starvation versus cancer cachexia.

1977 • 293 citations

Hypertriglyceridemia associated with Trypanosoma brucei brucei infection in rabbits: Role of defective triglyceride removal

1980 • 260 citations

Synergy between tumor necrosis factor and bacterial products causes hemorrhagic necrosis and lethal shock in normal mice.

1988 • 260 citations

Acute in vivo effects of human recombinant tumor necrosis factor.

1987 • 256 citations

Multiple effects of tumor necrosis factor on lipoprotein lipase in vivo.

1987 • 240 citations

Recombinant human tumor necrosis factor administered as a five-day continuous infusion in cancer patients: phase I toxicity and effects on lipid metabolism.

1988 • 217 citations

Tolerance to tumor necrosis factor in rats and the relationship to endotoxin tolerance and toxicity.

1988 • 199 citations

Recombinant tumor necrosis factor increases pulmonary vascular permeability independent of neutrophils.

1988 • 161 citations

Pathogenesis of cachexia in cancer.A review and a hypothesis

1972 • 141 citations

Development of partial tolerance to the gastrointestinal effects of high doses of recombinant tumor necrosis factor-alpha in rodents.

1987 • 132 citations

Detection of Tumour Necrosis Factor‐Like Cytotoxicity in Serum from Patients With Septicaemia but Not from Untreated Cancer Patients

1986 • 130 citations

Parabiotic transfer of cancer anorexia/cachexia in male rats.

1985 • 121 citations

Recombinant human tumor necrosis factor induces acute reductions in food intake and body weight in mice.

1988 • 119 citations

Regulation of lipoprotein lipase synthesis by recombinant tumor necrosis factor—The primary regulatory role of the hormone in 3T3-L1 adipocytes

1986 • 113 citations

Tumor necrosis factor can induce fever in rats without activating protein breakdown in muscle or lipolysis in adipose tissue.

1988 • 111 citations

Long-term vascular access in the rat: importance of asepsis

1981 • 86 citations

Nutrition and Cancer: Physiological Interrelationships

1985 • 86 citations

Cachectin/TNF Production in Experimental Burns and Pseudomonas Infection

1988 • 76 citations

Cachectin/tumor necrosis factor: a possible mediator of cancer anorexia in the rat.

1988 • 73 citations

Are the Catabolic Effects of Tumor Necrosis Factor Mediated by Glucocorticoids?

1990 • 63 citations

Tumor-Induced Anorexia in the Wistar Rat

1981 • 56 citations

Body composition changes in rats with experimental cancer cachexia: improvement with exogenous insulin.

1988 • 53 citations

Recombinant human tumor necrosis factor does not inhibit lipoprotein lipase in primary cultures of isolated human adipocytes

1988 • 48 citations