Renal cancer cells lacking hypoxia inducible factor (HIF)-1 expression maintain vascular endothelial growth factor expression through HIF-2

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2001 • 9,275 citations

Targeting HIF-1 for cancer therapy

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Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands.

1996 • 5,667 citations

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

1999 • 4,973 citations

Hypoxia — a key regulatory factor in tumour growth

2002 • 4,942 citations

A Randomized Trial of Bevacizumab, an Anti–Vascular Endothelial Growth Factor Antibody, for Metastatic Renal Cancer

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Regulation of angiogenesis by hypoxia: role of the HIF system

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High sensitivity mapping of methylated cytosines

1994 • 1,863 citations

Comprehensive analysis of CpG islands in human chromosomes 21 and 22

2002 • 1,485 citations

Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells.

1997 • 1,325 citations

Differential Roles of Hypoxia-Inducible Factor 1α (HIF-1α) and HIF-2α in Hypoxic Gene Regulation

2003 • 1,285 citations

The Expression and Distribution of the Hypoxia-Inducible Factors HIF-1α and HIF-2α in Normal Human Tissues, Cancers, and Tumor-Associated Macrophages

2000 • 1,272 citations

A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1α regulates the VEGF expression and is potentially involved in lung and vascular development

1997 • 1,004 citations

Contrasting Properties of Hypoxia-Inducible Factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-Associated Renal Cell Carcinoma

2005 • 907 citations

Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein

2002 • 754 citations

Induction of Endothelial PAS Domain Protein-1 by Hypoxia: Characterization and Comparison With Hypoxia-Inducible Factor-1α

1998 • 633 citations

Aberrant and Alternative Splicing in Cancer

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Inhibition of HIF2α Is Sufficient to Suppress pVHL-Defective Tumor Growth

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The contribution of VHL substrate binding and HIF1-α to the phenotype of VHL loss in renal cell carcinoma

2002 • 438 citations

Differentiating the functional role of hypoxia‐inducible factor (HIF)‐1α and HIF‐2α (EPAS‐1) by the use of RNA interference: erythropoietin is a HIF‐2α target gene in Hep3B and Kelly cells

2004 • 390 citations

Predominant role of hypoxia-inducible transcription factor (Hif)-1alpha versus Hif-2alpha in regulation of the transcriptional response to hypoxia.

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Constitutive activation of hypoxia-inducible genes related to overexpression of hypoxia-inducible factor-1alpha in clear cell renal carcinomas.

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Overproduction of Vascular Endothelial Growth Factor Related to von Hippel-Lindau Tumor Suppressor Gene Mutations and Hypoxia-Inducible Factor-1α Expression in Renal Cell Carcinomas.

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The Human Hypoxia-Inducible Factor 1α Gene:HIF1AStructure and Evolutionary Conservation

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Alternative splicing of human genes: more the rule than the exception?

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Identification of Alternative Spliced Variants of Human Hypoxia-inducible Factor-1α

2000 • 98 citations

A dominant-negative isoform lacking exons 11 and 12 of the human hypoxia-inducible factor-1α gene

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Nur77 Activated by Hypoxia-Inducible Factor-1α Overproduces Proopiomelanocortin in von Hippel-Lindau-Mutated Renal Cell Carcinoma

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Frequent Overexpression of Vascular Endothelial Growth Factor Gene in Human Renal Cell Carcinoma.

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Clinical significance of angiogenesis, proliferation and apoptosis in renal cell carcinoma.

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Prognostic importance of serum vascular endothelial growth factor in relation to platelet and leukocyte counts in human renal cell carcinoma

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Quantification by competitive quantitative RT-PCR of VEGF121 and VEGF165 in renal cell carcinoma.

1999 • 22 citations

Inhibition of the ubiquitin-proteasome pathway activates stress kinases and induces apoptosis in renal cancer cells

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1990 • 13 citations