Autoantibodies to the Thyrotropin Receptor

Glycoprotein Hormones: Structure and Function

1981 • 2,296 citations

Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes

1985 • 2,257 citations

Cloning of the gene and cDNA for mammalian β-adrenergic receptor and homology with rhodopsin

1986 • 1,264 citations

Culture of hormone-dependent functional epithelial cells from rat thyroids.

1980 • 959 citations

THYROID-STIMULATING IMMUNOGLOBULINS IN GRAVES' DISEASE

1974 • 565 citations

Purification of the human thyroid peroxidase and its identification as the microsomal antigen involved in autoimmune thyroid diseases

1985 • 364 citations

Primary structure of human thyroglobulin deduced from the sequence of its 8448-base complementary DNA

1987 • 321 citations

Familial Neonatal Transient Hypothyroidism Due to Maternal TSH-Binding Inhibitor Immunoglobulins

1980 • 314 citations

Detection and Properties of TSH-Binding Inhibitor Immunoglobulins in Patients with Graves’ Disease and Hashimoto’s Thyroiditis*

1978 • 296 citations

[29] Production and assay of antibodies to acetylcholine receptors

1981 • 277 citations

AN IMPROVED RADIORECEPTOR ASSAY FOR TSH RECEPTOR ANTIBODIES

1982 • 270 citations

Carbimazole and the Autoimmune Response in Graves' Disease

1980 • 269 citations

Fundamental difference between the molecular interactions of agonists and antagonists with the β-adrenergic receptor

1979 • 259 citations

Human Thyroid Adenyl Cyclase-Stimulating Activity in Immunoglobulin G of Patients with Graves' Disease

1976 • 240 citations

ANTI-THYROID PEROXIDASE ANTIBODY IN PATIENTS WITH AUTOIMMUNE THYROID DISEASE: POSSIBLE IDENTITY WITH ANTI-MICROSOMAL ANTIBODY

1985 • 203 citations

Characterization of a Circulating Subpopulation of Spontaneous Antitetanus Toxoid Antibody Producing B Cells Following in Vivo Booster Immunization

1979 • 201 citations

A RECEPTOR ASSAY FOR THE MEASUREMENT OF TSH RECEPTOR ANTIBODIES IN UNEXTRACTED SERUM

1984 • 184 citations

A New in Vitro Assay for Human Thyroid Stimulator Using Cultured Thyroid Cells: Effect of Sodium Chloride on Adenosine 3′,5′-Monophosphate Increase*

1982 • 183 citations

Biosynthesis of thyroid hormone: Basic and clinical aspects

1977 • 169 citations

Thyroid Peroxidase and Thyroxine Biosynthesis

1970 • 157 citations

THE THYROTROPHIN RECEPTOR IN GUINEA-PIG THYROID HOMOGENATE: INTERACTION WITH THE LONG-ACTING THYROID STIMULATOR

1974 • 151 citations

Humoral factors in the pathogenesis of Graves' disease.

1968 • 142 citations

Short-Term Antithyroid Drug Therapy for the Thyrotoxicosis of Graves's Disease

1977 • 133 citations

Correlation between Thyrotropin-Displacing Activity and Human Thyroid-Stimulating Activity by Immunoglobulins from Patients with Graves' Disease and Other Thyroid Disorders*

1979 • 127 citations

Detection of Autoantibodies to Thyroid Peroxidase in Autoimmune Thyroid Diseases by Micro-ELISA and Immunoblotting*

1986 • 123 citations

Clinical Experience with a Human Thyroid Cell Bioassary for Thyroid-Stimulating Immunoglobin *

1984 • 121 citations

Similar Effects of Thionamide Drugs and Perchlorate on Thyroid-Stimulating Immunoglobulins in Graves' Disease: Evidence against an Immunosuppressive Action of Thionamide Drugs

1984 • 119 citations

A radio-ligand receptor assay for the long-acting thyroid stimulator. Inhibition by the long-acting thyroid stimulator of the binding of radioiodinated thyroid-stimulating hormone to human thyroid membranes

1975 • 116 citations

Effects of Antithyroid Therapy on the Long-Acting Thyroid Stimulator and the Antithyroglobulin Antibodies¹

1969 • 109 citations

Inhibition of Thyrotropin-Induced Adenosine 3′5′-Monophosphate Increase by Immunoglobulins from Patients with Primary Myxedema*

1983 • 106 citations

Correlation between Thyroid Stimulators and 3,5,3′-Triiodothyronine Suppressibility in Patients during Treatment for Hyperthyroidism with Thionamide Drugs:Comparison of Assays by Thyroid-Stimulating and Thyrotropin-Displacing Activities*

1979 • 104 citations

PROGNOSIS OF HYPERTHYROIDISM TREATED BY ANTITHYROID DRUGS

1953 • 103 citations

Immunoprecipitation of the Insulin Receptor: A Sensitive Assay for Receptor Antibodies and a Specific Technique for Receptor Purification*

1979 • 97 citations

Blocking Type Antithyrotropin Receptor Antibody in Patients with Nongoitrous Hypothyroidism: Its Incidence and Characteristics of Action

1985 • 94 citations

Restrictions in the response to autologous thyroglobulin in the human.

1980 • 94 citations

The detection of human antibodies against cytoskeletal components

1984 • 94 citations

Prediction and Therapy of Intrauterine and Late-Onset Neonatal Hyperthyroidism*

1986 • 94 citations

EFFECTS OF RADIOIODINE ON THYROTROPHIN BINDING INHIBITING IMMUNOGLOBULINS IN GRAVES’DISEASE

1979 • 90 citations

QUANTITATIVE RADIOLOGICAL AND HISTOLOGICAL STUDIES OF THE THYMUS IN THYROID DISEASE

1967 • 86 citations

SURVIVAL TIME OF CIRCULATING LONG-ACTING THYROID STIMULATOR IN NEONATAL THYROTOXICOSIS: IMPLICATIONS FOR DIAGNOSIS AND THERAPY OF THE DISORDER

1965 • 86 citations

Studies on the Biosynthesis of Iodotyrosines: A Soluble Thyroidal Iodide-Peroxidase Tyrosine-Iodinase System

1962 • 85 citations

[27] Measurement of thyrotropin receptor antibodies

1981 • 83 citations

Graves’ IgG stimulation of continuously cultured rat thyroid cells: a sensitive and potentially useful clinical assay

1982 • 83 citations

Thyroid autoantibody synthesis by cultures of thyroid and peripheral blood lymphocytes. I. Lymphocyte markers and response to pokeweed mitogen.

1983 • 80 citations

The thyroid "microsomal" antibody revisited. Its paradoxical binding in vivo to the apical surface of the follicular epithelium.

1984 • 77 citations

Thyrotropin receptors in adipose tissue, retro-orbital tissue and lymphocytes

1978 • 73 citations

Thyrotropin Receptors on Bovine Thyroid Membranes Two Types with Different Affinities and Specificities*

1979 • 73 citations

COMPARISON BETWEEN THYROID STIMULATING AND TSH‐BINDING INHIBITING IMMUNOGLOBULINS OF GRAVES' DISEASE

1981 • 72 citations

Fluorescent antibody studies in human thyroiditis: auto-antibodies to an antigen of the thyroid colloid distinct from thyroglobulin.

1961 • 67 citations

Environmental Iodine Intake Affects the Response to Methimazole in Patients with Diffuse Toxic Goiter*

1985 • 66 citations

Mechanism of Action of Thioureylene Antithyroid Drugs: Factors Affecting Intrathyroidal Metabolism of Propylthiouracil and Methimazole in Rats*

1978 • 66 citations

THYROID STIMULATING ANTIBODIES: AN AID TO THE STRATEGY OF TREATMENT OF GRAVES' DISEASE?

1984 • 63 citations

Thyroid-stimulating antibody (TSab) detected in sera of Graves' patients using human thyroid cell cultures.

1980 • 63 citations

Immunohistochemical characterization of intrathyroid lymphocytes in Graves' disease

1984 • 62 citations

THE ASSAY OF GRAVES’IMMUNOGLOBULINS: A COMPARISON OF DIFFERENT METHODS

1983 • 61 citations

TSH RECEPTOR ANTIBODY SYNTHESIS BY THYROID LYMPHOCYTES

1986 • 60 citations

Subpopulations of thyroid autoantibody secreting lymphocytes in Graves' and Hashimoto thyroid glands.

1986 • 58 citations

INFLUENCE OF TREATMENT WITH RADIOIODINE AND PROPYLTHIORACIL ON THYROID STIMULATING IMMUNOGLOBULINS IN GRAVES' DISEASE

1980 • 57 citations

THE GEOGRAPHICAL DISTRIBUTION OF THYROTOXICOSIS IN ENGLAND ACCORDING TO THE PRESENCE OR ABSENCE OF TSH‐RECEPTOR ANTIBODIES

1985 • 56 citations

Analysis of thyrotropin receptors by photoaffinity labelling. Orientation of receptor subunits in the cell membrane

1985 • 54 citations

Blocking activity to action of thyroid stimulating hormone in serum from patients with primary hypothyroidism.

1984 • 54 citations

Relationships Among Immunoglobulin Markers in Graves' Disease*

1979 • 52 citations

Structural features of the autoantigens involved in thyroid autoimmune disease: The thyroid microsomal/microvillar antigen

1985 • 51 citations

The long‐acting thyroid stimulator

1966 • 51 citations

Structure-activity analysis of microsomal antigen/thyroid peroxidase

1987 • 47 citations

IgG SUBCLASS DISTRIBUTION OF THYROID AUTOANTIBODIES: A ‘FINGERPRINT’ OF AN INDIVIDUAL'S RESPONSE TO THYROGLOBULIN AND THYROID MICROSOMAL ANTIGEN

1987 • 47 citations

EFFECT OF IRRADIATION ON THYROID-AUTOANTIBODY PRODUCTION

1979 • 47 citations

The thyrotropin receptor and its role in Graves’ disease1

1985 • 47 citations

PRODUCTION OF NON‐STIMULATORY IMMUNOGLOBULINS THAT INHIBIT TSH BINDING IN Graves' DISEASE AFTER RADIOIODINE ADMINISTRATION

1982 • 47 citations

The interaction of thyroid‐stimulating antibodies with solubilised human thyrotrophin receptors

1977 • 45 citations

Presence of Antideoxyribonucleic Acid Antibody in Patients with Hyperthyroidism of Graves’ Disease*

1987 • 43 citations

Functionality of Thyroid-Stimulating Antibodies Assessed by Cryopreserved Human Thyroid Cell Bioassay*

1983 • 43 citations

THE ABILITY OF THE SERUM THYROTROPHIN RECEPTOR ANTIBODY (TRAb) INDEX AND HLA STATUS TO PREDICT LONG‐TERM REMISSION OF THYROTOXICOSIS FOLLOWING MEDICAL THERAPY FOR GRAVEs' DISEASE

1986 • 41 citations

Rapid and Easy Separation of the Subunits of Bovine and Human Glycoprotein Hormones by Use of High Performance Liquid Chromatography*

1984 • 41 citations

Precipitation of the thyrotropin receptor and identification of thyroid autoantigens using Graves' disease immunoglobulins.

1984 • 40 citations

Labelling and immunoprecipitation of thyroid microsomal antigen

1985 • 39 citations

Photoaffinity labelling of the TSH receptor on FRTL₅, cells

1987 • 38 citations

Anti-tubulin antibodies in autoimmune thyroid disorders.

1983 • 38 citations

CHARACTERIZATION OF TSH ANTAGONIST ACTIVITY IN THE SERUM OF PATIENTS WITH THYROID DISEASE

1986 • 37 citations

BIOASSAY OF THYROID‐STIMULATING IMMUNOGLOBULINS USING HUMAN THYROID CELL CULTURES: OPTIMIZATION AND CLINICAL ASSESSMENT

1983 • 36 citations

Juvenile Graves disease: Usefulness and limitations of thyrotropin receptor antibody determinations

1987 • 35 citations

Isolation and characterization of a cDNA clone for porcine thyroid peroxidase

1986 • 35 citations

AN ANALYSIS OF THYROTROPHIN RECEPTOR BINDING AND THYROID STIMULATING ACTIVITIES IN A SERIES OF Graves' SERA

1985 • 35 citations

THIOURACIL TREATMENT OF THYROTOXICOSIS

1946 • 34 citations

Relapse of Graves' disease after medical therapy: predictive value of thyroidal technetium-99m uptake and serum thyroid stimulating hormone receptor antibody levels.

1985 • 34 citations

The interaction of graves' IgG with the thyrotrophin receptor

1981 • 32 citations

The Effect of Carbimazole on Thyroid Autoantibody Synthesis by Thyroid Lymphocytes*

1985 • 31 citations

Evidence of a correlation between thyrotrophin receptor binding inhibition and thyroid adenylate cyclase activation by immunoglobulins in Graves' disease before and during long-term antithyroid treatment

1982 • 29 citations

Isoelectric Focusing of Thyroid-Stimulating Antibody of Graves' Disease*

1978 • 29 citations

Methodological Aspects and Clinical Results of an Assay for Thyroid-Stimulating Antibodies: Correlation with Thyrotropin Binding-Inhibiting Antibodies*

1984 • 25 citations

Radioreceptor assay of anti-TSH receptor antibody activity: comparison of assays using unextracted serum and immunoglobulin fractions, and standardization of expression of activities.

1986 • 25 citations

TSH RECEPTOR BINDING AND THYROID STIMULATION BY SERA FROM PATIENTS WITH GRAVES' DISEASE

1983 • 25 citations

A structural comparison of guinea pig thyroid and fat TSH receptors by photoaffinity labelling

1984 • 24 citations

Functional analysis of T and B cells from blood and thyroid tissue in Hashimoto's disease.

1985 • 23 citations

Affinity-labelling of the thyrotropin receptor. Characterization of the photoactive ligand

1985 • 22 citations

HETEROGENEITY OF LONG ACTING THYROID STIMULATING (LATS) – ACTIVITY, THYROGLOBULIN ANTIBODIES AND THYROID MICROSOMAL ANTIBODIES

1973 • 21 citations

A structure for the porcine TSH receptor

1985 • 20 citations

Relation Between Thyroid Iodine Content and the Accumulation and Oxidation of [³⁵S]Methimazole in the Rat

1975 • 18 citations

COMPARISON OF BINDING OF BOVINE AND HUMAN THYROID-STIMULATING HORMONE TO RECEPTOR SITES ON HUMAN THYROID MEMBRANES

1981 • 17 citations

IgG THYROTROPHIN RECEPTOR ANTIBODY ACTIVITY IN GRAVES' DISEASE; A STUDY OF TSH AGONIST AND ANTAGONIST ACTIVITIES BY ISOELECTRIC FOCUSING

1986 • 15 citations

TSH CROSSLINKS TO THE TSH RECEPTOR THROUGH THE β SUBUNIT

1985 • 14 citations

Isoelectric Focusing of Long-Acting Thyroid Stimulator Immunoglobulin G

1973 • 13 citations

Thyrotropin Receptor Antibodies

1981 • 13 citations

Thyrotropin cross-links to the thyrotropin receptor through both the α and β subunits

1986 • 13 citations

Treatment of Hyperthyroidism with Methylthiouracil.

1947 • 12 citations

Interaction of autoantibodies to thyrotropin receptor with a hydrophilic subunit of the thyrotropin receptor

1985 • 12 citations

Further studies on the covalent crosslinking of thyrotropin to its receptor: Evidence that both the α and β subunits of thyrotropin are crosslinked to the receptor

1987 • 12 citations

The TSH receptor: Structure and interaction with autoantibodies in thyroid disease

1987 • 11 citations

Assessment of the shape and molecular size of TSH-TSH receptor complexes

1986 • 11 citations

THYROID STIMULATION BY (FAB)₂ AND FAB FRAGMENTS OF TSH RECEPTOR ANTIBODY

1985 • 11 citations

Tyrosine residues of bovine thyrotropin. Accessibility to iodination in the intact hormone and isolated subunits.

1984 • 10 citations

Antibodies to membrane antigens in autoimmune thyroid disease

1987 • 10 citations

CONTROL OF THYREOTOXICOSIS BY METHYL THIOURACIL

1947 • 10 citations

Affinity Labelling of the Thyrotropin Receptor

1984 • 9 citations

The interaction between the TSH receptor and Graves' sera with TSH agonist or antagonist properties

1985 • 8 citations

PROTEIN‐A PURIFIED HUMAN IMMUNOGLOBULINS: A COMPARISON OF THYROID STIMULATING AND THYROTROPHIN RECEPTOR BINDING ACTIVITIES IN THYROTOXICOSIS

1986 • 8 citations

Five-year follow-up of thyrotoxicosis treated with antithyroid drugs.

1974 • 5 citations

Isoelectric focusing of the human TSH receptor A subunit

1986 • 5 citations

A Salt-Induced Reversible Co-operative Transition in the Pig Thyrotropin Receptor

1978 • 3 citations

The subunit structure of the thyrotropin receptor

1987 • 3 citations