Development of Large Scale Fractionation Methods

DISC ELECTROPHORESIS – II METHOD AND APPLICATION TO HUMAN SERUM PROTEINS*

1964 • 18,916 citations

Immunochemical quantitation of antigens by single radial immunodiffusion

1965 • 9,369 citations

A simplified method for cyanogen bromide activation of agarose for affinity chromatography

1974 • 1,951 citations

Preparation and Properties of Serum and Plasma Proteins. IV. A System for the Separation into Fractions of the Protein and Lipoprotein Components of Biological Tissues and Fluids^1a,b,c,d

1946 • 1,815 citations

The Purification and Mechanism of Action of Human Antithrombin-Heparin Cofactor

1973 • 1,363 citations

Isoelectric Fractionation, Analysis, and Characterization of Ampholytes in Natural pH Gradients. IV. Further Studies on the Resolving Power in Connection with Separation of Myoglobins.

1966 • 1,303 citations

Inherited Antithrombin Deficiency Causing Thrombophilia

1965 • 1,040 citations

The Partial Thromboplastin Time with Kaolin: A Simple Screening Test for First Stage Plasma Clotting Factor Deficiencies

1961 • 1,015 citations

The Control of Dicumarol Therapy and the Quantitative Determination of Prothrombin and Proconvertin

1951 • 695 citations

An apparatus for preparative temperature-regulated polyacrylamide gel electrophoresis

1964 • 603 citations

A System for the Separation of the Components of Human Blood: Quantitative Procedures for the Separation of the Protein Components of Human Plasma^1a,b,c

1950 • 532 citations

Hemagglutination Assay for Antigen and Antibody Associated with Viral Hepatitis

1970 • 489 citations

A rapid procedure for the estimation of amino sugars on a micro scale

1966 • 435 citations

Purification of antithrombin III by affinity chromatography

1974 • 426 citations

Production of High-Potency Concentrates of Antihemophilic Globulin in a Closed-Bag System

1965 • 426 citations

The Separation of the Antibodies, Isoagglutinins, Prothrombin, Plasminogen and β₁-Lipoprotein into Subfractions of Human Plasma

1949 • 412 citations

Two-stage Procedure For the Quantitative Determination of Prothrombin Concentration*

1949 • 379 citations

Heparin cofactor activity measured with an amidolytic method

1975 • 341 citations

HEPARIN-INDUCED DECREASE IN CIRCULATING ANTITHROMBIN-III

1977 • 295 citations

Familial Thrombosis Due to Antithrombin III Deficiency

1974 • 290 citations

Highly Purified Antithrombin III with Heparin Cofactor Activity Prepared by Disc Electrophoresis

1968 • 274 citations

The Specific Assay of Prower-Stuart Factor and Factor VII

1961 • 242 citations

Antithrombin III, Antifactor Xa and Heparin

1970 • 200 citations

Identity of Plasma-activated Factor X Inhibitor with Antithrombin III and Heparin Cofactor

1971 • 195 citations

Assay Methods and Standard Preparations for Plasmin, Plasminogen and Urokinase in Purified Systems, 1967-1968

1969 • 185 citations

Methods for the Production of Clinically Effective Intermediate and High‐Purity Factor‐VIII Concentrates

1971 • 181 citations

Immunelektrophoretischer Nachweis von ?Hepatitis-Associated-Antigen? (Au/SH-Antigen)

1970 • 170 citations

Purification of Two Progressive Antithrombins of Human Plasma

1967 • 145 citations

ORAL CONTRACEPTIVES, ANTITHROMBIN-III ACTIVITY, AND POSTOPERATIVE DEEP-VEIN THROMBOSIS

1976 • 144 citations

A Simple Two‐step Isolation Procedure for Human and Bovine Antithrombin II/III (Heparin Cofactor): a Comparison of Two Methods

1975 • 134 citations

EFFECT OF COMBINED ŒSTROGEN-PROGESTOGEN ORAL CONTRACEPTIVES, ŒSTROGEN, AND PROGESTOGEN ON ANTIPLASMIN AND ANTITHROMBIN ACTIVITY

1970 • 107 citations

Heparin-accelerated inhibition of activated factor X by its natural plasma inhibitor

1970 • 106 citations

ANTITHROMBIN-III TRANSFUSION IN DISSEMINATED INTRAVASCULAR COAGULATION

1978 • 105 citations

Antithrombin-III deficiency in a Dutch family

1973 • 102 citations

The direct photometric determination of aluminium with 8-hydroxyquinoline

1946 • 101 citations

Proteinase Inhibitors of Human Plasma

1971 • 97 citations

Treatment of Hemophilia B with a New Clotting-Factor Concentrate

1969 • 87 citations

Studies on the Antithrombin and Heparin Co-factor Activities of a Fraction Adsorbed from Plasma by Aluminum Hydroxide

1955 • 85 citations

A new high-potency glycine-precipitated antihemophilic factor (AHF) concentrate. Treatment of classical hemophilia and hemophilia with inhibitors.

1968 • 84 citations

Antithrombin III depression and thrombin generation acceleration in women taking oral contraceptives

1971 • 82 citations

Clinical Investigation of Intermediate‐ and High‐Purity Antihaemophilic Factor (Factor VIII) Concentrates

1971 • 77 citations

Decreased binding of heparin to antithrombin following the interaction between antithrombin and thrombin

1977 • 73 citations

Hereditary antithrombin iii deficiency and thromboembolic disease

1976 • 72 citations

Incomplete Inactivation of Hepatitis B Virus after Heat Treatment at 60 C for 10 Hours

1978 • 69 citations

The potent antihemophilic globulin concentrate derived from a cold insoluble fraction of human plasma: characterization and further data on preparation and clinical trial.

1966 • 67 citations

Fundamental Interactions and Effect of Storage, Ether, Adsorbants and Blood Clotting on Plasma Antithrombin Activity

1952 • 66 citations

A new two-stage functional assay for antithrombin-III (Heparin cofactor): Clinical and laboratory evaluation

1976 • 63 citations

[50] Glandular kallikreins from horse and human urine and from hog pancreas

1970 • 62 citations

THE COAGULATION DEFECT IN HEMOPHILIA: THE EFFECT, IN HEMOPHILIA, OF THE PARENTERAL ADMINISTRATION OF A FRACTION OF THE PLASMA GLOBULINS RICH IN FIBRINOGEN 123

1945 • 58 citations

Prothrombin Concentrates in Treatment of Christmas Disease and Allied Disorders

1969 • 57 citations

Preparation of a human plasma fraction rich in prothrombin, proconvertin, Stuart factor, and PTC and a study of its activity and toxicity in rabbits and man.

1959 • 54 citations

NEUTRALIZATION OF AUTOPROTHROMBIN C ACTIVITY WITH ANTITHROMBIN

1964 • 53 citations

Hemolytic Anemia Due to Anti‐A in Concentrated Antihemophilic Factor Preparations

1970 • 52 citations

ANTITHROMBIN III AND THE ŒSTROGEN CONTENT OF COMBINED ŒSTRO-PROGESTAGEN CONTRACEPTIVES

1972 • 51 citations

Inhibition of the Thrombin‐Fibrinogen Reaction by Heparin in the Absence of Cofactor

1968 • 48 citations

Inhibition of Autoprothrombin C Activity with Plasma

1962 • 46 citations

Heparin cofactor and plasma antithrombin in relation to the mechanism of inactivation of thrombin by heparin

1967 • 34 citations

Factor IX Concentrate and Viral Hepatitis

1971 • 34 citations

The Preparation for Therapeutic Use of a Concentrate of Factor IX Containing also Factors II, VII and X

1967 • 32 citations

Hemolysis Due to Anti-A and Anti-B in Factor VIII Preparations

1972 • 31 citations

Evaluation of a New Concentrate for the Treatment of Factor IX Deficiency

1969 • 28 citations

Purification of Hepatitis B Surface Antigen by Affinity Chromatography

1978 • 27 citations

Antithrombin III: Protection against Death after Injection of Thromboplastin

1969 • 25 citations

Electrophoretic Separation of Two Thrombin Inhibitors in Plasma and Serum

1969 • 25 citations

Familial Thrombosis Due to Antithrombin III Deficiency in a Greek Family

1977 • 25 citations

Paradoxical Bleeding in Intensively Transfused Hemophiliacs: Alteration of Platelet Function

1973 • 24 citations

Microheterogeneity of Human Antithrombin III

1978 • 23 citations

Two-stage procedure for the quantitative determination of autoprothrombin 3 concentration and some applications.

1967 • 22 citations

Development of Large-Scale Fractionation Methods

1972 • 21 citations

Chromatographic Behaviour of Clotting Factors

1969 • 20 citations

The Different Forms of Antithrombin III in Serum

1977 • 20 citations

Large scale preparation of nonthrombogenic prothrombin complex

1978 • 20 citations

Development of Large‐Scale Fractionation Methods

1978 • 19 citations

The separation of clotting factors II (prothrombin) and IX (plasma thromboplastin component) by isoelectric focusing.

1970 • 15 citations

INVESTIGATION OF EFFECT OF METAPHYSIAL TRAUMATISM ON MORPHOLOGY OF EPIPHYSIAL CARTILAGE IN RABBIT

1963 • 14 citations

Preparation and clinical use of factor IX concentrate PPSB according to Soulier.

1969 • 14 citations

Plasma Thromboplastin Component (PTC) Potency of Plasma Fractions.

1953 • 12 citations

Minimal Heparin Cofactor Activity in Disseminated Intravascular Coagulation and Cirrhosis

1976 • 12 citations

The Human Prothrombin-Activating Enzyme

1969 • 11 citations

Standardization of Factor VIII Preparations

1973 • 11 citations

Use of Frozen Cryoprecipitate for the Preparation of Clinical Factor VIII Concentrate

1973 • 11 citations

THE PREPARATION AND PROPERTIES OF A PROTHROMBIN COMPLEX (PPSB)

1969 • 10 citations

Human Antihemophilic Factor (AHF) Purification A Comparison of Two Procedures

1966 • 10 citations

NATURAL ŒSTROGENS AND ANTITHROMBIN-III LEVELS

1975 • 9 citations

Isolation of Human Antithrombin-III by Affinity Chromatography on Heparin-Agarose

1977 • 8 citations

Antihemophilic Factor: Its Presence in Fibrinogen, Assay Problems and the Stability of Lyophilized AHF-Fibrinogen Preparations

1963 • 6 citations

BLOOD GLOBULINS REDUCING THE ANTICOAGULANT ACTIVITY OF HEPARIN

1956 • 6 citations

Heparin insensitivity responding to fresh frozen plasma.

1978 • 6 citations

Treatment of congenital deficiencies of factor VIII and factor IX.

1968 • 4 citations

[Stabilization of the P. P. B. fraction].

1959 • 3 citations

IMMUNOELECTROPHORETIC QUANTITATION OF ANTITHROMBIN III:

1977 • 3 citations

Large Scale Method for the Isolation of Antithrombin III.

1977 • 1 citations