Pathobiological reactions of C‐fibre primary sensory neurones to peripheral nerve injury

Local effector functions of capsaicin-sensitive sensory nerve endings: Involvement of tachykinins, calcitonin gene-related peptide and other neuropeptides

1988 • 1,673 citations

Pharmacologically induced selective degeneration of chemosensitive primary sensory neurones

1977 • 1,284 citations

Substance P as neurogenic mediator of antidromic vasodilation and neurogenic plasma extravasation

1979 • 1,199 citations

The Axon Reaction: A Review of the Principal Features of Perikaryal Responses to Axon Injury

1971 • 1,112 citations

Calcitonin gene-related peptide immunoreactivity in the spinal cord of man and of eight other species

1984 • 1,024 citations

The neuropharmacology of capsaicin: review of some recent observations.

1986 • 833 citations

Conduction velocity is related to morphological cell type in rat dorsal root ganglion neurones.

1985 • 749 citations

Intrathecal morphine inhibits substance P release from mammalian spinal cord in vivo

1980 • 697 citations

Reexamination of the dorsal root projection to the spinal dorsal horn including observations on the differential termination of coarse and fine fibers

1979 • 465 citations

Neuropeptide expression in rat dorsal root ganglion cells and spinal cord after peripheral nerve injury with special reference to galanin

1989 • 460 citations

Substance P: Depletion in the dorsal horn of rat spinal cord after section of the peripheral processes of primary sensory neurons

1979 • 455 citations

Increase of galanin-like immunoreactivity in rat dorsal root ganglion cells after peripheral axotomy

1987 • 448 citations

The somatotopic organization of primary afferent terminals in the superficial laminae of the dorsal horn of the rat spinal cord

1985 • 446 citations

Distribution of calcitonin gene-related peptide in the rat peripheral nervous system with reference to its coexistence with substance P

1985 • 439 citations

Soma neurofilament immunoreactivity is related to cell size and fibre conduction velocity in rat primary sensory neurons.

1991 • 425 citations

Vasoactive intestinal polypeptide induces glycogenolysis in mouse cortical slices: a possible regulatory mechanism for the local control of energy metabolism.

1981 • 352 citations

The growth-associated protein gap-43 appears in dorsal root ganglion cells and in the dorsal horn of the rat spinal cord following peripheral nerve injury

1990 • 324 citations

Nerve growth factor protects adult sensory neurons from cell death and atrophy caused by nerve injury

1987 • 316 citations

Lactoseries carbohydrates specify subsets of dorsal root ganglion neurons projecting to the superficial dorsal horn of rat spinal cord

1985 • 315 citations

A monoclonal antibody against neurofilament protein specifically labels a subpopulation of rat sensory neurones

1984 • 306 citations

Death of some dorsal root ganglion neurons and plasticity of others following sciatic nerve section in adult and neonatal rats

1989 • 302 citations

Macrophage dependence of peripheral sensory nerve regeneration: Possible involvement of nerve growth factor

1991 • 296 citations

Plasticity in the spinal cord sensory map following peripheral nerve injury in rats

1981 • 291 citations

Pharmacological effects of nerve growth factor and fibroblast growth factor applied to the transectioned sciatic nerve on neuron death in adult rat dorsal root ganglia

1987 • 285 citations

Nerve growth factor counteracts the neurophysiological and neurochemical effects of chronic sciatic nerve section

1985 • 268 citations

Capsaicin applied to peripheral nerve inhibits axoplasmic transport of substance P and somatostatin

1982 • 250 citations

Expression of growth-associated protein B-50 (GAP43) in dorsal root ganglia and sciatic nerve during regenerative sprouting

1989 • 249 citations

Cell type and conduction velocity of rat primary sensory neurons with calcitonin gene-related peptide-like immunoreactivity

1990 • 242 citations

Peripheral patterns of calcitonin‐gene‐related peptide general somatic sensory innervation: Cutaneous and deep terminations

1989 • 229 citations

Cell loss in lumbar dorsal root ganglia and transganglionic degeneration after sciatic nerve resection in the rat

1986 • 224 citations

Expression of GAP-43, a rapidly transported growth-associated protein, and class II beta tubulin, a slowly transported cytoskeletal protein, are coordinated in regenerating neurons

1989 • 217 citations

Laminar distribution and somatotopic organization of primary afferent fibers from hindlimb nerves in the dorsal horn. A study by transganglionic transport of horseradish peroxidase in the rat

1986 • 200 citations

Vasoactive intestinal polypeptide (VIP) increases in the spinal cord after peripheral axotomy of the sciatic nerve originate from primary afferent neurons

1986 • 199 citations

Distribution of chemosensitive primary sensory afferents in the central nervous system of the rat

1980 • 189 citations

Monoclonal antibodies against carbohydrate differentiation antigens identify subsets of primary sensory neurones

1984 • 185 citations

Nerve cell degeneration and death in the trigeminal ganglion of the adult rat following peripheral nerve transection

1978 • 182 citations

The reaction of primary sensory neurons to peripheral nerve injury with particular emphasis on transganglionic changes

1985 • 174 citations

Mapping and plasticity of acid phosphatase afferents in the rat dorsal horn

1980 • 165 citations

Sir Thomas Lewis's nocifensor system, histamine and substance-P-containing primary afferent nerves

1983 • 157 citations

Histochemical localization of galactose-containing glycoconjugates in sensory neurons and their processes in the central and peripheral nervous system of the rat.

1985 • 155 citations

Capsaicin‐induced neuronal degeneration: Silver impregnation of cell bodies, axons, and terminals in the central nervous system of the adult rat

1988 • 154 citations

Direct evidence for an axonal site of action of capsaicin

1980 • 152 citations

Preterminal and terminal axon arborizations in the substantia gelatinosa of cat's spinal cord

1977 • 145 citations

The dorsal root distribution to the substantia gelatinosa of the rat with a note on the distribution in the cat

1968 • 144 citations

Transganglionic degeneration in trigeminal primary sensory neurons

1975 • 144 citations

Deafferentation in animals as a model for the study of pain: an alternative hypothesis

1984 • 143 citations

Prepro-VIP and preprotachykinin mRNAs in the rat dorsal root ganglion cells following peripheral axotomy

1989 • 141 citations

Neurotoxic effect of capsaicin in mammals.

1987 • 140 citations

The number of neurons in dorsal root ganglia L4–L6 of the rat

1987 • 133 citations

The termination of primary afferents within the rat dorsal horn: Evidence for rearrangement following capsaicin treatment

1983 • 132 citations

Evidence for glycoconjugate in nociceptive primary sensory neurons and its origin from the golgi complex

1986 • 132 citations

Capsaicin: A Chemical Probe for Sensory Neuron Mechanisms

1982 • 129 citations

Loss of sensory neurons after sciatic nerve section in the rat

1987 • 129 citations

Capsaicin — A Literature Survey

1982 • 126 citations

Neurophysiological effects of capsaicin

1984 • 122 citations

Transganglionic degeneration in the spinal trigeminal nucleus following removal of tooth pulps in adult cats

1976 • 119 citations

Reciprocal regulation of tachykinin- and vasoactive intestinal peptide-gene expression in rat sensory neurones following cut and crush injury

1989 • 117 citations

Sciatic nerve transection produces death of dorsal root ganglion cells and reversible loss of substance P in spinal cord

1985 • 113 citations

Pathobiological reactions of C‐fibre primary sensory neurones to peripheral nerve injury

1992 • 111 citations

Neuronal loss in lumbar dorsal root ganglia after proximal compared to distal sciatic nerve resection: a quantitative study in the rat

1989 • 109 citations

Effect of sciatic neurectomy on neuronal number and size distribution in the L7 ganglion of kittens

1981 • 104 citations

Effects of sciatic nerve resection on L7 spinal roots and dorsal root ganglia in adult cats☆

1983 • 96 citations

Retrograde and transganglionic degeneration of sensory neurons after a peripheral nerve lesion at birth

1984 • 96 citations

Effects of capsaicin applied perineurally to the vagus nerve on cardiovascular and respiratory functions in the cat.

1983 • 92 citations

Effects of capsaicin applied to a peripheral nerve on the responses of primate spinothalamic tract cells

1985 • 91 citations

Changes in the somatotopic organization of the cat lumbar spinal cord following peripheral nerve transection and regeneration

1983 • 86 citations

Intracisternal capsaicin: Selective degeneration of chemosensitive primary sensory afferents in the adult rat

1981 • 83 citations

Transganglionic degeneration of capsaicin-sensitive C-fiber primary afferent terminals

1990 • 76 citations

Effect of cutting or crushing the rat sciatic nerve on synthesis of substance P by isolated L5 dorsal root ganglia

1987 • 76 citations

A histochemical study of the distribution of the trigeminal divisions in the substantia gelatinosa of the rat

1971 • 76 citations

Expansion of spinal cord primary sensory afferent projection following combined sciatic nerve resection and saphenous nerve crush: A horseradish peroxidase study in the adult rat

1988 • 76 citations

Immunocytochemical evidence for the localization of the GM1 ganglioside in carbonic anhydrase-containing and RT 97-immunoreactive rat primary sensory neurons

1989 • 74 citations

Functional linkage between nociception and fluoride-resistant acid phosphatase activity in the Rolando substance.

1975 • 71 citations

Ornithine decarboxylase in motoneurons during regeneration

1985 • 71 citations

Neurotransmitter phenotype plasticity in cultured dissociated adult rat dorsal root ganglia: An immunocytochemical study

1989 • 67 citations

REGENERATION OF UNMYELINATED AXONS AFTER INJURY OF MAMMALIAN PERIPHERAL NERVE

1989 • 66 citations

The receptive part of the primary afferent axon is most vulnerable to systemic capsaicin in adult rats

1990 • 66 citations

Local application of capsaicin to one sciatic nerve of the adult rat induces a marked depletion in the peptide content of the lumbar dorsal horn

1982 • 64 citations

Long‐Term Reduction in the Number of C‐Fibre Nociceptors Following Capsaicin Treatment of a Cutaneous Nerve in Adult Rats

1990 • 62 citations

Further observations on transganglionic degeneration in trigeminal primary sensory neurons

1979 • 62 citations

Effects of sciatic nerve crush on the L7 spinal roots and dorsal root ganglia in kittens

1983 • 61 citations

If Substance P Fails to Fulfil the Criteria as a Neurotransmitter in Somatosensory Afferents, what Might be its Function?

1982 • 60 citations

Reorganization of muscle afferent projections accompanies peripheral nerve regeneration

1981 • 54 citations

Somatotopic organization of the thoracic spinal nerve in the dorsal horn demonstrated with transganglionic degeneration

1981 • 53 citations

Plasticity of the peptidergic mediation of spinal reflex facilitation after peripheral nerve section in the rat

1990 • 52 citations

Altered responses of nociceptive cat lamina I spinal dorsal horn neurons after chronic sciatic neuroma formation

1987 • 52 citations

The plant lectin soybean agglutinin binds to the soma, axon and central terminals of a subpopulation of small-diameter primary sensory neurons in the rat and cat

1989 • 52 citations

Carbonic anhydrase activity in the peripheral nervous system of rat: the enzyme as a marker for muscle afferents

1989 • 51 citations

Changes in synthesis of specific proteins in axotomized dorsal root ganglia

1982 • 51 citations

An ultrastructural study of transganglionic degeneration in the main sensory trigeminal nucleus of the rat

1979 • 50 citations

PROJECTION OF DERMATOMES ON THE SUBSTANTIA GELATINOSA

1949 • 49 citations

Axonal effects of capsaicin: an electrophysiological study.

1986 • 48 citations

Effects of capsaicin on receptive fields and on inhibitions in rat spinal cord

1982 • 47 citations

Dendritic changes in the spinal dorsal horn following transection of a peripheral nerve

1984 • 46 citations

Ultrastructural localization of acid phosphatase in synaptic terminals of the rat substantia gelatinosa Rolandi

1970 • 46 citations

Peripheral axotomy of the rat mandibular trigeminal nerve leads to an increase in VIP and decrease of other primary afferent neuropeptides in the spinal trigeminal nucleus

1986 • 46 citations

Altered distribution of dorsal root fibers in the rat following neonatal capsaicin treatment

1986 • 45 citations

Transganglionic regulation and fine structural localization of lectin-reactive carbohydrate epitopes in primary sensory neurons of the rat

1988 • 45 citations

Alterations in the ipsi- and contralateral afferent inputs of dorsal horn cells produced by capsaicin treatment of one sciatic nerve in the rat

1982 • 44 citations

B-Afferents: A fundamental division of the nervous system mediating homeostasis?

1990 • 43 citations

Lectin cytochemical evaluation of somatosensory neurons and their peripheral and central processes in rat and man

1986 • 42 citations

Monoclonal antibody 2C5: A marker for a subpopulation of small neurones in rat dorsal root ganglia

1985 • 41 citations

Neonatal capsaicin treatment induces invasion of the substantia gelatinosa by the terminal arborizations of hair follicle afferents in the rat dorsal horn

1990 • 39 citations

Correlation of mitochondrial swelling after capsaicin treatment and substance P and somatostatin immunoreactivity in small neurons of dorsal root ganglion in the rat

1986 • 36 citations

Capsaicin-induced inhibition of axoplasmic transport is prevented by nerve growth factor

1985 • 36 citations

Cell death in the adult rat dorsal root ganglion after hind limb amputation, spinal cord transection, or both operations

1985 • 35 citations

Possible Use of Capsaicin in Pain Therapy

1987 • 35 citations

Degenerative and regenerative changes in central projections of glossopharyngeal and vagal sensory neurons after peripheral axotomy in cats: A structural basis for central reorganization of arterial chemoreflex pathways

1983 • 35 citations

Lectin binding: A genuine marker for transganglionic regulation of human primary sensory neurons

1985 • 35 citations

Peripheral nerve lesions cause simultaneous alterations of substance P and enkephalin levels in the spinal cord

1985 • 35 citations

Morphological alterations in dorsal root ganglion neurons after peripheral axon injury: Association with changes in metabolism

1989 • 34 citations

Structure-function relationships in identified afferent neurones

1990 • 34 citations

Axonal transport in the central axon of sensory neurons during regeneration of their peripheral axon

1981 • 34 citations

Changes in the central projection pattern of vibrissae innervating primary sensory neurons after peripheral nerve injury in the rat

1988 • 32 citations

TRANSGANGLIONIC DEGENERATION IN THE VESTIBULAR NERVE

1970 • 31 citations

Lack of central sprouting of primary afferent fibers after ricin deafferentation

1988 • 31 citations

Sequential changes of sensory neuron (fluoride-resistant) acid phosphatase in dorsal root ganglion neurons following neurectomy and rhizotomy

1985 • 30 citations

The C-fibre conduction block caused by capsaicin on rat vagus nerve in vitro

1989 • 29 citations

Nerve section alters the interaction between C-fibre activity and intrathecal neuropeptides on the flexor reflex in rat

1989 • 28 citations

Peripheral nerve regeneration induces elevated expression of GAP-43 in the brainstem trigeminal complex of adult hamsters

1989 • 27 citations

Brain stem degeneration patterns following tooth extractions: visualization of dental and periodontal afferents

1980 • 24 citations

Possible morphological correlates of capsaicin desensitization

1991 • 23 citations

Elimination of intramedullary axon collaterals of cat spinal ?-motoneurons following peripheral nerve injury

1990 • 22 citations

Changes in lectin binding of lumbar dorsal root ganglia neurons and peripheral axons after sciatic and spinal nerve injury in the rat

1989 • 21 citations

The effect of peripheral nerve section on lectin binding in the superficial dorsal horn of the rat spinal cord

1990 • 21 citations

Changes in acid phosphatase activity in the substantia gelatinosa in response to pain

1982 • 19 citations

The effects of capsaicin applied to peripheral nerves on responses of a group of lamina I cells in adult rats

1984 • 19 citations

Afferents from the facial, vago-glossopharyngeal and second cervical nerves to the substantia gelatinosa of the rat

1972 • 19 citations

Transneuronal degeneration in the Rolando substance of the primate spinal cord evoked by axotomy-induced transganglionic degenerative atrophy of central primary sensory terminals

1989 • 17 citations

Strychnine andl-allylglycine but not bicuculline and picrotoxin induce transsynaptic degeneration following transection of the inferior alveolar nerve in adult rats

1985 • 16 citations

Effect of peripheral nerve injury on receptive fields of cells in the cat spinal cord

1982 • 16 citations

Studies of vasoactive intestinal polypeptide expression in injured peripheral neurons using capsaicin, sympathectomy and mf mutant rats

1990 • 14 citations

ULTRACYTOCHEMICAL LOCALIZATION OF THIAMINE MONOPHOSPHATASE ACTIVITY IN THE SUBSTANTIA GELATINOSA OF THE RAT SPINAL CORD

1979 • 14 citations

Changes in contralateral protein metabolism following unilateral sciatic nerve section

1990 • 14 citations

Altered metabolism of rat contralateral sciatic nerve after microinjection into the endoneurium of the ipsilateral sciatic nerve

1989 • 11 citations

Classification of aberrant primary afferents in the substantia gelatinosa of the rat following neonatal capsaicin treatment

1987 • 11 citations

Neonatal capsaicin and guanethidine and axonally transported organelle- specific enzymes in sciatic nerve and in sympathetic and dorsal root ganglia

1983 • 10 citations

Ganglionic changes associated with transganglionic degeneration of capsaicin-sensitive primary sensory afferents: A quantitative morphometric and immunohistochemical study

1988 • 10 citations

Blind Axonal Endings and Plasticity in the Mammalian CNS

1990 • 5 citations

Single nerve capsaicin: Effects on pain and morphine analgesia in the formalin and foot-flick tests

1985 • 5 citations

B-afferents: A system of capsaicin-sensitive primary sensory neurons?

1990 • 4 citations

The mechanism of action of capsaicin on sensory C-type neurones and their axons in vitro

1991 • 4 citations

Ureteral axon damage following subcutaneous administration of capsaicin in adult rats

1985 • 3 citations

Degenerative changes in primary trigeminal axons and in neurons in nucleus caudalis following tooth pulp extirpations in the cat

1978 • 2 citations

Capsaicin causes selective damage to type I synaptic glomeruli in rat substantia gelatinosa

1985 • 1 citations