Molecular architecture of the kinetochore–microtubule interface

MICROTUBULE POLYMERIZATION DYNAMICS

1997 • 2,442 citations

The spindle-assembly checkpoint in space and time

2007 • 2,120 citations

On the road to cancer: aneuploidy and the mitotic checkpoint

2005 • 1,162 citations

The Conserved KMN Network Constitutes the Core Microtubule-Binding Site of the Kinetochore

2006 • 994 citations

Identification of a family of human centromere proteins using autoimmune sera from patients with scleroderma

1985 • 803 citations

Chromosomal passengers: conducting cell division

2007 • 789 citations

Kinetochore Microtubule Dynamics and Attachment Stability Are Regulated by Hec1

2006 • 739 citations

Evidence that the Ipl1-Sli15 (Aurora Kinase-INCENP) Complex Promotes Chromosome Bi-orientation by Altering Kinetochore-Spindle Pole Connections

2002 • 725 citations

The human CENP-A centromeric nucleosome-associated complex

2006 • 689 citations

A human centromere antigen (CENP-B) interacts with a short specific sequence in alphoid DNA, a human centromeric satellite.

1989 • 659 citations

Phospho-Regulation of Kinetochore-Microtubule Attachments by the Aurora Kinase Ipl1p

2002 • 612 citations

Propagation of centromeric chromatin requires exit from mitosis

2007 • 594 citations

Shugoshin collaborates with protein phosphatase 2A to protect cohesin

2006 • 569 citations

Genes Required for Mitotic Spindle Assembly in Drosophila S2 Cells

2007 • 530 citations

Does aneuploidy cause cancer?

2006 • 528 citations

Aurora B Regulates MCAK at the Mitotic Centromere

2004 • 527 citations

Conserved Organization of Centromeric Chromatin in Flies and Humans

2002 • 526 citations

Cytoplasmic dynein/dynactin drives kinetochore protein transport to the spindle poles and has a role in mitotic spindle checkpoint inactivation

2001 • 513 citations

The CENP-H–I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres

2006 • 488 citations

Asymmetric CLASP-Dependent Nucleation of Noncentrosomal Microtubules at the trans-Golgi Network

2007 • 471 citations

The case for epigenetic effects on centromere identity and function

1997 • 470 citations

Human CENP-A contains a histone H3 related histone fold domain that is required for targeting to the centromere.

1994 • 444 citations

Aurora B Phosphorylates Centromeric MCAK and Regulates Its Localization and Microtubule Depolymerization Activity

2004 • 443 citations

Functional Analysis of Kinetochore Assembly in Caenorhabditis elegans

2001 • 440 citations

Protein phosphatase 2A protects centromeric sister chromatid cohesion during meiosis I

2006 • 432 citations

Chromosomes Can Congress to the Metaphase Plate Before Biorientation

2006 • 420 citations

Mis16 and Mis18 Are Required for CENP-A Loading and Histone Deacetylation at Centromeres

2004 • 411 citations

Evidence that the MIF2 gene of Saccharomyces cerevisiae encodes a centromere protein with homology to the mammalian centromere protein CENP-C.

1995 • 410 citations

A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension

2004 • 407 citations

The inner centromere protein (INCENP) antigens: movement from inner centromere to midbody during mitosis.

1987 • 407 citations

Purification of the centromere-specific protein CENP-A and demonstration that it is a distinctive histone.

1991 • 403 citations

The dynamic kinetochore-microtubule interface

2004 • 396 citations

Structural determinants for generating centromeric chromatin

2004 • 393 citations

CENP-E, a novel human centromere-associated protein required for progression from metaphase to anaphase.

1991 • 384 citations

Requirement of Mis6 Centromere Connector for Localizing a CENP-A-Like Protein in Fission Yeast

2000 • 382 citations

Priming of Centromere for CENP-A Recruitment by Human hMis18α, hMis18β, and M18BP1

2007 • 374 citations

Incorporation of Drosophila CID/CENP-A and CENP-C into Centromeres during Early Embryonic Anaphase

2007 • 360 citations

Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities

2007 • 354 citations

The role of Drosophila CID in kinetochore formation, cell-cycle progression and heterochromatin interactions

2001 • 346 citations

CENP-C, an autoantigen in scleroderma, is a component of the human inner kinetochore plate

1992 • 340 citations

The Ndc80/HEC1 complex is a contact point for kinetochore-microtubule attachment

2006 • 339 citations

Bub1 is required for kinetochore localization of BubR1, Cenp-E, Cenp-F and Mad2, and chromosome congression

2004 • 337 citations

Mislocalization of the Drosophila Centromere-Specific Histone CID Promotes Formation of Functional Ectopic Kinetochores

2006 • 335 citations

Roles of Polo-like Kinase 1 in the Assembly of Functional Mitotic Spindles

2004 • 334 citations

CENP-E Function at Kinetochores Is Essential for Chromosome Alignment

1997 • 326 citations

PICH, a Centromere-Associated SNF2 Family ATPase, Is Regulated by Plk1 and Required for the Spindle Checkpoint

2007 • 324 citations

Analysis of the Saccharomyces Spindle Pole by Matrix-assisted Laser Desorption/Ionization (MALDI) Mass Spectrometry

1998 • 318 citations

PP2A Is Required for Centromeric Localization of Sgo1 and Proper Chromosome Segregation

2006 • 318 citations

The Ndc80p Complex from Saccharomyces cerevisiae Contains Conserved Centromere Components and Has a Function in Chromosome Segregation

2001 • 318 citations

The human mitotic checkpoint protein BubR1 regulates chromosome–spindle attachments

2004 • 306 citations

Formation of a Dynamic Kinetochore- Microtubule Interface through Assembly of the Dam1 Ring Complex

2005 • 298 citations

Vertebrate Shugoshin Links Sister Centromere Cohesion and Kinetochore Microtubule Stability in Mitosis

2004 • 296 citations

Microtubule polymerases and depolymerases

2006 • 294 citations

Polo-Like Kinases: A Team in Control of the Division

2006 • 293 citations

CENP-B box is required for de novo centromere chromatin assembly on human alphoid DNA

2002 • 291 citations

Molecular architecture of a kinetochore–microtubule attachment site

2006 • 291 citations

SUMO-1 targets RanGAP1 to kinetochores and mitotic spindles

2002 • 290 citations

Specification of kinetochore-forming chromatin by the histone H3 variant CENP-A

2001 • 289 citations

The yeast DASH complex forms closed rings on microtubules

2005 • 287 citations

Overexpression and mistargeting of centromere protein-A in human primary colorectal cancer.

2003 • 287 citations

Hierarchical assembly of the budding yeast kinetochore from multiple subcomplexes

2003 • 281 citations

hNuf2 inhibition blocks stable kinetochore–microtubule attachment and induces mitotic cell death in HeLa cells

2002 • 281 citations

Nonhistone Scm3 and Histones CenH3-H4 Assemble the Core of Centromere-Specific Nucleosomes

2007 • 280 citations

The Dam1 kinetochore ring complex moves processively on depolymerizing microtubule ends

2006 • 276 citations

Molecular organization of the Ndc80 complex, an essential kinetochore component

2005 • 266 citations

Neocentromeres: Role in Human Disease, Evolution, and Centromere Study

2002 • 265 citations

Centromere-associated protein-E is essential for the mammalian mitotic checkpoint to prevent aneuploidy due to single chromosome loss

2003 • 265 citations

CENP-E Is Essential for Reliable Bioriented Spindle Attachment, but Chromosome Alignment Can Be Achieved via Redundant Mechanisms in Mammalian Cells

2001 • 264 citations

ELYS is a dual nucleoporin/kinetochore protein required for nuclear pore assembly and proper cell division

2006 • 263 citations

A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1

2004 • 259 citations

A histone-H3-like protein in C. elegans

1999 • 254 citations

The highly conserved Ndc80 complex is required for kinetochore assembly, chromosome congression, and spindle checkpoint activity

2003 • 254 citations

Timely anaphase onset requires a novel spindle and kinetochore complex comprising Ska1 and Ska2

2006 • 252 citations

Hec1 and Nuf2 Are Core Components of the Kinetochore Outer Plate Essential for Organizing Microtubule Attachment Sites

2004 • 250 citations

ZW10 links mitotic checkpoint signaling to the structural kinetochore

2005 • 246 citations

Self-Regulated Plk1 Recruitment to Kinetochores by the Plk1-PBIP1 Interaction Is Critical for Proper Chromosome Segregation

2006 • 246 citations

MEL‐28/ELYS is required for the recruitment of nucleoporins to chromatin and postmitotic nuclear pore complex assembly

2007 • 244 citations

Proteome Analysis of the Human Mitotic Spindle

2004 • 244 citations

Centromere Identity Maintained by Nucleosomes Assembled with Histone H3 Containing the CENP-A Targeting Domain

2007 • 242 citations

The fine structure of the kinetochore of a mammalian cell in vitro

1966 • 238 citations

CENP-E as an Essential Component of the Mitotic Checkpoint In Vitro

2000 • 235 citations

Human centromere chromatin protein hMis12, essential for equal segregation, is independent of CENP-A loading pathway

2003 • 233 citations

KNL-1 directs assembly of the microtubule-binding interface of the kinetochore in C. elegans

2003 • 230 citations

Scm3 Is Essential to Recruit the Histone H3 Variant Cse4 to Centromeres and to Maintain a Functional Kinetochore

2007 • 228 citations

Spindly, a novel protein essential for silencing the spindle assembly checkpoint, recruits dynein to the kinetochore

2007 • 228 citations

Tetrameric Structure of Centromeric Nucleosomes in Interphase Drosophila Cells

2007 • 225 citations

Antibodies to the kinesin motor domain and CENP-E inhibit microtubule depolymerization-dependent motion of chromosomes in vitro.

1995 • 222 citations

Functional genomics identifies a Myb domain–containing protein family required for assembly of CENP-A chromatin

2007 • 220 citations

Architecture of the budding yeast kinetochore reveals a conserved molecular core

2003 • 217 citations

Rod–Zw10–Zwilch: a key player in the spindle checkpoint

2005 • 216 citations

Human CLASP1 Is an Outer Kinetochore Component that Regulates Spindle Microtubule Dynamics

2003 • 213 citations

Mapping the assembly pathways that specify formation of the trilaminar kinetochore plates in human cells

2006 • 212 citations

The human Mis12 complex is required for kinetochore assembly and proper chromosome segregation

2006 • 206 citations

A dual role for Bub1 in the spindle checkpoint and chromosome congression

2005 • 206 citations

Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP‐A chromatin of human cells

2006 • 205 citations

Structures and Functions of Yeast Kinetochore Complexes

2007 • 202 citations

Kinetochore Dynein Is Required for Chromosome Motion and Congression Independent of the Spindle Checkpoint

2007 • 202 citations

Structure, Function, and Regulation of Budding Yeast Kinetochores

2003 • 200 citations

The human Nup107–160 nuclear pore subcomplex contributes to proper kinetochore functions

2007 • 199 citations

Proteolysis Contributes to the Exclusive Centromere Localization of the Yeast Cse4/CENP-A Histone H3 Variant

2004 • 194 citations

The Dam1 kinetochore complex harnesses microtubule dynamics to produce force and movement

2006 • 193 citations

Drosophila CLASP is required for the incorporation of microtubule subunits into fluxing kinetochore fibres

2004 • 187 citations

Scm3, an essential Saccharomyces cerevisiae centromere protein required for G ₂ /M progression and Cse4 localization

2007 • 182 citations

Implication of ZW10 in membrane trafficking between the endoplasmic reticulum and Golgi

2004 • 179 citations

Architecture of the Human Ndc80-Hec1 Complex, a Critical Constituent of the Outer Kinetochore

2005 • 179 citations

CENP-H, a constitutive centromere component, is required for centromere targeting of CENP-C in vertebrate cells

2001 • 174 citations

CENP-A Is Required for Accurate Chromosome Segregation and Sustained Kinetochore Association of BubR1

2005 • 173 citations

Molecular mechanisms of microtubule-dependent kinetochore transport toward spindle poles

2007 • 172 citations

Proteomics analysis of the centromere complex from HeLa interphase cells: UV‐damaged DNA binding protein 1 (DDB‐1) is a component of the CEN‐complex, while BMI‐1 is transiently co‐localized with the centromeric region in interphase

2004 • 170 citations

Tension applied through the Dam1 complex promotes microtubule elongation providing a direct mechanism for length control in mitosis

2007 • 165 citations

"Holo"er than thou: Chromosome segregation and kinetochore function in C. elegans

2004 • 160 citations

Cenp-F Links Kinetochores to Ndel1/Nde1/Lis1/Dynein Microtubule Motor Complexes

2007 • 158 citations

Dynamic behavior of Nuf2-Hec1 complex that localizes to the centrosome and centromere and is essential for mitotic progression in vertebrate cells

2003 • 158 citations

The Set1 Methyltransferase Opposes Ipl1 Aurora Kinase Functions in Chromosome Segregation

2005 • 153 citations

Polo-like Kinase 1 Creates the Tension-Sensing 3F3/2 Phosphoepitope and Modulates the Association of Spindle-Checkpoint Proteins at Kinetochores

2005 • 151 citations

The Nup107-160 Nucleoporin Complex Is Required for Correct Bipolar Spindle Assembly

2006 • 149 citations

Chromosome motion during attachment to the vertebrate spindle: initial saltatory-like behavior of chromosomes and quantitative analysis of force production by nascent kinetochore fibers.

1991 • 149 citations

Human CENP-I specifies localization of CENP-F, MAD1 and MAD2 to kinetochores and is essential for mitosis

2003 • 147 citations

The Schizosaccharomyces pombe EB1 Homolog Mal3p Binds and Stabilizes the Microtubule Lattice Seam

2006 • 145 citations

Farnesylation of Cenp-F is required for G2/M progression and degradation after mitosis

2002 • 144 citations

Time-lapse Imaging Reveals Dynamic Relocalization of PP1γ throughout the Mammalian Cell Cycle

2003 • 144 citations

An epigenetic mark generated by the incorporation of CENP-A into centromeric nucleosomes

2007 • 142 citations

Tripin/hSgo2 recruits MCAK to the inner centromere to correct defective kinetochore attachments

2007 • 137 citations

HEC, a Novel Nuclear Protein Rich in Leucine Heptad Repeats Specifically Involved in Mitosis

1997 • 137 citations

CENP-I Is Essential for Centromere Function in Vertebrate Cells

2002 • 135 citations

The outer plate in vertebrate kinetochores is a flexible network with multiple microtubule interactions

2007 • 132 citations

Chaperone-mediated assembly of centromeric chromatinin vitro

2006 • 132 citations

The DASH complex and Klp5/Klp6 kinesin coordinate bipolar chromosome attachment in fission yeast

2005 • 129 citations

CENP-C Is Involved in Chromosome Segregation, Mitotic Checkpoint Function, and Kinetochore Assembly

2007 • 126 citations

A Bir1-Sli15 Complex Connects Centromeres to Microtubules and Is Required to Sense Kinetochore Tension

2006 • 124 citations

Analysis of kinesin motor function at budding yeast kinetochores

2006 • 124 citations

Centromere Protein H Is Up-regulated in Primary Human Colorectal Cancer and Its Overexpression Induces Aneuploidy

2005 • 122 citations

HZwint-1, a novel human kinetochore component that interacts with HZW10

2000 • 113 citations

Ablation of the spindle assembly checkpoint by a compound targeting Mps1

2005 • 111 citations

Glc7/Protein Phosphatase 1 Regulatory Subunits Can Oppose the Ipl1/Aurora Protein Kinase by Redistributing Glc7

2006 • 108 citations

Chemical Genetics Reveals a Role for Mps1 Kinase in Kinetochore Attachment during Mitosis

2005 • 104 citations

Hcp-4, a Cenp-C–Like Protein inCaenorhabditis elegans, Is Required for Resolution of Sister Centromeres

2001 • 104 citations

Genetic interactions of separase regulatory subunits reveal the diverged Drosophila Cenp-C homolog

2005 • 100 citations

Architecture of the Dam1 kinetochore ring complex and implications for microtubule-driven assembly and force-coupling mechanisms

2007 • 95 citations

A functional genomic screen identifies a role for TAO1 kinase in spindle-checkpoint signalling

2007 • 94 citations

MAPping the Eukaryotic Tree of Life: Structure, Function, and Evolution of the MAP215⧸Dis1 Family of Microtubule-Associated Proteins

2004 • 94 citations

Stretching it: putting the CEN(P-A) in centromere

2003 • 93 citations

Structure of a Central Component of the Yeast Kinetochore: The Spc24p/Spc25p Globular Domain

2006 • 92 citations

The CENP-F-like Proteins HCP-1 and HCP-2 Target CLASP to Kinetochores to Mediate Chromosome Segregation

2005 • 91 citations

Interactions between Centromere Complexes inSaccharomyces cerevisiae

2003 • 90 citations

CENP-F is a novel microtubule-binding protein that is essential for kinetochore attachments and affects the duration of the mitotic checkpoint delay

2006 • 90 citations

NudC Is Required for Plk1 Targeting to the Kinetochore and Chromosome Congression

2006 • 87 citations

Sumoylation of the budding yeast kinetochore protein Ndc10 is required for Ndc10 spindle localization and regulation of anaphase spindle elongation

2006 • 80 citations

CLIP-170 facilitates the formation of kinetochore–microtubule attachments

2005 • 80 citations

MEL-28 Is Downstream of the Ran Cycle and Is Required for Nuclear-Envelope Function and Chromatin Maintenance

2006 • 79 citations

The human kinetochore proteins Nnf1R and Mcm21R are required for accurate chromosome segregation

2006 • 74 citations

De Novo Kinetochore Assembly Requires the Centromeric Histone H3 Variant

2005 • 71 citations

Kinetochores Use a Novel Mechanism for Coordinating the Dynamics of Individual Microtubules

2006 • 71 citations

The Constitutive Centromere Component CENP-50 Is Required for Recovery from Spindle Damage

2005 • 70 citations

Ran-GTP regulates Kinetochore Attachment in Somatic Cells

2005 • 70 citations

Differential kinetochore protein requirements for establishment versus propagation of centromere activity in Saccharomyces cerevisiae

2003 • 59 citations

Plx1 is the 3F3/2 kinase responsible for targeting spindle checkpoint proteins to kinetochores

2005 • 59 citations

Protein Arms in the Kinetochore-Microtubule Interface of the Yeast DASH Complex

2007 • 57 citations

Xenopus Cep57 Is a Novel Kinetochore Component Involved in Microtubule Attachment

2007 • 50 citations

The Functional Region of CENP-H Interacts with the Nuf2 Complex That Localizes to Centromere during Mitosis

2005 • 45 citations

Unraveling cell division mechanisms with small-molecule inhibitors

2005 • 43 citations

Frequent expression of new cancer/testis gene D40/AF15q14 in lung cancers of smokers

2002 • 41 citations

The Conserved Spc7 Protein Is Required for Spindle Integrity and Links Kinetochore Complexes in Fission Yeast

2007 • 34 citations

Characterization of the MLL partner gene AF15q14 involved in t(11;15)(q23;q14)

2003 • 25 citations

Ran at kinetochores

2006 • 22 citations

Chromatin Proteins Are Determinants of Centromere Function

2003 • 21 citations

Using Electron Microscopy to Understand Functional Mechanisms of Chromosome Alignment on the Mitotic Spindle

2007 • 11 citations