Organelle pathology of the liver. The endoplasmic reticulum.

Pharmacological implications of microsomal enzyme induction.

1967 • 2,883 citations

Carbon tetrachloride hepatotoxicity.

1967 • 980 citations

A QUANTITATIVE STEREOLOGICAL DESCRIPTION OF THE ULTRASTRUCTURE OF NORMAL RAT LIVER PARENCHYMAL CELLS

1968 • 723 citations

Ethanol Oxidation by Hepatic Microsomes: Adaptive Increase after Ethanol Feeding

1968 • 562 citations

PHENOBARBITAL-INDUCED SYNTHESIS OF THE MICROSOMAL DRUG-METABOLIZING ENZYME SYSTEM AND ITS RELATIONSHIP TO THE PROLIFERATION OF ENDOPLASMIC MEMBRANES

1965 • 531 citations

Adaptive increases in drug-metabolizing enzymes induced by phenobarbital and other drugs.

1960 • 511 citations

THE RELATIONSHIP OF EPINEPHRINE AND GLUCAGON TO LIVER PHOSPHORYLASE

1957 • 486 citations

STUDIES ON CYTOPLASMIC RIBONUCLEOPROTEIN PARTICLES FROM THE LIVER OF THE RAT

1955 • 461 citations

Necrogenic Action of Carbon Tetrachloride in the Rat: A Speculative Mechanism Based on Activation

1966 • 457 citations

Observations on the Cytology and Electron Microscopy of Hepatic Cells<xref ref-type="fn" rid="fn1">1</xref>, <xref ref-type="fn" rid="fn2">2</xref>

1955 • 456 citations

Drug-Induced Changes in the Liver Endoplasmic Reticulum: Association with Drug-Metabolizing Enzymes

1963 • 413 citations

EFFECT OF DRUGS ON THE FORMATION OF SMOOTH ENDOPLASMIC RETICULUM AND DRUG‐METABOLIZING ENZYMES

1965 • 381 citations

Early onset of lipoperoxidation in rat liver after carbon tetrachloride administration

1968 • 360 citations

Lipoperoxidation as a vector in carbon tetrachloride hepatotoxicity.

1966 • 358 citations

An electron microscope study of the early effects of 3'-Me-DAB on rat liver cells.

1959 • 339 citations

Hepatic Microsomal Enzymes in Man and Rat: Induction and Inhibition by Ethanol

1968 • 331 citations

HYPERTROPHY OF THE AGRANULAR ENDOPLASMIC RETICULUM IN HAMSTER LIVER INDUCED BY PHENOBARBITAL (WITH A REVIEW ON THE FUNCTIONS OF THIS ORGANELLE IN LIVER)

1966 • 311 citations

The ultrastructure of fatty liver induced by prolonged ethanol ingestion.

1966 • 311 citations

LIVER PARENCHYMAL CELL INJURY

1963 • 288 citations

AN INTRACELLULAR DEFECT IN PROTEIN SYNTHESIS INDUCED BY CARBON TETRACHLORIDE

1962 • 261 citations

Enhancement of Glucuronide-Conjugating Capacity in a Hyperbilirubinemic Infant Due to Apparent Enzyme Induction by Phenobarbital

1966 • 260 citations

Factors Influencing Drug Metabolism

1962 • 258 citations

Ethanol Increases Hepatic Smooth Endoplasmic Reticulum and Drug-Metabolizing Enzymes

1968 • 247 citations

Electron microscopic and biochemical study of lipoprotein synthesis in the isolated perfused rat liver

1967 • 243 citations

Drug interactions in man

1965 • 235 citations

ON THE MECHANISM OF DRUG HYDROXYLATION IN RAT LIVER MICROSOMES

1965 • 218 citations

Increased susceptibility to carbon tetrachloride poisoning in the rat after pretreatment with oral phenobarbitone

1969 • 216 citations

Studies of Biochemical Changes in Subcellular Particles of Rat Liver and Their Relationship to a New Hypothesis Regarding the Pathogenesis of Carbon Tetrachloride Fat Accumulation

1961 • 215 citations

MORPHOLOGICAL CHANGES IN THE LIVER ACCOMPANYING STIMULATION OF MICROSOMAL DRUG METABOLIZING ENZYME ACTIVITY BY PHENOBARBITAL, CHLORDANE, BENZPYRENE OR METHYL-CHOLANTHRENE IN RATS.

1965 • 210 citations

Changes in the Fine Structure of Rat Liver Cells Brought about by Dimethylnitrosamine

1960 • 193 citations

Effects of Acute and Chronic DDT Administration on Hepatic Microsomal Drug Metabolism in the Rat.

1963 • 193 citations

Biochemical Pathology of Acute Hepatic Adenosinetriphosphate Deficiency

1964 • 192 citations

SIMILARITIES BETWEEN OXIDATIVE DRUG-METABOLIZING ENZYMES AND STEROID HYDROXYLASES IN LIVER MICROSOMES.

1964 • 186 citations

STUDIES ON ETHIONINE

1950 • 181 citations

Puromycin Inhibition of Enzyme Induction by 3-Methylcholanthrene and Phenobarbital

1963 • 179 citations

ENZYME-MEMBRANE RELATIONSHIP IN PHENOBARBITAL INDUCTION OF SYNTHESIS OF DRUG-METABOLIZING ENZYME SYSTEM AND PROLIFERATION OF ENDOPLASMIC MEMBRANES

1966 • 176 citations

Mechanism of action of carbon tetrachloride on liver cells

1954 • 175 citations

Electron microscopy of rat liver after carbon tetrachloride poisoning

1960 • 154 citations

Ethionine administration in the rat. 2. Effects on the incorporation of [32P]orthophosphate and <scp>dl</scp>-[1-14C]leucine into the phosphatides and proteins of liver and plasma

1961 • 150 citations

THE FINE STRUCTURAL LOCALIZATION OF GLUCOSE-6-PHOSPHATASE IN RAT LIVER

1962 • 148 citations

DRUG-INDUCED CHANGES IN STEROID METABOLISM

1965 • 145 citations

GLYCOGEN SYNTHESIS FROM URIDINE DIPHOSPHATE GLUCOSE

1961 • 144 citations

ELECTRON MICROSCOPY OF MEMBRANE-PARTICLE ARRAYS IN LIVER CELLS OF ETHIONINE-INTOXICATED RATS.

1964 • 142 citations

FACTORS INFLUENCING THE METABOLISM OF DRUGS IN LIVER MICROSOMES

1963 • 136 citations

ROLE OF THE SYMPATHETIC NERVOUS SYSTEM IN DRUG‐INDUCED FATTY LIVER

1963 • 136 citations

Phenobarbital-induced fine structural changes in rat liver.

1966 • 134 citations

Mode of action of antibiotics

1965 • 131 citations

Positive evidence of acceleration of lipoperoxidation in rat liver by carbon tetrachloride: experiments

1965 • 129 citations

The metabolism of drugs by subfractions of hepatic microsomes

1961 • 128 citations

EXPERIMENTAL TOXIC INJURY OF THE LIVER

1964 • 125 citations

The effect of the administration of carbon tetrachloride on the formation of plasma lipoproteins in the rat

1963 • 123 citations

Early incorporation of carbon-labeled carbon tetrachloride into rat liver particulate lipids and proteins

1969 • 122 citations

Ultrastructural cytoplasmic changes of liver cells after reversible and irreversible ischemia

1964 • 120 citations

Effect of CCl-4 in vitro and in vivo on lipid peroxidation of rat liver homogenates and subcellular fractions.

1965 • 116 citations

Studies on Carbon Tetrachloride Intoxication. III. A Subcellular Defect in Protein Synthesis^*

1965 • 115 citations

Effect of Phenobarbital on Electron Transport System, Oxidation and Reduction of Drugs in Liver Microsomes of Rats of Different Age

1968 • 111 citations

Serum lipoproteins in rats with carbon tetrachloride-induced fatty liver

1965 • 111 citations

Inhibition of the ethanol and carbon tetrachloride induced fatty liver by antioxidants

1965 • 111 citations

A LIGHT AND ELECTRON MICROSCOPE STUDY OF THE MORPHOLOGICAL CHANGES INDUCED IN RAT LIVER CELLS BY THE AZO DYE 2-ME-DAB

1964 • 108 citations

THE ROLE OF MICROSOMES IN THE INCORPORATION OF AMINO ACIDS INTO PROTEINS

1954 • 107 citations

The physiological disposition of dicumarol in man.

1950 • 105 citations

The development in the rat of fatty livers associated with reduced plasma-lipoprotein synthesis

1962 • 105 citations

A QUANTITATIVE DESCRIPTION OF CORTISONE-INDUCED ALTERATIONS IN THE ULTRASTRUCTURE OF RAT LIVER PARENCHYMAL CELLS

1968 • 104 citations

FINE STRUCTURAL CHANGES IN RAT LIVER INDUCED BY PHENOBARBITAL.

1964 • 102 citations

Effect of puromycin in vivo on the synthesis of protein, RNA and phospholipids in rat tissues

1961 • 101 citations

The inhibitory effects in vitro of phenothiazines and other drugs on lipid-peroxidation systems in rat liver microsomes, and their relationship to the liver necrosis produced by carbon tetrachloride

1968 • 97 citations

STIMULATORY EFFECT OF CHRONIC DRUG ADMINISTRATION ON DRUG‐METABOLIZING ENZYMES IN LIVER MICROSOMES

1963 • 95 citations

Toxic liver injury. Inhibition by dimethylnitrosamine of incorporation of labelled amino acids into proteins of rat-liver preparations in vitro

1960 • 93 citations

ELECTRON MICROSCOPY OF THE CYTOPLASM OF PARENCHYMAL LIVER CELLS IN ALPHA-NAPHTHYL-ISOTHIOCYANATE-INDUCED CIRRHOSIS.

1963 • 93 citations

Metabolic Derangement Induced by Alcohol

1967 • 91 citations

Sex Difference in Ethionine Inhibition of Hepatic Protein Synthesis

1958 • 91 citations

Light and electron microscopy of dichlorodiphenyltrichloroethane (DDT) poisoning in the rat liver.

1966 • 90 citations

Hypertrophic, Hypoactive Smooth Endoplasmic Reticulum: A Sensitive Indicator of Hepatotoxicity Exemplified by Dieldrin

1968 • 89 citations

The Structure of Cytoplasm

1959 • 84 citations

Studies of necrosis in vitro of mouse hepatic parenchymal cells. Ultrastructural alterations in endoplasmic reticulum, Golgi apparatus, plasma membrane, and lipid droplets.

1965 • 83 citations

Reversible Nature of Liver Cell Damage due to Carbon Tetrachloride as demonstrated by the Use of Phenergan

1961 • 78 citations

The Action of Carbon Tetrachloride on the Transport and Metabolism of Triglycerides and Fatty Acids by the Isolated Perfused Rat Liver and Its Relationship to the Etiology of Fatty Liver

1962 • 77 citations

REVERSAL BY ADENINE OF THE ETHIONINE-INDUCED LIPID ACCUMULATION IN THE ENDOPLASMIC RETICULUM OF THE RAT LIVER

1965 • 77 citations

Ethionine administration in the rat. 1. Effects on the liver and plasma lipids and on the disposal of dietary fat

1961 • 76 citations

Lipoprotein lipid transport by livers from normal and CCl₄-poisoned animals

1965 • 75 citations

Studies on the mechanism of drug-induced microsomal enzyme activities. V. Phenobarbital stimulation of endogenous messenger RNA and polyuridylic acid-directed L-[14C]-phenylalanine incorporation.

1966 • 74 citations

MALLORY ALCOHOLIC HYALIN: A HERETOFORE UNIQUE LESION OF HEPATOCELLULAR ERGASTOPLASM.

1964 • 74 citations

Metabolism of Drugs and Toxic Substances

1964 • 73 citations

The effects of carbon tetrachloride on rat liver microsomes during the first hour of poisoning in vivo, and the modifying actions of promethazine

1969 • 71 citations

Changes in rat liver cells induced by orotic acid feeding.

1966 • 70 citations

Changes associated with the production of fatty livers by white phosphorus and by ethanol in the rat

1964 • 70 citations

Effect of triparanol and diethanolamine on the fine structure of hepatocytes and pancreatic acinar cells.

1965 • 69 citations

STIMULATORY EFFECT OF PHENOBARBITAL ON THE METABOLISM OF DIPHENYLHYDANTOIN.

1963 • 68 citations

Morphologic changes in hamster liver during intrahepatic cholestasis induced by taurolithocholate.

1966 • 66 citations

On the mechanism of carbon tetrachloride hepatotoxicity: Co-incidence of loss of glucose-6-phosphatase activity with peroxidation of microsomal lipid

1965 • 66 citations

Liver parenchymal cell injury. V. Relationships between patterns of chloromethane-C 14 incorporation into constituents of liver in vivo and cellular injury.

1967 • 65 citations

Hepatocellular ultrastructure during liver regeneration after subtotal hepatectomy

1966 • 62 citations

Carbon Tetrachloride Poisoning in Rats: Alteration in Ribosomes of the Liver

1963 • 62 citations

REVERSIBLE BIOLOGICAL AND FINE STRUCTURAL CHANGES PRODUCED IN RAT LIVER BY A THIOHYDANTOIN COMPOUND.

1964 • 62 citations

RELATIONSHIP BETWEEN GLYCOGEN AND AGRANULAR ENDOPLASMIC RETICULUM IN RAT HEPATIC CELLS

1966 • 59 citations

Concentric lamellar formations in hepatic parenchymal cells of carbon tetrachloride-treated rats

1966 • 59 citations

Protection by Antioxidants against Lethal Doses of Carbon Tetrachloride

1961 • 58 citations

Penetration of Lipid Films by Compounds Preventing Liver Necrosis in Rats

1962 • 55 citations

Lipid transport in liver. II. Electron microscopic and biochemical studies of alterations in lipoprotein transport induced by cortisone in the rabbit.

1968 • 55 citations

Drug Metabolism and Therapeutics

1969 • 54 citations

On the significance of the hypertrophy of the smooth endoplasmic reticulum in liver cells after administration of drugs

1967 • 54 citations

EFFECT OF AZASERINE ON THE FINE STRUCTURE OF THE LIVER AND PANCREATIC ACINAR CELLS.

1965 • 53 citations

HEPATIC PARENCHYMAL CELL ALTERATIONS AFTER LONG-TERM CARBON TETRACHLORIDE ADMINISTRATION. A LIGHT AND ELECTRON MICROSCOPIC STUDY.

1963 • 51 citations

EFFECT OF BETA-3-FURYLALANINE ON THE ULTRASTRUCTURE OF THE HEPATOCYTES AND PANCREATIC ACINAR CELLS.

1965 • 51 citations

Choline deficiency fatty liver. Protein synthesis and release.

1967 • 51 citations

THE FINE STRUCTURE OF PROLIFERATING CELLS IN PRENEOPLASTIC RAT LIVERS DURING AZO-DYE CARCINOGENESIS

1969 • 49 citations

Ultrastructural renal alterations following tannic acid administration to rabbits.

1966 • 48 citations

Changes in liver nucleotide concentrations in experimental liver injury. 1. Carbon tetrachloride poisoning

1964 • 46 citations

Alterations in the fine structure of hepatocytes produced by β-3-thienylalanine

1963 • 45 citations

Glucose-6-Phosphatase in Tubular Endoplasmic Reticulum of Hepatocytes

1966 • 43 citations

[Toxic liver injury].

1970 • 42 citations

Studies on carbon tetrachloride intoxication. IV. Effect of carbon tetrachloride on liver slices and isolated organelles in vitro.

1966 • 42 citations

Electron microscopy of hepatic regeneration

1964 • 42 citations

THE FINE STRUCTURE OF HEPATIC CELLS IN CHRONIC ETHIONINE POISONING AND DURING RECOVERY.

1965 • 40 citations

Hydrazine-induced alterations in rat liver. A correlation of the chemical and histologic changes in acute hydrazine intoxication.

1962 • 40 citations

Effects of starvation on the hepatotoxicity of carbon tetrachloride. A light and electron microscopic study.

1966 • 39 citations

Morphogenesis of toxic fat-induced concentric membrane arrays in rat hepatocytes.

1969 • 37 citations

THE EFFECTS OF HYDRAZINE UPON THE METABOLISM OF AMINO ACIDS IN THE RAT LIVER.

1963 • 35 citations

Subcellular alterations in rat liver following hypophysectomy

1967 • 34 citations

Interaction of drugs and hepatic microsomes.

1962 • 34 citations

Increased Bishydroxycoumarin Requirements in Patients Receiving Phenobarbital

1965 • 34 citations

Spectrum of fine structural changes in hepatocellular injury due to thioacetamide.

1965 • 32 citations

ELECTRON MICROSCOPE STUDIES ON ENZYME ACTIVITY AND THE ISOLATION OF THIOHYDANTOIN-INDUCED MYELIN FIGURES IN RAT LIVER

1965 • 32 citations

EFFECTS OF THIOACETAMIDE AND YELLOW PHOSPHORUS POISONING ON PROTEIN SYNTHESIS IN VIVO.

1963 • 32 citations

The metabolism of drugs by hepatic microsomal enzymes. Studies on intramicrosomal distribution of enzymes and relationships between enzyme activity and structure of the hepatic endoplasmic reticulum

1966 • 30 citations

The early effects of actinomycin on rat liver. Changes in ribosomes and polysomes.

1965 • 30 citations

HYPERTROPHY OF LIVER CELL SMOOTH SURFACED RETICULUM FOLLOWING PROGESTERONE ADMINISTRATION

1968 • 30 citations

PATHOGENESIS OF OROTIC ACID-INDUCED FATTY CHANGE IN THE RAT LIVER: LIGHT AND ELECTRON MICROSCOPIC STUDIES.

1965 • 29 citations

Effects of SKF 525-A and adrenalectomy on the amino acid incorporation by rat liver microsomes from normal and CCl4-treated rats

1966 • 29 citations

Morphological Changes in the Livers of Rats Resulting from Exposure to Certain Chlorinated Hydrocarbons.

1938 • 28 citations

Hepatocellular ultrastructure in dogs with hypovolemic shock.

1968 • 27 citations

FAT ACCUMULATION IN ACUTE LIVER INJURY

1963 • 26 citations

CHANGES IN FUNCTION AND STRUCTURE OF THE ENDOPLASMIC RETICULUM OF RAT LIVER CELLS AFTER ADMINISTRATION OF CYSTEINE

1962 • 25 citations

Effects of chronic DDT intoxication in rats on lipids and other constituents of liver.

1947 • 24 citations

Lipid metabolism in liver injury caused by carbon tetrachloride in the rat

1964 • 23 citations

Long-term alcohol administration. Its effects on the ultrastructure and lipid content of the rat liver cell.

1966 • 21 citations

Biotransformation in the Liver: Implications for Human Disease

1968 • 21 citations

Alterations of lipoprotein metabolism in orotic acid-induced fatty liver.

1966 • 20 citations

ACTION OF DRUGS ON HEPATIC ORGANELLES*

1963 • 18 citations

Hepatotoxic and Carcinogenic Effects of Dimethylnitrosamine in Low Dosage. Light and Electron Microscopic Study&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;

1968 • 17 citations

Biochemical changes in the endoplasmic reticulum in liver injury

1966 • 16 citations

THE EFFECT OF CARBON TETRACHLORIDE ON HEPATIC LIPID METABOLISM

1964 • 15 citations

An autoradiographic study of protein synthesis in mouse liver parenchymal cells during CC14 intoxication.

1969 • 15 citations

Metabolism of saturated 1-14C-labelled fatty acids in the silkworm Bombyx mori L.

1966 • 14 citations

MEPERIDINE N-DEMETHYLASE ACTIVITY IN RAT LIVER

1964 • 14 citations

STUDIES ON CARBON TETRACHLORIDE INTOXICATION. II. DEPRESSED AMINO ACID INCORPORATION INTO MITOCHONDRIAL PROTEIN AND CYTOCHROME C.

1964 • 9 citations

CHANGES IN LIPID METABOLISM DURING THE DEVELOPMENT OF THE FATTY LIVER.

1964 • 8 citations

HYALINE BODIES IN CARBON TETRACHLORIDE-DAMAGED HEPATIC CELLS: NUCLEOSIDEDIPHOSPHATASE ACTIVITY

1966 • 7 citations

ALTERATIONS IN THE FINE STRUCTURE OF LIVER CELLS DURING DEPRESSED CATALASE SYNTHESIS IN THE MOUSE.

1964 • 7 citations