Oxidation of xenobiotics by recombinant human cytochrome P450 1B1.

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

The Carbon Monoxide-binding Pigment of Liver Microsomes

1964 • 11,832 citations

P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature

1996 • 2,895 citations

Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.

1994 • 2,716 citations

Some properties of a detergent-solubilized NADPH-cytochrome c(cytochrome P-450) reductase purified by biospecific affinity chromatography.

1976 • 1,180 citations

Oxidation of toxic and carcinogenic chemicals by human cytochrome P-450 enzymes

1991 • 997 citations

Activation of chemically diverse procarcinogens by human cytochrome P-450 1B1.

1996 • 793 citations

Human Cytochrome P450 Enzymes

1995 • 731 citations

Human cytochrome P-450PA (P-450IA2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines.

1989 • 643 citations

17 beta-estradiol hydroxylation catalyzed by human cytochrome P450 1B1.

1996 • 621 citations

Hydroxylation of chlorzoxazone as a specific probe for human liver cytochrome P-450IIE1

1990 • 535 citations

Metabolism of polycyclic aromatic hydrocarbons: etiologic role in carcinogenesis.

1982 • 520 citations

Complete cDNA sequence of a human dioxin-inducible mRNA identifies a new gene subfamily of cytochrome P450 that maps to chromosome 2.

1994 • 503 citations

Role of Human Cytochromes P450 in the Metabolic Activation of Chemical Carcinogens and Toxins

1994 • 498 citations

Expression of Modified Human Cytochrome P450 3A4 in Escherichia coli and Purification and Reconstitution of the Enzyme

1993 • 341 citations

Targets for Dioxin: Genes for Plasminogen Activator Inhibitor-2 and Interleukin-1β

1991 • 336 citations

Purification and characterization of human liver microsomal cytochrome P-450 2A6.

1991 • 267 citations

Human liver microsomal cytochrome P-450 enzymes involved in the bioactivation of procarcinogens detected by umu gene response in Salmonella typhimurium TA 1535/pSK1002.

1989 • 265 citations

High-performance liquid chromatographic assays for bufuralol 1′-hydroxylase, debrisoquine 4-hydroxylase, and dextromethorphan O-demethylase in microsomes and purified cytochrome P-450 isozymes of human liver

1987 • 262 citations

Human liver microsomal cytochrome P-450 mephenytoin 4-hydroxylase, a prototype of genetic polymorphism in oxidative drug metabolism. Purification and characterization of two similar forms involved in the reaction.

1986 • 258 citations

Characterization of human lung microsomal cytochrome P-450 1A1 and its role in the oxidation of chemical carcinogens.

1992 • 230 citations

The Cytochrome P450 I Gene Family of Microsomal Hemoproteins and Their Role in the Metabolic Activation of Chemicals

1990 • 222 citations

Mouse cytochrome P-450EF, representative of a new 1B subfamily of cytochrome P-450s. Cloning, sequence determination, and tissue expression.

1994 • 209 citations

Expression of Modified Human Cytochrome P450 1A2 in Escherichia coli: Stabilization, Purification, Spectral Characterization, and Catalytic Activities of the Enzyme

1994 • 186 citations

Identification of a Rat Adrenal Cytochrome P450 Active in Polycyclic Hydrocarbon Metabolism as Rat CYP1B1

1995 • 169 citations

Interaction between NADPH-cytochrome p-450 reductase and cytochrome p-450 in the membrane of phosphatidylcholine vesicles

1979 • 159 citations

Lidocaine metabolism by human cytochrome P-450s purified from hepatic microsomes: comparison of those with rat hepatic cytochrome P-450s.

1990 • 141 citations

Expression of Modified Human Cytochrome P450 2E1 in Escherichia coli, Purification, and Spectral and Catalytic Properties

1994 • 140 citations

Roles of Cytochrome b5in the Oxidation of Testosterone and Nifedipine by Recombinant Cytochrome P450 3A4 and by Human Liver Microsomes

1996 • 140 citations

Hepatic metabolism of tolbutamide: characterization of the form of cytochrome P-450 involved in methyl hydroxylation and relationship to in vivo disposition.

1987 • 130 citations

Both cytochromes P450 2E1 and 1A1 are involved in the metabolism of chlorzoxazone

1993 • 117 citations

Expression of Modified Human Cytochrome P450 1A1 in Escherichia coli: Effects of 5′ Substitution, Stabilization, Purification, Spectral Characterization, and Catalytic Properties

1994 • 108 citations

Expression of Cytochrome P450 2D6 in Escherichia coli, Purification, and Spectral and Catalytic Characterization

1995 • 104 citations

Different Response of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)-Sensitive Genes in Human Breast Cancer MCF-7 and MDA-MB 231 Cells

1995 • 103 citations

[16] Production and application of antibodies to rat liver cytochrome P-450

1981 • 101 citations

Bufuralol hydroxylation by cytochrome P450 2D6 and 1A2 enzymes in human liver microsomes.

1994 • 100 citations

Polycyclic aromatic hydrocarbon metabolism in rat adrenal, ovary, and testis microsomes is catalyzed by the same novel cytochrome P450 (P450RAP).

1992 • 100 citations

Rat CYP1B1: an adrenal cytochrome P450 that exhibits sex-dependent expression in livers and kidneys of TCDD-treated animals

1995 • 98 citations

A Novel Adrenocorticotropin-Inducible Cytochrome P450 from Rat Adrenal Microsomes Catalyzes Polycylic Aromatic Hydrocarbon Metabolism*

1991 • 95 citations

Theophylline metabolism in human liver microsomes: inhibition studies.

1996 • 92 citations

Mammary carcinogenicity in female CD rats of fjord region diol epoxides of benzo[c]phenanthrene, benzo[g]chrysene and dibenzo[a,l]pyrene

1995 • 82 citations

Cytochrome P-450-mediated activation of pro-carcinogens and promutagens to DNA-damaging products by measuring expression of umu gene in Salmonella typhimurium TA1535/pSK1002

1987 • 71 citations

Selectivity of cytochrome P4502E1 in chlorzoxazone 6-hydroxylation.

1995 • 71 citations

cDNA Cloning, Sequence Analysis, and Induction by Aryl Hydrocarbons of a Murine Cytochrome P450 Gene,Cyp1b1

1994 • 65 citations

Requirements for cytochrome b5 in the oxidation of 7-ethoxycoumarin, chlorzoxazone, aniline, and N-nitrosodimethylamine by recombinant cytochrome P450 2E1 and by human liver microsomes

1996 • 65 citations

Purification and immunological characterization of a novel cytochrome P450 from C3H/10T1/2 cells

1991 • 64 citations

Metabolic activation of environmental carcinogens and mutagens by human liver microsomes

1988 • 52 citations

Catalytic roles of rat and human cytochrome P450 2A enzymes in testosterone 7α- and coumarin 7-hydroxylations

1994 • 52 citations

High Rates of Substrate Hydroxylation by Human Cytochrome P450 3A4 in Reconstituted Membranous Vesicles: Influence of Membrane Charge

1996 • 51 citations

Potent mammary carcinogenicity in female CD rats of a fjord region diol-epoxide of benzo[c]phenanthrene compared to a bay region diol-epoxide of benzo[a]pyrene.

1994 • 47 citations

Mechanism of action of food-associated polycyclic aromatic hydrocarbon carcinogens

1991 • 47 citations

Dual regulation of cytochrome P450EF expression via the aryl hydrocarbon receptor and protein stabilization in C3H/10T1/2 cells.

1994 • 42 citations

Dose-response relationship of cytochrome P4501b1 mRNA induction by 2,3,7,8-tetrachlorodibenzo- p -dioxin in livers of C57BL/6J and DBA/2J mice

1996 • 38 citations

Reactivity with DNA bases and mutagenicity toward Salmonella typhimurium of methylchrysene diol epoxide enantiomers.

1988 • 17 citations