A novel in situ hybridization signal amplification method based on the deposition of biotinylated tyramine.

Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures.

1981 • 14,396 citations

The use of avidin-biotin interaction in immunoenzymatic techniques.

1979 • 1,734 citations

High-Resolution Mapping of Human Chromosome 11 by in Situ Hybridization with Cosmid Clones

1990 • 1,357 citations

Biotin amplification of biotin and horseradish peroxidase signals in histochemical stains.

1992 • 651 citations

Catalyzed reporter deposition, a novel method of signal amplification

1991 • 403 citations

Oligonucleotide-priming methods for the chromosome-specific labelling of alpha satellite DNA in situ

1989 • 294 citations

Detection of numerical chromosome aberrations using in situ hybridization in paraffin sections of routinely processed bladder cancers.

1991 • 207 citations

Rapid interphase and metaphase assessment of specific chromosomal changes in neuroectodermal tumor cells by in situ hybridization with chemically modified DNA probes

1988 • 177 citations

Mapping of single-copy DNA sequences on human chromosomes by in situ hybridization with biotinylated probes: enhancement of detection sensitivity by intensified-fluorescence digital-imaging microscopy.

1989 • 138 citations

Novel non-isotopic in situ hybridization technique detects small (1 Kb) unique sequences in routinely G-banded human chromosomes: fine mapping of N-myc and β-NGF genes

1987 • 112 citations

Evolutionary approach to the question of immunoglobulin heavy chain switching: evidence from cloned human and mouse genes.

1980 • 97 citations

Interphase cytogenetics of tumours

1992 • 82 citations

Rapid chromosome identification by oligonucleotide-primed in situ DNA synthesis (PRINS)

1994 • 77 citations

Localization and polymorphism of a chromosome 12-specific α satellite DNA sequence

1990 • 73 citations

Chromosome specificity of satellite DNAs: short- and long-range organization of a diverged dimeric subset of human alpha satellite from chromosome 3

1989 • 62 citations

PCR in situ: a rapid alternative to in situ hybridization for mapping short, low copy number sequences without isotopes.

1993 • 58 citations

Detection of genomic changes in cancer byin situ hybridization

1994 • 51 citations

Mapping and chromosome analysis: the potential of fluorescence in situ hybridization

1994 • 46 citations

Quantification of fluorescence in situ hybridization signals by image cytometry

1992 • 43 citations

DNA in situ hybridization as a diagnostic tool in the discrimination of melanoma and spitz naevus

1994 • 36 citations

Application and comparison of silver intensification methods for the diaminobenzidine and diaminobenzidine-nickel endproduct of the peroxidation reaction in immunohistochemistry and in situ hybridization.

1992 • 34 citations

Identification of numerical chromosome aberrations in archival tumours by in situ hybridization to routine paraffin sections: Evaluation of 23 phaeochromocytomas

1993 • 25 citations

Double-target in situ hybridization in brightfield microscopy.

1994 • 20 citations