Substrate/propeptide‐derived endo‐epoxysuccinyl peptides as highly potent and selective cathepsin B inhibitors

The slow-binding and slow, tight-binding inhibition of enzyme-catalysed reactions

1982 • 488 citations

Cellular Biology and Biochemical Mechanism of Bone Resorption

1988 • 383 citations

Novel epoxysuccinyl peptides Selective inhibitors of cathepsin B, in vitro

1991 • 271 citations

Cysteine proteinases and metastasis

1984 • 211 citations

Crystal structure of cathepsin B inhibited with CA030 at 2.0-.ANG. resolution: A basis for the design of specific epoxysuccinyl inhibitors

1995 • 177 citations

Potent slow-binding inhibition of cathepsin B by its propeptide

1992 • 173 citations

Structure of rat procathepsin B: model for inhibition of cysteine protease activity by the proregion

1996 • 170 citations

Crystal structure of a papain-E-64 complex

1989 • 150 citations

Identification of proteases that process distinct epitopes on the same protein.

1989 • 147 citations

Crystal structures of human procathepsin B at 3.2 and 3.3 Å resolution reveal an interaction motif between a papain‐like cysteine protease and its propeptide

1996 • 139 citations

Cysteine Proteinase Inhibitors Decrease Articular Cartilage and Bone Destruction in Chronic Inflammatory Arthritis

1994 • 124 citations

Recombinant pro-regions from papain and papaya proteinase IV are selective high affinity inhibitors of the mature papaya enzymes

1995 • 111 citations

Vacuolar/lysosomal proteolysis: proteases, substrates mechanisms

1993 • 97 citations

Crystal structure of an actinidin-E-64 complex

1992 • 86 citations

Refined x-ray structure of papain.E-64-c complex at 2.1-A resolution

1991 • 70 citations

Crystal structure of papain-E64-c complex. Binding diversity of E64-c to papain S2 and S3 subsites

1992 • 68 citations

Abnormal expression of lysosomal cysteine proteinases in muscle wasting diseases

1987 • 64 citations

Binding Mode of CA074, a Specific Irreversible Inhibitor, to Bovine Cathepsin B as Determined by X-Ray Crystal Analysis of the Complex

1997 • 55 citations

Chapter 2 Cysteine proteinases

1987 • 46 citations

Epoxysuccinyl dipeptides as selective inhibitors of cathepsin B

1993 • 45 citations

E-64 analogues as inhibitors of cathepsin B. On the role of the absolute configuration of the epoxysuccinyl group

1997 • 42 citations

Temporary inhibition of papain by hairpin loop mutants of chicken cystatin Distorted binding of the loops results in cleavage of the Gly⁹‐Ala¹⁰ bond

1995 • 36 citations

A convenient synthesis of optically pure (2R, 3R)-2, 3- Epoxysuccinyl - dipeptides

1994 • 17 citations