Protein Turnover Via Autophagy: Implications for Metabolism

LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing

2000 • 6,302 citations

Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice

2006 • 3,685 citations

Development by Self-Digestion

2004 • 3,562 citations

Loss of autophagy in the central nervous system causes neurodegeneration in mice

2006 • 3,331 citations

p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death

2005 • 3,045 citations

The role of autophagy during the early neonatal starvation period

2004 • 2,753 citations

Autophagy in Health and Disease: A Double-Edged Sword

2004 • 2,470 citations

In Vivo Analysis of Autophagy in Response to Nutrient Starvation Using Transgenic Mice Expressing a Fluorescent Autophagosome Marker

2003 • 2,218 citations

Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice

2005 • 2,207 citations

Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene

2003 • 2,136 citations

Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor

2003 • 2,041 citations

Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death

2004 • 1,959 citations

A ubiquitin-like system mediates protein lipidation

2000 • 1,929 citations

Isolation and characterization of autophagy‐defective mutants of Saccharomyces cerevisiae

1993 • 1,649 citations

A protein conjugation system essential for autophagy

1998 • 1,594 citations

Autophagy: molecular machinery for self-eating

2005 • 1,468 citations

Growth Factor Regulation of Autophagy and Cell Survival in the Absence of Apoptosis

2005 • 1,448 citations

Dissection of Autophagosome Formation Using Apg5-Deficient Mouse Embryonic Stem Cells

2001 • 1,310 citations

LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation

2004 • 1,305 citations

Starvation in Man

1970 • 1,242 citations

Autophagy Genes Are Essential for Dauer Development and Life-Span Extension in C. elegans

2003 • 1,214 citations

Molecular dissection of autophagy: two ubiquitin-like systems

2001 • 1,208 citations

Autophagy in yeast demonstrated with proteinase-deficient mutants and conditions for its induction.

1992 • 1,187 citations

Autophagy Defends Cells Against Invading Group A Streptococcus

2004 • 1,042 citations

Lysosomal Turnover, but Not a Cellular Level, of Endogenous LC3 is a Marker for Autophagy

2005 • 1,038 citations

The pre-autophagosomal structure organized by concerted functions of APG genes is essential for autophagosome formation

2001 • 979 citations

The Reversible Modification Regulates the Membrane-Binding State of Apg8/Aut7 Essential for Autophagy and the Cytoplasm to Vacuole Targeting Pathway

2000 • 932 citations

Role and Regulation of Starvation-Induced Autophagy in the Drosophila Fat Body

2004 • 927 citations

Macroautophagy—a novel β-amyloid peptide-generating pathway activated in Alzheimer's disease

2005 • 916 citations

The molecular machinery of autophagy: unanswered questions

2004 • 900 citations

Methods for monitoring autophagy

2004 • 882 citations

Formation Process of Autophagosome Is Traced with Apg8/Aut7p in Yeast

1999 • 850 citations

Escape of Intracellular Shigella from Autophagy

2004 • 798 citations

Studies on the mechanisms of autophagy: formation of the autophagic vacuole.

1990 • 789 citations

Autophagy and Aging: The Importance of Maintaining "Clean" Cells

2005 • 773 citations

Mouse Apg16L, a novel WD-repeat protein, targets to the autophagic isolation membrane with the Apg12-Apg5 conjugate

2003 • 733 citations

GABAA-receptor-associated protein links GABAA receptors and the cytoskeleton

1999 • 722 citations

Methods for Monitoring Autophagy from Yeast to Human

2007 • 637 citations

Regulation and role of autophagy in mammalian cells

2004 • 602 citations

Recurrent Mutation of the Gene Encoding sequestosome 1 (SQSTM1/p62) in Paget Disease of Bone

2002 • 538 citations

LC3, an Autophagosome Marker, Can be Incorporated into Protein Aggregates Independent of Autophagy: Caution in the Interpretation of LC3 Localization

2007 • 533 citations

The Molecular Mechanism of Autophagy

2003 • 519 citations

Consequences of the selective blockage of chaperone-mediated autophagy

2006 • 490 citations

A New Protein Conjugation System in Human

1998 • 476 citations

The pleiotropic role of autophagy: from protein metabolism to bactericide

2005 • 465 citations

Vacuolar Import of Proteins and Organelles From The Cytoplasm

1999 • 459 citations

Does Autophagy Contribute To Cell Death?

2005 • 439 citations

Intracellular Protein Catabolism and its Control During Nutrient Deprivation and Supply

1987 • 437 citations

Cellular autophagy: surrender, avoidance and subversion by microorganisms

2004 • 435 citations

Autophagy and Its Possible Roles in Nervous System Diseases, Damage and Repair

2005 • 424 citations

The atypical PKC-interacting protein p62 channels NF-kappa B activation by the IL-1-TRAF6 pathway

2000 • 422 citations

Apg16p is required for the function of the Apg12p–Apg5p conjugate in the yeast autophagy pathway

1999 • 418 citations

Autophagy Is Required for Maintenance of Amino Acid Levels and Protein Synthesis under Nitrogen Starvation

2005 • 417 citations

Formation of the ∼350-kDa Apg12-Apg5·Apg16 Multimeric Complex, Mediated by Apg16 Oligomerization, Is Essential for Autophagy in Yeast

2002 • 411 citations

Microtubules Facilitate Autophagosome Formation and Fusion of Autophagosomes with Endosomes

2005 • 408 citations

Uth1p Is Involved in the Autophagic Degradation of Mitochondria

2004 • 406 citations

Apg7p/Cvt2p: A Novel Protein-activating Enzyme Essential for Autophagy

1999 • 391 citations

Autophagy, Cytoplasm-to-Vacuole Targeting Pathway, and Pexophagy in Yeast and Mammalian Cells

2000 • 359 citations

Cerebral Ischemia-Hypoxia Induces Intravascular Coagulation and Autophagy

2006 • 358 citations

Autophagosome Requires Specific Early Sec Proteins for Its Formation and NSF/SNARE for Vacuolar Fusion

2001 • 348 citations

Protein Synthesis upon Acute Nutrient Restriction Relies on Proteasome Function

2005 • 336 citations

Participation of Autophagy in Storage of Lysosomes in Neurons from Mouse Models of Neuronal Ceroid-Lipofuscinoses (Batten Disease)

2005 • 329 citations

Tracker Dyes to Probe Mitochondrial Autophagy (Mitophagy) in Rat Hepatocytes

2006 • 322 citations

The Human Homolog of Saccharomyces cerevisiae Apg7p Is a Protein-activating Enzyme for Multiple Substrates Including Human Apg12p, GATE-16, GABARAP, and MAP-LC3

2001 • 320 citations

Induction of Autophagy in Axonal Dystrophy and Degeneration

2006 • 309 citations

Two ubiquitin-like conjugation systems essential for autophagy

2004 • 304 citations

Apg10p, a novel protein-conjugating enzyme essential for autophagy in yeast

1999 • 296 citations

Chaperone‐Mediated Autophagy in Aging and Disease

2006 • 294 citations

Mature-onset obesity and insulin resistance in mice deficient in the signaling adapter p62

2006 • 277 citations

Inhibition by insulin of the formation of autophagic vacuoles in rat liver. A morphometric approach to the kinetics of intracellular degradation by autophagy.

1978 • 276 citations

Lens Organelle Degradation

2002 • 275 citations

Pexophagy: The Selective Autophagy of Peroxisomes

2005 • 268 citations

Atg9 Cycles Between Mitochondria and the Pre-Autophagosomal Structure in Yeasts

2005 • 258 citations

Atg22 Recycles Amino Acids to Link the Degradative and Recycling Functions of Autophagy

2006 • 254 citations

Book ReviewObesity.

1970 • 244 citations

GATE-16, a membrane transport modulator, interacts with NSF and the Golgi v-SNARE GOS-28

2000 • 240 citations

A Single Protease, Apg4B, Is Specific for the Autophagy-related Ubiquitin-like Proteins GATE-16, MAP1-LC3, GABARAP, and Apg8L

2003 • 239 citations

The Itinerary of a Vesicle Component, Aut7p/Cvt5p, Terminates in the Yeast Vacuole via the Autophagy/Cvt Pathways

2000 • 233 citations

Excess Peroxisomes Are Degraded by Autophagic Machinery in Mammals

2005 • 226 citations

Quantitative relationship between autophagy and proteolysis during graded amino acid deprivation in perfused rat liver.

1981 • 223 citations

Macroautophagy Is Required for Multicellular Development of the Social Amoeba Dictyostelium discoideum

2003 • 216 citations

Apg7p/Cvt2p Is Required for the Cytoplasm-to-Vacuole Targeting, Macroautophagy, and Peroxisome Degradation Pathways

1999 • 216 citations

Interaction of protein kinase C ζ with ZIP, a novel protein kinase C-binding protein

1997 • 214 citations

Human Autophagins, a Family of Cysteine Proteinases Potentially Implicated in Cell Degradation by Autophagy

2003 • 209 citations

Peroxisome degradation in Saccharomyces cerevisiae is dependent on machinery of macroautophagy and the Cvt pathway

1999 • 202 citations

In Vivo and in Vitro Reconstitution of Atg8 Conjugation Essential for Autophagy

2004 • 201 citations

Branched-chain amino acids as a protein- and energy-source in liver cirrhosis

2003 • 189 citations

Molecular cloning of a phosphotyrosine-independent ligand of the p56lck SH2 domain.

1996 • 183 citations

Autophagy in Yeast: ATOR-Mediated Response to Nutrient Starvation

2004 • 178 citations

Changes in the proteolytic activities of proteasomes and lysosomes in human fibroblasts produced by serum withdrawal, amino-acid deprivation and confluent conditions

2003 • 167 citations

Starvation Triggers the Delivery of the Endoplasmic Reticulum to the Vacuole via Autophagy in Yeast

2004 • 166 citations

Amino Acids as Regulators of Proteolysis

2003 • 163 citations

The crystal structure of microtubule‐associated protein light chain 3, a mammalian homologue of Saccharomyces cerevisiae Atg8

2004 • 153 citations

Nuclear cataract caused by a lack of DNA degradation in the mouse eye lens

2004 • 142 citations

Molecular Mechanisms and Regulation of Specific and Nonspecific Autophagy Pathways in Yeast

2005 • 141 citations

Glucose-induced Autophagy of Peroxisomes inPichia pastorisRequires a Unique E1-like Protein

1999 • 128 citations

Early Stages of the Secretory Pathway, but Not Endosomes, Are Required for Cvt Vesicle and Autophagosome Assembly inSaccharomyces cerevisiae

2004 • 127 citations

The Crystal Structure of Plant ATG12 and its Biological Implication in Autophagy

2005 • 120 citations

Autophagy and p70S6 Kinase

2005 • 119 citations

Ald6p Is a Preferred Target for Autophagy in Yeast, Saccharomyces cerevisiae

2004 • 110 citations

Peroxisome Biogenesis and Selective Degradation Converge at Pex14p

2001 • 109 citations

The Roles of Autophagy in Cerebral Ischemia

2007 • 105 citations

Degradation of short and long lived proteins in isolated rat liver lysosomes. Effects of pH, temperature, and proteolytic inhibitors.

1985 • 105 citations

Organelle degradation during the lens and erythroid differentiation is independent of autophagy

2005 • 105 citations

The Physiology of Starvation

1971 • 104 citations

The Drosophila homolog of Aut1 is essential for autophagy and development

2003 • 102 citations

The Early Secretory Pathway Contributes to Autophagy in Yeast.

2003 • 100 citations

Ubiquitin-protein conjugates accumulate in the lysosomal system of fibroblasts treated with cysteine proteinase inhibitors

1989 • 91 citations

Autophagy and antigen presentation

2006 • 89 citations

Characterization of a novel autophagy-specific gene, ATG29

2005 • 89 citations

Murine Peritoneal Macrophages Induce a Novel 60-kDa Protein with Structural Similarity to a Tyrosine Kinase p56lck-Associated Protein in Response to Oxidative Stress

1996 • 86 citations

Ubiquitinated protein conjugates are specifically enriched in the lysosomal system of fibroblasts

1990 • 85 citations

The Mouse APG10 Homologue, an E2-like Enzyme for Apg12p Conjugation, Facilitates MAP-LC3 Modification

2003 • 78 citations

Immunoelectron microscopic localization of ubiquitin in hepatoma cells.

1988 • 74 citations

Vanadate inhibits protein degradation in isolated rat hepatocytes.

1981 • 70 citations

Suppression of cytoplasmic protein uptake by lysosomes as the mechanism of protein regain in livers of starved-refed mice.

1982 • 69 citations

Metabolic Effects of Short Term Food Deprivation in the Rat

1981 • 68 citations

Structure-Function Relationship of Atg12, a Ubiquitin-Like Modifier Essential for Autophagy

2005 • 67 citations

Atg28, a Novel Coiled-Coil Protein Involved in Autophagic Degradation of Peroxisomes in the Methylotrophic Yeast Pichia pastoris

2006 • 49 citations

Mouse Apg10 as an Apg12‐conjugating enzyme: analysis by the conjugation‐mediated yeast two‐hybrid method

2002 • 48 citations

Effect of starvation on the charging levels of transfer ribonucleic acid and total acceptor capacity in rat liver

1977 • 24 citations

Ubiquitinated aldolase B accumulates during starvation-induced lysosomal proteolysis

1999 • 19 citations

Crystallization and preliminary X-ray analysis of LC3-I

2003 • 18 citations

Protein synthesis rates in rat muscle and skin based on lysyl-tRNA radioactivity

1983 • 18 citations

Mechanism and regulation of lysosomal sequestration and proteolysis.

1991 • 15 citations

Nutritional and Hormonal Regulation of the Activity State of Hepatic Branched‐Chain α‐Keto Acid Dehydrogenase Complex^a

1989 • 14 citations

Degradation of endogenous proteins and internalized asialofetuin in primary cultured hepatocytes of rats

1989 • 12 citations