Ligand-stimulated β2-adrenergic receptor internalization via the constitutive endocytic pathway into rab5-containing endosomes

Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa

1987 • 11,491 citations

LIGAND: A versatile computerized approach for characterization of ligand-binding systems

1980 • 8,534 citations

[6] Use of T7 RNA polymerase to direct expression of cloned genes

1990 • 6,681 citations

The small GTPase rab5 functions as a regulatory factor in the early endocytic pathway

1992 • 1,342 citations

Localization of low molecular weight GTP binding proteins to exocytic and endocytic compartments

1990 • 1,150 citations

Signal transducing molecules and glycosyl-phosphatidylinositol-linked proteins form a caveolin-rich insoluble complex in MDCK cells

1993 • 961 citations

Hypertonic media inhibit receptor-mediated endocytosis by blocking clathrin-coated pit formation.

1989 • 920 citations

The small GTP-binding protein rab4 controls an early sorting event on the endocytic pathway

1992 • 648 citations

Caveolae: where incoming and outgoing messengers meet.

1993 • 616 citations

Sequestration of GPI-Anchored Proteins in Caveolae Triggered by Cross-Linking

1994 • 505 citations

Caveolae and sorting in the trans-Golgi network of epithelial cells.

1993 • 461 citations

Distinct endocytotic pathways in epidermal growth factor-stimulated human carcinoma A431 cells [published erratum appears in J Cell Biol 1990 Mar;110(3):859]

1989 • 448 citations

Ligand-regulated internalization and recycling of human beta 2-adrenergic receptors between the plasma membrane and endosomes containing transferrin receptors.

1992 • 445 citations

Molecular mechanisms of membrane receptor desensitization

1993 • 442 citations

A small GTP-binding protein dissociates from synaptic vesicles during exocytosis

1991 • 441 citations

Induction of caveolin during adipogenesis and association of GLUT4 with caveolin-rich vesicles.

1994 • 413 citations

Beta-adrenergic receptor sequestration. A potential mechanism of receptor resensitization.

1993 • 387 citations

The Human Rab Genes Encode a Family of GTP-binding Proteins Related to Yeast YPT1 and SEC4 Products Involved in Secretion

1989 • 387 citations

Generation of protein-reactive antibodies by short peptides is an event of high frequency: implications for the structural basis of immune recognition.

1983 • 378 citations

The coated pit and macropinocytic pathways serve distinct endosome populations

1994 • 374 citations

A highly conserved tyrosine residue in G protein-coupled receptors is required for agonist-mediated beta 2-adrenergic receptor sequestration.

1994 • 361 citations

Catecholamine-specific desensitization of adenylate cyclase. Evidence for a multistep process.

1980 • 342 citations

Targeting of membrane proteins to endosomes and lysosomes

1994 • 304 citations

CGP-12177. A hydrophilic beta-adrenergic receptor radioligand reveals high affinity binding of agonists to intact cells.

1983 • 289 citations

The role of tyrosine kinase activity in endocytosis, compartmentation, and down-regulation of the epidermal growth factor receptor

1991 • 288 citations

The small GTP-binding protein rab4 is associated with early endosomes.

1991 • 286 citations

Surface distribution and recycling of the low density lipoprotein receptor as visualized with antireceptor antibodies.

1982 • 240 citations

Stereospecific [3H](−)-alprenolol binding sites, β-adrenergic receptors and adenylate cyclase

1974 • 229 citations

Inhibition of receptor-mediated but not fluid-phase endocytosis in polymorphonuclear leukocytes.

1985 • 225 citations

Antagonist-dependent and -independent steps in the mechanism of adrenergic receptor internalization

1994 • 196 citations

Protein kinase C activators inhibit receptor-mediated potocytosis by preventing internalization of caveolae

1994 • 184 citations

Rapid endocytosis of the transferrin receptor in the absence of bound transferrin.

1985 • 167 citations

Internalization of beta-adrenergic receptor in A431 cells involves non-coated vesicles.

1989 • 155 citations

Insulin and okadaic acid induce Rab4 redistribution in adipocytes.

1993 • 154 citations

Genetic analysis of beta-adrenergic receptor internalization and down-regulation.

1985 • 102 citations

Potocytosis of small molecules and ions by caveolae

1993 • 87 citations

Selective regulation of apical endocytosis in polarized Madin-Darby canine kidney cells by mastoparan and cAMP

1994 • 75 citations

β 2-Adrenoceptor desensitization in cultured human airway smooth muscle

1993 • 54 citations

Biochemical and Functional Characterization of a Recombinant GTPase, Rab5, and Two of Its Mutants

1995 • 54 citations

Mechanism of Transferrin Receptor Down-regulation in K562 Cells in Response to Protein Kinase C Activation

1995 • 42 citations

Do agonists promote rapid internalization of beta-adrenergic receptors?

1985 • 39 citations

Agonist-Induced Desensitization of β-Adrenoceptors of Bovine Bronchial Epithelial Cells

1993 • 16 citations

Receptor-mediated endocytosis and lysosomal transport

1992 • 1 citations