The evolution and structural anatomy of the small molecule metabolic pathways in Escherichia coli

SCOP: A structural classification of proteins database for the investigation of sequences and structures

1995 • 6,372 citations

Chemical and biological evolution of a nucleotide-binding protein

1974 • 1,457 citations

Evolving Genes and Proteins

1965 • 1,314 citations

Hidden Markov models for detecting remote protein homologies.

1998 • 1,122 citations

ENZYME RECRUITMENT IN EVOLUTION OF NEW FUNCTION

1976 • 1,071 citations

Molecular archaeology of the Escherichia coli genome

1998 • 937 citations

SALIVARY CHROMOSOME MAPS

1935 • 682 citations

Evolution of function in protein superfamilies, from a structural perspective 1 1Edited by A. R. Fersht

2001 • 665 citations

On the Evolution of Biochemical Syntheses

1945 • 595 citations

Sequence comparisons using multiple sequences detect three times as many remote homologues as pairwise methods

1998 • 560 citations

Untitled

1995 • 545 citations

Assessing sequence comparison methods with reliable structurally identified distant evolutionary relationships

1998 • 532 citations

PSEUDOALLELISM AND GENE EVOLUTION

1951 • 358 citations

Structural Evidence for Evolution of the β/α Barrel Scaffold by Gene Duplication and Fusion

2000 • 301 citations

Understanding Enzyme Superfamilies

1997 • 280 citations

Comparative Genomics of the Archaea (Euryarchaeota): Evolution of Conserved Protein Families, the Stable Core, and the Variable Shell

1999 • 270 citations

Enzyme Nomenclature. Recommendations 1992

1994 • 247 citations

Pathway alignment: application to the comparative analysis of glycolytic enzymes

1999 • 240 citations

Homologies in serine proteinases

1970 • 239 citations

Homology among (βα) 8 barrels: implications for the evolution of metabolic pathways 1 1Edited by G. Von Heijne

2000 • 204 citations

Variation and evolution of the citric-acid cycle: a genomic perspective

1999 • 190 citations

Evolution of a metabolic pathway for degradation of a toxic xenobiotic: the patchwork approach

2000 • 184 citations

Structural conservation in parallel .beta./.alpha.-barrel enzymes that catalyze three sequential reactions in the pathway of tryptophan biosynthesis

1991 • 158 citations

Mandelate racemase and muconate lactonizing enzyme are mechanistically distinct and structurally homologous

1990 • 128 citations

On the origin of enzymatic species

1993 • 124 citations

Evolution of protein function, from a structural perspective

1999 • 116 citations

The Evolution of Biochemical Syntheses — Retrospect and Prospect

1965 • 97 citations

Eco Cyc: Encyclopedia of Escherichia coli genes and metabolism

1999 • 86 citations

Gene and context: Integrative approaches to genome analysis

2000 • 75 citations

Pathway alignment: application to the comparative analysis of glycolytic enzymes

1999 • 75 citations

Currents in Computational Molecular Biology

2000 • 65 citations

DIVCLUS: an automatic method in the GEANFAMMER package that finds homologous domains in single- and multi-domain proteins.

1998 • 56 citations

Can homologous proteins evolve different enzymatic activities?

1993 • 51 citations

Genes and proteins of Escherichia coli (GenProtEc)

1996 • 50 citations

Genes and proteins of Escherichia coli K-12

1998 • 48 citations

Divergence of Function in Sequence-Related Groups of Escherichia coli Proteins

2001 • 23 citations

Deleted Work

1955 • 0 citations