The systemic administration of Ig-4-1BB ligand in combination with IL-12 gene transfer eradicates hepatic colon carcinoma

Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors

1997 • 886 citations

Inducible T cell antigen 4-1BB. Analysis of expression and function.

1993 • 416 citations

NK1.1 Cells Express 4-1BB (CDw137) Costimulatory Molecule and Are Required for Tumor Immunity Elicited by Anti-4-1BB Monoclonal Antibodies

1998 • 361 citations

Current protocols in immunology

1992 • 356 citations

4-1BB Ligand Induces Cell Division, Sustains Survival, and Enhances Effector Function of CD4 and CD8 T Cells with Similar Efficacy

2001 • 352 citations

Role of 4-1BB in immune responses

1998 • 312 citations

Expression and function of 4-1BB and 4-1BB ligand on murine dendritic cells

2002 • 285 citations

Provision of antigen and CD137 signaling breaks immunological ignorance, promoting regression of poorly immunogenic tumors

2002 • 265 citations

Adenovirus-mediated interleukin-12 gene therapy for metastatic colon carcinoma.

1996 • 231 citations

Cutting Edge: Expression of Functional CD137 Receptor by Dendritic Cells

2002 • 231 citations

Provision of antigen and CD137 signaling breaks immunological ignorance, promoting regression of poorly immunogenic tumors

2002 • 215 citations

High-Affinity Interactions of Tumor Necrosis Factor Receptor-Associated Factors (TRAFs) and CD40 Require TRAF Trimerization and CD40 Multimerization

1999 • 154 citations

Immunomodulatory Gene Therapy With Interleukin 12 and 4-1BB Ligand: Long- Term Remission of Liver Metastases in a Mouse Model

2000 • 120 citations

Preparation of Cells and Reagents for Flow Cytometry

2001 • 108 citations

Incorporation of an Isoleucine Zipper Motif Enhances the Biological Activity of Soluble CD40L (CD154)

1999 • 99 citations

Divergent effects of 4-1BB antibodies on antitumor immunity and on tumor-reactive T-cell generation.

2001 • 92 citations

Rejection of Disseminated Metastases of Colon Carcinoma by Synergism of IL-12 Gene Therapy and 4-1BB Costimulation

2000 • 88 citations

4-1BB: Still in the Midst of Darkness

2000 • 68 citations

Thermodynamic characterization of the interaction between TRAF2 and tumor necrosis factor receptor peptides by isothermal titration calorimetry

2000 • 63 citations

Regulation of Dendritic Cell Function by NK Cells: Mechanisms Underlying the Synergism in the Combination Therapy of IL-12 and 4-1BB Activation

2004 • 55 citations

T cell activation with systemic agonistic antibody versus local 4-1BB ligand gene delivery combined with interleukin-12 eradicate liver metastases of breast cancer

2002 • 54 citations

Therapeutic Potential of 4-1BB (CD137) As a Regulator for Effector CD8⁺T Cells

2001 • 12 citations